The prevalence of cannabis-induced psychosis has increased substantially, possibly due to higher cannabis potency and greater use. Antipsychotic medication reduced hospitalization risk by 25% for psychosis, 25% for substance use disorders, and 50% for medical conditions. For psychosis-related hospitalization, long-acting injectable aripiprazole or olanzapine reduced risk by 75%—twice as...
Psychological MedicineAugust 26, 2025Lydia Johnson-Ferguson, Michelle Loher, Laura Bechtiger et al.2 citations
Cannabis use in young adulthood is common, yet few studies have explored how it predicts changes in psychopathology and functional well-being in community samples. We assessed these links using both self-reported frequency of cannabis use and hair THC concentrations. Data came from a community sample of young adults (N = 863) who reported cannabis use (weekly-to-daily use: n = 150) and provided...
Este artigo propõe uma investigação multidisciplinar, histórico-filosófica e etnobotânica sobre a constituição do Museu Brasileiro da Cannabis, abordando seus pressupostos políticos, epistemológicos e ancestrais. A partir de um diálogo entre estudos canábicos, epistemologias do Sul, mitologia comparada, filosofia da ciência e crítica cultural, o trabalho reconstrói genealogias esquecidas da...
Cannabis is a widely used illicit substance that is historically consumed via smoking, but alternative methods of cannabis consumption have been growing in popularity over the past several decades. One such modality is vaporization, which can appeal specifically to adolescent consumers given these pen devices’ ease of concealment, lack of characteristic odor, and marketability. Cannabis...
Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure. Data were derived from...
Cannabis-induced psychosis (CIP) represents a significant public health concern in the context of increasing global cannabis use and potency. This review synthesizes current evidence on the epidemiology, neurobiological mechanisms, clinical features, and treatment approaches for cannabis-induced psychotic disorders. Recent epidemiological data indicate rising incidence rates of CIP, with...
Revista de Ciencias SocialesAugust 5, 2025Viriam Leiva Díaz, Beatriz Villalobos Núñez, Mariela Francine Rodríguez Valerio et al.
Chronic marijuana use has been linked to negative effects on executive functions, but there is uncertainty with recreational, sporadic, and non-dependent use. This article reports and analyzes the results of a systematic review of the evidence that has evaluated this issue specifically in young people. Only two studies that met the inclusion criteria were identified in the OVID, Embase and...
Social factors significantly influence the initiation and progression of cannabis use and cannabis use disorder. Although cannabis is the most widely used drug globally, its social cognitive aspects and neural correlates have rarely been studied. To evaluate the findings to date and to guide future research, this systematic review assesses neuroimaging evidence on the associations between...
Cue-induced craving-the desire to use a drug triggered by exposure to cues associated with prior use-is a central mechanism in the development and maintenance of problematic substance use behaviours. Drug cues have the power to induce craving even in long-term abstinent individuals, which has led clinicians to advise patients to avoid the people, places and objects that are associated with...
Δ9-tetrahydrocannabinol (THC) is responsible for the intoxicating (psychotropic) effects of cannabis and cannabis-derived products currently available in the legal and illegal markets. The psychotropic effects of THC are produced via activation of CB1 cannabinoid receptors in the brain, which are normally engaged by endogenous cannabinoid (endocannabinoid) substances. Outside the brain, THC...
Heavy and daily use of cannabis with high contents of Δ9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with THC during adolescence and found that this exposure impaired social interaction and increased vulnerability to develop sensorimotor gating deficiencies comparable to those...
Cannabis use represents a significant risk factor for both psychotic disorders and suicidal behaviors, with growing evidence suggesting complex interactions between these variables. This systematic review examines the relationship between cannabis use and suicide risk in first-episode psychosis (FEP) patients, and explores underlying mechanisms, moderating factors, and intervention strategies....
The convergence of early initiation, increasing product potency, and widespread availability has reshaped the contemporary cannabis landscape, heightening concerns about its impact on adolescent mental health. Translational research combining longitudinal human neuroimaging and animal models provides compelling evidence that cannabis use-particularly with high-tetrahydrocannabinol (THC)...
Neurology InternationalJuly 1, 2025Andréia Pucinelli de Souza Queiroz, M. O. Pozzolo Pedro, Marcela Waisman Campos et al.
Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several domains of cognition, yet findings across studies remain varied and fragmented. This comprehensive review synthesizes current knowledge on the long-term cognitive consequences of...
Introduction Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on...
Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)-triggered neuroadaptive changes in the maturing amygdala remain unclear. Proteomic analysis of amygdala tissue from male adolescent Saimiri boliviensis nonhuman primates chronically treated with THC provided leads...
Este artículo desarrolla una discusión epistemológica sobre la ambigüedad conceptual que caracteriza la clasificación científica de sustancias como el cannabis, el tabaco y la coca. El objetivo es analizar la porosidad epistémica que emerge cuando estas sustancias son abordadas exclusivamente desde perspectivas etnofarmacológicas, farmacológicas y psicológicas, en ausencia de comprensiones...
Psychoactive substances are compounds that can influence perception, consciousness, cognition, and emotions. The psychoactive substances caffeine, nicotine, cannabis, and psilocybin all originate from natural sources and can be used without complex processing or synthesis. Their natural availability has contributed to a long-standing history of human use and cultural significance. Caffeine and...
There are few effective pharmacotherapies for treating eating disorders (EDs). High rates of substance use among individuals with EDs suggest potential self-medication of symptoms. To explore the experiences of individuals with EDs regarding use of prescribed and nonprescribed drugs. This survey study assessed responses to the Medications and Other Drugs for Eating Disorders (MED-FED) survey,...
Correlation between Cannabis sativa use and the development of psychotic disorders, including schizophrenia, has been documented in several studies. Currently, this relationship is understood within a multifactorial model, where genetic, neurobiological, and environmental determinants interact. This review aims to analyze the influence of early Cannabis sativa use on the development of...