Clinical EEG and Neuroscience
November 25, 2022
Shariful A. Syed, Ashley M. Schnakenberg Martin, Jose A Cortes-Briones et al.
Disruptions in neural oscillations are believed to be one critical mechanism by which cannabinoids, such as delta-9-tetrahyrdrocannabinol (THC; the primary psychoactive constituent of cannabis), perturbs brain function. Here we briefly review the role of synchronized neural activity, particularly in the gamma (30–80 Hz) and theta (4–7 Hz) frequency range, in sensation, perception, and...
Journal of Psychopharmacology
May 25, 2021
Ashley M. Schnakenberg Martin, Dae-Jin Kim, Sharlene D. Newman et al.
Background: Cannabis use has been associated with abnormalities in cerebellar mediated motor and non-motor (i.e. cognition and personality) phenomena. Since the cerebellum is a region with high cannabinoid type 1 receptor density, these impairments may reflect alterations of signaling between the cerebellum and other brain regions. Aims: We hypothesized that cerebellar-cortical resting-state...
Journal of Mental Health
January 2, 2020
Ashley M. Schnakenberg Martin, Paul H Lysaker
Abstract Background: While previous research suggests that active cannabis use is a barrier to the emotional experiences of anticipating pleasure and expressing emotion in early psychosis, the relationship between lifetime cannabis use, emotional experience and social function over time has been understudied. Aims: This study sought to characterize the influence of lifetime cannabis use on...
Human Brain Mapping
January 2019
Dae-Jin Kim, Ashley M. Schnakenberg Martin, Yong-Wook Shin et al.
Cellular studies indicate that endocannabinoid type-1 retrograde signaling plays a major role in synaptic plasticity. Disruption of these processes by delta-9-tetrahydrocannabinol (THC) could produce alterations either in structural and functional brain connectivity or in their association in cannabis (CB) users. Graph theoretic structural and functional networks were generated with diffusion...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
October 3, 2017
Mohini Ranganathan, Rajiv Radhakrishnan, Peter H. Addy et al.
Cannabis and agonists of the brain cannabinoid receptor (CB1R) produce acute memory impairments in humans. However, the extent to which cannabinoids impair the component processes of encoding and retrieval has not been established in humans. The objective of this analysis was to determine whether the administration of Δ9-Tetrahydrocannabinol (THC), the principal psychoactive constituent of...
Schizophrenia Research: Cognition
December 1, 2016
Ashley M. Schnakenberg Martin, K. Bonfils, Beshaun J. Davis et al.
Literature on the relationship of cannabis use and cognition in schizophrenia provides the paradoxical view that cannabis use is sometimes linked with less severe impairment in neurocognition. This paper explored the possibility that this is a reflection of a dose related response between lifetime cannabis use and two forms of cognition, neurocognition and metacognition, in schizophrenia. It...