Clinical Toxicology
April 1, 2024
Rachael Wilkes, Darren M Roberts, Paul Liknaitzky et al.
8 citations
The global use of certain classical psychedelics has increased in recent years, but little is known about their spectrum of toxicity within Australia. We aim to describe calls to New South Wales Poisons Information Centre relating to exposures to classical psychedelics including lysergic acid diethylamide, psilocybin, N,N-dimethyltryptamine, ayahuasca, mescaline and ibogaine. This is a...
Qeios
January 17, 2024
Ana María Rosso
1 citation
The purpose of this article is to study the 'sacred' plants, diverse from those exclusively medicinal but with an unquestionable ethnobotanical value because, added to their healing properties, they develop mystical experiences and altered states of consciousness analogous to the ecstatic trance. _Psychoactive_ plants have played an important role in medicine, religion, _ritual_ life, and...
Journal of Psychoactive Drugs
2024
Kelan Thomas, Robert L. Jesse, Nicky J. Mehtani et al.
4 citations
In recent years, policymakers have proposed and implemented regulatory changes promoting the deprioritization, decriminalization, or state-level legalization of one or more psychedelic substances, usually referencing data from clinical trials as reasons to support liberalizing drug control policies. As psychedelic policies continue to be drafted, personal possession limits may be considered for...
Journal of Psychopharmacology
2024
Lisa Luan, Emma Eckernäs, Michael Ashton et al.
41 citations
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces a rapid and transient altered state of consciousness when inhaled or injected via bolus administration. Its marked and novel subjective effects make DMT a powerful tool for the neuroscientific study of consciousness and preliminary results show its potential role in treating mental health conditions. In a within-subjects,...
Advances in experimental medicine and biology
2024
Berend Olivier, Jocelien D A Olivier
11 citations
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, associated with substantial burden and large economical costs. Notwithstanding various conventional antidepressant treatment options, a large portion of depressed people (ca. 30%) fails to respond to first-line treatment, resulting in treatment-resistant depression (TRD). Although non-response to multiple antidepressant...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
December 31, 2023
Francisco Madrid-Gambin, David Fabregat-Safont, Alex Gomez-Gomez et al.
12 citations
Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is...
Ciencias Sociales y Religión
December 19, 2023
Karla Ivonne Moreno Constantino, Olga Olivas
1 citation
En este artículo se analizan las experiencias corporizadas de sanación, espiritualidad y bienestar catalizadas por el consumo ritual de ayahuasca por parte de mujeres en la ciudad de Tijuana. La reterritorialización de la práctica ritual de ayahuasca da cuenta de su inserción en los circuitos de terapias alternativas que se organizan en la ciudad, y en los ensamblajes terapéutico-espirituales...
Ciencias Sociales y Religión
December 19, 2023
Henrique Fernandes Antunes
1 citation
O presente artigo analisa a proibição do uso da ayahuasca na França. Para isso, nos valemos de um amplo acervo documental que abrange a literatura acadêmica, documentos de órgãos governamentais, decisões judiciais, tratados internacionais, relatórios farmacológicos e entrevistas com atores-chave envolvidos no processo. Inicialmente, descrevemos a inserção da ayahuasca na França e a prisão do...
Research, Society and Development
December 13, 2023
Caíque Gois Cardoso, Milena de Barros Viana
2 citations
Introduction: With the progressive advancement of clinical and experimental trials aimed at investigating the pharmacotherapeutic potential of psychedelic substances, there is also the development of other conceptions of use, not only for the treatment of psychiatric disorders, but also for the improvement of emotional/cognitive functions. Objective: The present study is a systematic review of...
Molecules
December 5, 2023
Marjolein Doesburg-Van Kleffens, Amy Marisa Zimmermann-Klemd, Carsten Gründemann
13 citations
Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mescaline. Here, mescaline induces the psychoactive effects of peyote through the activation of the serotonin 5-HT2A receptor and the subsequent release of calcium (Ca2+) from the endoplasmic reticulum (ER). Moreover, an evaluation of the therapeutic...