Current Topics in Behavioral Neurosciences
November 22, 2025
Maha N. Mian, Allison R. Coker, Grace Kretzer et al.
Alongside the important contributions of the harm reduction movement to improving public health in secular settings, communities that use psychedelics as religious sacraments (i.e., entheogens) have developed their own frameworks for supporting safety within their spiritual practices and hold their own conceptualizations of risk and harm. In order to understand better the lived realities of...
Journal of Psychedelic Studies
November 20, 2025
Oscar Véliz-García, Marcos Domic-Siede
Abstract This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding naturalistic use outside clinical settings. A total of 4,810 participants from six Latin American countries completed an online survey assessing sociodemographic characteristics, substances used, consumption contexts, motivations, and subjective...
Brain Disorders
September 23, 2025
Matthew Halma, R. Levy, Joseph Varón
2 citations
Clinicians and researchers are showing increased interest in psychedelic-assisted therapy for patients who don't show improvement from using conventional antidepressants. This updated review integrates recent developments, including data on lesser-studied compounds like DMT and 5-MeO-DMT, findings from large clinical trials, and evolving regulatory landscapes. In treatment-resistant depression,...
Journal of Eating Disorders
September 2, 2025
Elena Koning, Riccardo Miceli Mcmillan, Aaron Keshen et al.
3 citations
Psychedelic-assisted therapy (PAT) is an emerging intervention in psychiatry, for which there is preliminary evidence for effectiveness in eating disorders (EDs). The subjective psychedelic experience is considered an important driver of positive outcomes following PAT; however, conventional study design approaches often overlook many of the nuances inherent to the experience. Consequently,...
INTERdisciplina
August 30, 2025
Genlizzie Elizabeth Garibay Munguía
This article aims to understand how contemporary psychedelic capitalism, through medicalization, regulation, and commodification of ancestral psychoactive substances (such as psilocybin mushrooms, peyote, ayahuasca and others), reproduces dynamics of biopiracy and bioappropriation that exploit the territories, knowledge, and practices of indigenous communities. From a critical perspective...
Brain and Behavior
July 1, 2025
Megan Calnan, Grace Blest‐hopley, Chris Busch et al.
4 citations
Abstract Background : Military veterans are at risk of various mental health conditions, with profound implications for post‐deployment quality of life. Current treatment options encounter high dropout rates and non‐responsiveness, and overlook the importance of community building in veterans’ holistic recovery. Preliminary research suggests psychedelics offer therapeutic benefits for...
Psychiatry Research
June 1, 2025
Jeremy Weleff, Alejandra Pulido-Saavedra, Ardavan Mohammad Aghaei et al.
4 citations
Opioid-related overdose deaths have reached record high levels, and novel treatments for opioid use disorder (OUD) are needed. The three United States Food and Drug Administration (FDA)-approved medications for OUD function primarily at the mu-opioid receptor. While these remain the gold-standard treatment for OUD, they have shortcomings and treatment options separate from the opioid receptor...
Journal of Psychoactive Drugs
May 29, 2025
Araam Abboud, Kyle Hua, Hannah Redding et al.
1 citation
This study examined patient perspectives on psilocybin therapy, specifically their acceptance and views on the therapeutic benefits of both hallucinogenic and non-hallucinogenic forms. A cross-sectional survey was conducted among psychiatric patients aged 18-65 at a community mental health center, assessing their attitudes, knowledge, and acceptance of psilocybin therapy. In total, 62.4% of the...
Journal of Psychopharmacology
May 12, 2025
Clémentine Estric, Thomas Duron, Sarah Kabani et al.
10 citations
Psychedelics offer promising outcomes in psychiatry. However, the preparation of participants (set) and the environmental conditions of taking a psychedelic (setting) are not standardized. We describe the set and setting for therapeutic use of psychedelic drugs in people with psychiatric disorders. In this systematic review, articles were identified in the PubMed and Web of Science databases...
Journal of Psychoactive Drugs
March 31, 2025
Samuel Thomson, Nikos Thomacos
11 citations
Psychedelic-assisted therapy is gaining recognition for its potential to enhance human functioning. While most research has focused on psychedelic' therapeutic use for mental illness, this review applies the PERMA Theory of Well-Being to systematically examine their role in enhancing well-being in healthy individuals. The final search of five academic databases was conducted on February 4,...