Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
March 1, 2025
Klemens Egger, Javier Jareño Redondo, Jovin Müller et al.
14 citations
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors. However, the pharmacological interactions between these compounds remain incompletely understood. In this study, we developed an ayahuasca-inspired formulation containing DMT and harmine, aiming to...
Ankara Universitesi Eczacilik Fakultesi Dergisi
January 13, 2025
Merve Akdoğan, Enes Tekman, Hafize Yuca et al.
1 citation
Objective: Peganum harmala L., commonly known as "harmala," is extensively used as an herbal incense product today and is renowned for its reported calming effects on humans. This study aims to perform a structural characterization of incense, with a particular focus on its fruit and seed components, by analyzing both the combustion process and dissolving the resulting smoke in an appropriate...
2025
Tatiana Tiaynen-Qadir
West in the 1950s shared the view that psychedelic experiences culminate in “mystical experiences” of union. However, the recent “psychedelic renaissance” emphasizes biomedical, neurological, and psychotherapeutic explanations. These clinical, instrumental approaches overlook both new research on mysticism and many cultural realities and practices behind it. Analyzing key research on...
Current Addiction Reports
2025
Anahita Bassir Nia, Yalda Farahmand, Garret Griffith et al.
Despite national efforts to curb the opioid crisis, the clinical and societal challenges continue to grow. FDA-approved medications for opioid use disorder (OUD) are effective but are associated with high rates of treatment discontinuation and relapse. A collection of agents with acute effects on consciousness, collectively (if variably) categorized as 'psychedelics', have emerged as potential...
International review of neurobiology
2025
Caitlin M. DuPont, Matthew W. Johnson
6 citations
The current chapter presents the literature evaluating the effects of classic psychedelic treatments on five substance use disorders: alcohol, tobacco, opioid, stimulant, and cannabis. Most work on psychedelics and substance use disorders was conducted for alcohol use disorder. A range of classic psychedelics (LSD, psilocybin, and ayahuasca) appear to be beneficial for facilitating both reduced...
Health Education & Behavior
December 1, 2024
Ilana Berlowitz, Ernesto García Torres, Juan Celidonio Ruiz Macedo et al.
3 citations
Although the tobacco plant has been employed as a medicinal and sacred herb by Indigenous cultures across the Americas, its usage drastically changed after the 15th-century colonial arrival; its large-scale commodification and global marketing once brought to Europe lead to hedonic and addictive uses harmful to health. As a consequence, tobacco smoking is now one of the largest public health...
British Journal of Clinical Pharmacology
December 1, 2024
Gisela Lima, Carla Soares, Marta Teixeira et al.
4 citations
Recent years have witnessed an unprecedented increase in the search for the use of psychedelics in improving physical and mental health. Anaesthesia has evolved since very early times, born from the need to eliminate pain and reduce suffering and there are reports of the use of anaesthetics to achieve mystical states since the nineteenth century. Nowadays, the renaissance of psychedelics in...
Psychoactives
November 8, 2024
Jonathan Tran, Aaron Elkins, Simone Vassiliadis et al.
1 citation
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior. A subclass of psychoactive drugs, psychedelics, are hallucinogenic drugs that can trigger psychedelic experiences and possible changes in mental perception. The potential use of psychedelics as a therapeutic has led to an increase in clinical...
Pharmaceuticals
November 5, 2024
Tamara Valdez, Valbhi Patel, Nattaphone Senesombath et al.
4 citations
Psychedelics have recently (re)emerged as therapeutics of high potential for multiple mental health conditions, including substance use disorders (SUDs). Despite early mid-20th century anecdotal reports and pilot studies demonstrating the possibility of these substances in efficaciously treating conditions such as alcohol and opioid use disorders, legal restrictions and social stigma have...
Journal of Psychoactive Drugs
October 15, 2024
Jamie E Parnes, Mitch Earleywine
Despite increasing interest in psychedelics and their potential therapeutic effects, research on inhaled N,N-Dimethyltryptamine (DMT) remains limited. Inhaled DMT has a reputation for rapid, dramatic onset and a brief duration, but correlates of use frequency remain poorly understood. A sample recruited from relevant internet sites, including nearly 400 people who had inhaled DMT, reported...