February 27, 2023
Henrique Fernandes Antunes
2 citations
The purpose of this chapter is to analyze the legal dispute between the US government and a Santo Daime church—the Church of the Holy Light of the Queen (CHLQ), located in Ashland, Oregon—that culminated in the regulation process of ayahuasca in that state. Initially, I will briefly describe the insertion of the Santo Daime into the United States, the beginning of tensions with the governmental...
Psychiatric News
February 16, 2023
Terri D'Arrigo
Bills that would decriminalize the use of psychedelics are popping up faster than magic mushrooms, but the field of psychedelics research has yet to yield supporting evidence about their safety and efficacy. Legislative reform regarding psychedelics is gaining ground, a study in JAMA Psychiatry has found. From January 1, 2019, to September 28, 2022, 25 states considered 74 bills that proposed...
Frontiers in Psychiatry
February 10, 2023
Muhammad Ishrat Husain, Nicole Ledwos, Elise Fellows et al.
47 citations
Introduction Current treatment options for major depressive disorder (MDD) have limited efficacy and are associated with adverse effects. Recent studies investigating the antidepressant effect of serotonergic psychedelics—also known as classic psychedelics—have promising preliminary results with large effect sizes. In this context, we conducted a review of the putative neurobiological...
Journal of Affective Disorders
February 1, 2023
Kwonmok Ko, Emma I Kopra, Anthony J. Cleare et al.
144 citations
Psychedelic therapy shows promise for Major Depressive Disorder, especially when treatment-resistant, as well as life-threatening illness distress. The objective of this systematic review, inclusive of meta-analysis, is to examine recent clinical research on the therapeutic effects of classic psychedelics on depressive symptoms. Fourteen psychedelic therapy studies, utilising psilocybin,...
Plants
January 11, 2023
Ilana Berlowitz, Ernesto García Torres, Caroline Maake et al.
14 citations
Harmful usage of tobacco is a global public health problem associated with adverse health effects and addiction. Yet, in the Peruvian Amazon, the native region of Nicotiana rustica L., this plant is used in remarkably different manners: it is considered a potent medicinal plant, applied in liquid form for oral ingestion to treat mental health problems, a common and ancient healing practice in...
Journal of Psychoactive Drugs
2023
Aviad Hadar, Jonathan David, Nadav Shalit et al.
93 citations
Psychedelics were used in the treatment of psychiatric conditions prior to their prohibition in the late 1960s. In the past three decades, there is a revived research interest in the therapeutic potential of psychedelic drugs with expected FDA approvals for treatment of various conditions. Given the exponential scientific growth of this field, we sought to characterize, analyze, and visualize...
Frontiers in Pharmacology
2023
Klemens Egger, Frederik Gudmundsen, Naja Støckel Jessen et al.
17 citations
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism of oral DMT, ayahuasca preparations additionally contain reversible monoamine oxidase A (MAO-A) inhibitors, namely β-carboline alkaloids such as harmine....
Neuropharmacology
December 21, 2022
Mason Marks
59 citations
After decades of prohibition, psychedelics are generating intense public and private interest. Scientists are researching the therapeutic properties of these substances, and mounting evidence supports their ability to treat a variety of mental health conditions. Meanwhile, dozens of cities and states are proposing or enacting psychedelics legislation to promote research, increase therapeutic...
Anthropology & medicine
December 1, 2022
Manuela R Müller, Francisco Ortega, Angel Martínez-Hernáez
13 citations
Brazilian mental health care reform understands mental health as a complex social process. There is a large literature production within the country focused on deinstitutionalization policy, social determinants of mental health and human rights, however, with little recognition beyond Latin American borders. In addition, cultural dimensions of mental suffering have been neglected in Brazilian...
Psychoactives
November 21, 2022
Rafael G. Dos Santos, Jaime E. C. Hallak
In the last two decades, an increasing trend has unfolded toward the possible beneficial uses of natural hallucinogenic substances for treating mental health disorders [...]