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Ayahuasca may help to improve self‐compassion and self‐criticism capacities

Elisabet Domínguez‐clavé, Joaquim Soler, Matilde Elices, Alba Franquesa, Enric Álvarez, Juan Carlos Pascual

Human Psychopharmacology: Clinical and Experimental August 19, 2021 DOI: 10.1002/hup.2807 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Pre-post observational study Peer reviewed
Sample size 45
Population Community sample of volunteers attending an ayahuasca ceremony
Intervention Ayahuasca
Duration ≤24 hours post-ceremony
Topics Ayahuasca Meditation
Keywords Self-compassion Psychopathology Clinical psychology Self-criticism Psychotherapist Affect linguistics
Citations 30
Key findings Ayahuasca significantly improved self-compassion and self-reassurance and reduced self-criticism, with medium to large effect sizes, in a community sample.

Abstract

Abstract Objective Ayahuasca is a psychedelic brew that originated in the Amazon basin. The psychological effects of this drug are becoming better understood due to the growing research interest in identifying new potential therapeutic agents for the treatment of emotion dysregulation and other disorders. Previous studies suggest that ayahuasca enhances mindfulness‐related capacities (decentering, non‐judging, non‐reacting and acceptance) and emotion regulation. The aim of the present exploratory study was to determine the effects of ayahuasca on self‐compassion in a community sample.

Methods: We administered validated questionnaires (the Self‐Compassion Scale‐Short Form and Forms of Self‐Criticism and Self‐Reassurance) to evaluate pre‐post changes in self‐compassion and self‐criticism/self‐reassurance in 45 volunteers (27 women; 60%) before and after (≤24 h) an ayahuasca ceremony. Most participants ( n = 29; 67.4%) had previously used ayahuasca.

Results: Ayahuasca resulted in significant improvements, with medium to large effect sizes ( η 2 = 0.184–0.276), in measures of self‐compassion ( p < 0.05), self‐criticism ( p < 0.01) and self‐reassurance ( p < 0.01).

Conclusions: The findings of this study suggest that ayahuasca promotes well‐being and self‐compassion, which could have a therapeutic effect on individuals with negative affect and other psychopathological conditions. Large, controlled studies are needed to confirm these findings.

Comparable studies

Other non-randomized and open-label trials on ayahuasca, most cited first.

Study Year Design Participants
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression Patients with recurrent depression 2015 Open-label trial n = 17
Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities Healthy volunteers 2017 Open-label uncontrolled study n = 16
Rapid and sustained decreases in suicidality following a single dose of ayahuasca among individuals with recurrent major depressive disorder: results from an open-label trial. Individuals with recurrent major depressive disorder 2021 Open-label trial (secondary analysis) n = 17
Pilot Evaluation of a Residential Drug Addiction Treatment Combining Traditional Amazonian Medicine, Ayahuasca and Psychotherapy on Depression and Anxiety Male patients in an inpatient addiction treatment program 2020 Pre-post observational study n = 31
Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up Patients with treatment-resistant major depressive disorder who had participated in an... 2018 Long-term follow-up of an open-label trial n = 8

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