Anxiety and stress-related disorders affect over 280 million individuals worldwide and remain inadequately treated by current pharmacotherapies, which are often limited in efficacy and tolerability. Ketamine produces rapid therapeutic effects in mood and anxiety disorders, but its clinical use is constrained by dissociative side effects and abuse liability. Ketamine metabolites, particularly (2...
Research SquareJuly 8, 2026Hacer Unver Koca, Fadi̇me Bi̇çer Şahi̇n, Zeynep Unver et al.
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Abstract Purpose This study was conducted to determine the effect of mindfulness-based stress reduction (MBSR) training given to young girls experiencing fear of childbirth on their fear of childbirth, coping strategies with stress, and state anxiety levels. Methods The research was completed with 116 students (58 experimental, 58 control group) who experienced fear of childbirth. Data were...
BACKGROUND Patients undergoing peritoneal dialysis (PD) frequently experience anxiety and sleep disturbances.However, the comparative efficacy of psychological interventions on these symptoms remains unclear.AIM To compare the efficacy of mindfulness-based cognitive therapy (MBCT) and routine psychological support (PS) on anxiety symptoms and sleep quality in patients undergoing PD.METHODS This...
Pregnancy and childbirth represent a major transition into motherhood, marked by psychosocial changes that may increase women's vulnerability to mental health difficulties such as prenatal depression, anxiety, or PTSD, in addition to physical pain. These difficulties can negatively impact maternal well-being, the mother-infant relationship, and child development. Prenatal mindfulness-based...
BACKGROUND: -dimethyltryptamine (DMT); however, long-term effects, including broader well-being dimensions, are sparsely explored across populations. AIMS: Investigating whether DMT produces sustained improvements in anxiety, life satisfaction, and quality of life, in both healthy individuals and patients with treatment-resistant depression (TRD). METHODS: In 2 open-label clinical trials, 27...
This exploratory single-group pilot study examined whether a brief mindfulness-meditation routine was associated with lower Foreign Language Anxiety (FLA) and improved language-learning experience among Indonesian ESL learners in Singapore. Through a mixed-methods action research design, the study conducted twelve face-to-face mindfulness sessions across four weeks with young learners who...
In this paper, we propose a trans-materialist information-theoretical approach to a full spectrum of conscious experience, from its normative embodied mode as part of an integrated brain/mind system to altered modes of consciousness, including nonlocal and near-death experiences (NDE). It allows for bridging the Cartesian gap and resolving the “hard problem” of non-material mind arising from...
Background: This study compared the effects of mindfulness training (MT) and cognitive-behavioral training (CBT) on ADHD symptoms, test anxiety, and self-concept in children with ADHD and explored potential pathways of change associated with the two interventions. Methods: After a two-stage screening and eligibility confirmation procedure, 63 children with ADHD were included in the final...
DedicaJuly 6, 2026Saul de Melo Ibiapina Neres, Daisy Inocência Margarida de Lemos, Eleonardo Pereira Rodrigues et al.
A adolescência é um período crítico de desenvolvimento caracterizado por mudanças emocionais intensas, sendo a ansiedade um dos transtornos mais prevalentes nesse ciclo. O presente estudo teve como objetivo analisar a influência de práticas de Mindfulness na redução dos níveis de ansiedade em adolescentes do ensino médio de uma escola pública no interior do Piauí. Participaram 47 estudantes,...
BACKGROUND: Neurotic disorders - major depressive disorder (MDD), panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and specific phobia - have differing pharmaceutical profiles. But all, even when resistant to conventional treatment (TR), respond quickly to low dose (0.5-1.0 mg/kg I.M.) ketamine....
Self-referential processing (SRP), the mental activity of linking experiences and stimuli to the self, is fundamental to shaping identity, regulating affect, and navigating complex social environments. Disruptions in SRP are increasingly recognized as a transdiagnostic hallmark across psychiatric disorders, including schizophrenia spectrum disorders, major depressive disorder, and anxiety...
Anxiety is one of the most prevalent mental health problems in adolescence, and its onset often coincides with the secondary school years. Mindfulness-based interventions (MBIs) have shown short-term benefits for reducing anxiety in young people, but the durability of these benefits after treatment remains uncertain. To inform clinical and school-based practice, a quantitative synthesis focused...
El presente artículo realiza una revisión narrativa de la literatura científica sobre la relación entre mindfulness, bienestar psicológico y desempeño académico en estudiantes de Medicina. Se efectuó una búsqueda en las bases de datos Scopus, APA PsycNET y Web of Science (WoS), abarcando el período 2011–2024, intervalo definido por la consolidación de la investigación empírica sobre mindfulness...
High Resolution Image Download MS PowerPoint Slide Provided herein are novel 6,5-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse, and headaches, and processes for preparing such compounds.
Annals of medicineJuly 3, 2026Zheping Chen, Yaozhu Wang, Peilin Cong et al.
Patients undergoing acoustic neuroma (AN) surgery often experience postoperative negative emotions, including anxiety, depression, and immune function suppression. This trial evaluated whether perioperative sub-anesthetic esketamine improves early postoperative negative emotions and immune function. In this single-center, double-blind, randomized trial, 84 patients scheduled for AN surgery were...
Journal of Psychoactive DrugsJuly 3, 2026Miguel Joaquim Soares Teles Couceiro, Victor José da Conceição Teixeira Amorim Rodrigues, Nuno Manuel Correia Torres
This case study explores the potential role of mystical-type experiences in ketamine-assisted psychotherapy (KAP). A patient with generalized anxiety disorder and migraines underwent four intramuscular KAP sessions (0.5-0.9 mg/kg). Outcomes were assessed using the Outcome Questionnaire-45 (OQ-45), the Hood Mysticism Scale (HMS), and interviews. Greater therapeutic gains followed sessions with...
The fear of death (death anxiety) is a risk factor for various mental health conditions. Death anxiety has been theorized to elicit physiological arousal and worry and is empirically associated with attachment insecurity, each of which has been linked to disrupted sleep. However, limited research has explored the relationship between death anxiety, nightmares and insomnia. We examined the...
Introduction: Meditation has shown benefits for mental health, yet difficulties may appear when practicing autonomously, particularly in people prone to anxiety or low self-esteem. The POEBRA (Program for Optimizing Self-Esteem and Benevolence and Reducing Anxiety) was developed to facilitate meditation learning through a structured, embodied, guided approach based on Full-Presence meditation....
There is growing interest in psychedelic compounds such as psilocybin, 3,4-metheylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) given emerging research on potential uses as treatments for a variety of health conditions. The United States Food and Drug Administration (FDA) has granted multiple “Breakthrough Therapy” designations to various...
Depersonalization/derealization (dpdr) is known to occur across mood and anxiety disorders (MAD) and has been proposed as a marker of worse illness. However, despite the well-known clinical association, there are no epidemiological data on the relationship between dpdr and MAD. In this NCS-R analysis clinically significant dpdr (DPDR-C) was defined as "sometimes" or "often" past-month...