This research proposes to evaluate Transcendental Meditation (TM) as a complementary integrative practice in the treatment of Anxiety Disorders. Based on WHO data and the Brazilian context, the study highlights the high prevalence of anxiety and the need for therapeutic alternatives beyond the biomedical model. The research, conducted with adults diagnosed in the state of São Paulo, used online...
Objectives: Chronic musculoskeletal pain (CMP) is the leading cause of years lived with disability worldwide and the costliest health condition in the United States. Mindfulness is an effective treatment for CMP, but traditional mindfulness-based interventions (MBIs) are inaccessible for many CMP patients for both format and content reasons. An MBI that leverages music may be a more accessible...
Pharmacological ResearchNovember 22, 2025Zhuo-Ning Zhang, Xin-Yu Hao, Chen Cai et al.5 citations
This randomized, double-blind, parallel-group trial evaluated the efficacy of a single intravenous dose of esketamine (0.3mg/kg) administered at anesthesia induction in reducing postoperative depression and anxiety among patients undergoing cardiac valve surgery. A total of 142 patients from three centers were randomly assigned to receive esketamine or saline. The primary outcomes were the...
Scientia PsychiatricaNovember 19, 2025Ni Wayan Saka Rahayu, Putu Risdianto Eka Putra
Introduction: The pervasive integration of digital media into pediatric life has shifted the clinical focus from screen time quantity to content quality. Emerging "metaphysical" sub-genres, such as algorithmic "Lucid Dreaming" tutorials, pose unique risks to preadolescents. This case report aims to document a novel presentation of acute sleep anxiety precipitated specifically by "Lucid...
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic connections observed in depression. PET imaging using 11C-UCB-J, a radiotracer targeting the synaptic vesicle protein 2 A (SV2A), was investigated as a translational method to monitor ketamine-induced changes in synaptic density in the corticosterone...
Abstract First-hand experience with psychedelics may help clinicians develop skills and knowledge needed to work with the profound changes to conscious awareness occasioned by psychedelics. However, the topic remains contentious and underexplored. In this world-first study, we investigated the utility of psilocybin experiential therapist training in a sample of 14 mental healthcare...
Background: Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting roughly 322 million people. Recently, doses of psilocybin have shown promise in treating mood disorders, sparking interest in other dosing practices. According to anecdotal reports and observational studies, microdosing psilocybin yields benefits to mental health; however, rigorously controlled...
Correction: Correction: Effectiveness and satisfaction of mindfulness-based cognitive therapy for children on anxiety, depression, and internet addiction in adolescents: Study protocol for a randomized control trial.
Background: Buspirone shows a certain efficacy in patients with generalized anxiety disorder (GAD), but its combination therapy with mindfulness-based cognitive therapy (MBCT) remains unclear. To compare buspirone + MBCT versus buspirone alone for GAD in a retrospective cohort. Methods: According to the treatment regimens, patients were assigned to the experimental group (n = 50) to receive 120...
Horizonte SanitarioNovember 11, 2025J. Gonzáles, Javier González-Ramírez, Rosario Edith Ortiz-Félix et al.
Objective: To explore the feasibility of the intervention “Mindfulness to Reduce Anxiety in Women with Breast Cancer.” Materials and methods: A pilot study with a quasi-experimental design (pre- and post-test) was conducted. The sample consisted of women aged 30 to 69 years diagnosed with breast cancer who could read and write, had an electronic device with internet access, and had mild or...
Research SquareNovember 11, 2025Xuming Zhu, Xiaoyong Wei, Qianyu Guo et al.
preprint
Abstract Background: The incidence of preoperative anxiety in children is significantly higher than in adults. Esketamine, the dextrorotatory enantiomer of ketamine, has been shown to alleviate preoperative anxiety in children effectively. Previous studies have established the effective dose (ED 50 ) of esketamine for reducing anxiety in pediatric patients. However, the 95% effective dose (ED...
Microdosing psychedelics is an increasingly popular phenomenon where small amounts of psychedelic drugs are taken regularly. Qualitative data have been published regarding the experiences of microdosers, but never in the context of a randomised controlled trial. Semi-structured video interviews with 40 healthy males were conducted following a double-blind placebo-controlled trial of 10 µg of...
BMC NursingNovember 6, 2025Sayedeh Farkhondeh Safavi, Hakimeh Vahedparast, Batool Amiri et al.
BACKGROUND: Informal caregivers play a crucial supportive role throughout the course of illnesses, particularly in patients with cancer. Following a cancer diagnosis, informal caregivers often experience substantial psychological, physical, and social stress, which may lead to conditions such as anxiety and sleep disturbances. Therefore, implementing interventions aimed at reducing anxiety and...
Major depressive disorder (MDD) affects approximately 5 % of the global population. Classic psychedelics have shown promise in treating various mental health disorders. This study evaluated the feasibility and tolerability of an 8-week regimen of microdosed lysergic acid diethylamide (LSD) as a treatment for major depressive disorder in an open-label phase 2A trial (LSDDEP1). Nineteen...
Religious and spiritual (R/S) practices and experiences invoke measurable neurocognitive processes that enhance resilience and recovery from affective disorders. Converging evidence from functional neuroanatomy and network studies demonstrate R/S practices recruit brain networks that regulate self-referential processing, salience attribution, executive control, reward, and social bonding....
Postpartum mothers often experience psychological challenges such as stress, anxiety, and feelings of inadequacy, which may be intensified by the pervasive influence of social media. This community service program aimed to enhance the mental health of postpartum mothers in Tuban Regency through the application of mindfulness practices. The program employed a participatory approach involving...
Social anxiety has become a prevalent psychological distress globally, severely impairing individuals’ social functioning and mental health. Existing intervention measures have limitations such as high dependence on professional guidance and poor long-term sustainability, making it urgent to explore innovative and accessible intervention approaches. This study aims to examine the mitigative...
The Apollo wearable device (wrist or ankle) is an investigational device which provides touch therapy with silent vibrations that may help individuals reduce the symptoms of stress such as difficulty breathing, sleeping or focusing on tasks. Positive feedback from a mental health treatment program that uses ketamine-assisted therapy as a treatment adjunct inspired researchers to assess the...
Mindfulness involves the deliberate act of focusing one’s attention on the present moment without making judgments, allowing experiences to unfold naturally. Evidence suggests that practising mindfulness can positively influence mental health, particularly in reducing anxiety. In recent years, the younger generation in India, especially adolescent and young adult students, has been experiencing...
RATIONALE: Chronic cannabis during adolescence is associated with long-lasting pathological outcomes, and these effects can be remarkably different between the sexes. Preclinical studies in rodents demonstrated that sustained exposure to Δ9-tetrahydrocannabinol (THC), induces sex-specific pathophysiological outcomes. Thus, while males exhibit higher vulnerability to schizophrenia-like...