Hanna J Szkudlarek - The Consciousness Library

Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network.

Psychopharmacology November 1, 2025 Marta De Felice, Hanna J Szkudlarek, Matthew J Jones et al.

RATIONALE: Chronic cannabis during adolescence is associated with long-lasting pathological outcomes, and these effects can be remarkably different between the sexes. Preclinical studies in rodents demonstrated that sustained exposure to Δ9-tetrahydrocannabinol (THC), induces sex-specific pathophysiological outcomes. Thus, while males exhibit higher vulnerability to schizophrenia-like...

DOI: 10.1007/s00213-025-06817-8 Full text Anxiety THC Adolescence Females +5

The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats.

Translational Psychiatry October 6, 2025 Hanna J Szkudlarek, Rajkamalpreet Singh Mann, Krystyna Wieczerzak et al. 1 citation

Clinical and pre-clinical evidence demonstrates that adolescent Δ-9-tetrahydrocannabinol (THC) exposure, the primary psychoactive component of cannabis, increases the risk of developing neuropsychiatric symptoms in later life. The medial prefrontal cortex (mPFC) serves as a pathophysiological nexus point underlying many cannabis-related pathophysiological outcomes. Nevertheless, the molecular...

DOI: 10.1038/s41398-025-03580-4 Full text

THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways.

Progress in neuro-psychopharmacology & biological psychiatry January 10, 2021 Hanna J Szkudlarek, Mar Rodríguez-ruiz, Roger Hudson et al.

Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs. CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays antipsychotic and anxiolytic properties. A key brain region responsible for regulation of cognition and affect, the medial prefrontal cortex (PFC), is strongly modulated by cannabinoids, suggesting that these dissociable...

DOI: 10.1016/j.pnpbp.2020.110029 Full text Cannabinoids Latent inhibition Panic Prefrontal cortex

Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors

Neuropsychopharmacology November 27, 2018 Hanna J Szkudlarek, Sagar Desai, Justine Renard et al. 63 citations

The use of cannabis for therapeutic and recreational purposes is growing exponentially. Nevertheless, substantial questions remain concerning the potential cognitive and affective side-effects associated with cannabis exposure. In particular, the effects of specific marijuana-derived phytocannabinoids on neural regions such as the prefrontal cortex (PFC) are of concern, given the role of the...

DOI: 10.1038/s41386-018-0282-7 Full text Cannabidiol Tetrahydrocannabinol Cannabis Anxiety +10

Papers

Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network.

The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats.

THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways.

Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors