Journal of Mental Health and Addiction Nursing
February 19, 2020
Dominique Denis-Lalonde, Andrew Estefan
10 citations
Background Psychedelic-assisted therapy research is demonstrating unprecedented rates of success in treating mental illness, addictions, and end-of-life distress. This psychedelic renaissance is a turning point in how complex human conditions can be treated and has implications for nursing knowledge, advocacy, and practice internationally. Objective This article aims to explore the current...
arXiv Preprint Archive
February 18, 2020
Bartosz Jura
preprint
In this theoretical work the temporal aspect of consciousness is analyzed. We start from the notion that while conscious experience seems to change constantly, yet for any of its contents to be consciously perceived they must last for some non-zero duration of time, which appears to constitute certain conflict. We posit that, in terms of phenomenological analysis of consciousness, the temporal...
Experimental Neurology
February 14, 2020
Sándor Nardai, Marcell J László, Attila Szabo et al.
91 citations
Background and purposeN,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain.MethodsTransient middle cerebral occlusion (MCAO) was induced for 60 min in male Wistar rats...
JMIR Mental Health
February 13, 2020
L. Chavez, K. Kelleher, Natasha Slesnick et al.
Background Homelessness among youth is devastating, with high rates of substance use disorders and mental health comorbidity. Mindfulness-based interventions that include meditation and mindfulness skills training reduce stress and symptoms of anxiety or depression. However, engaging high-risk youth in interventions is challenging. Virtual reality is a more flexible platform for delivering...
Behavioural Brain Research
February 13, 2020
S. Kokane, Ross J. Armant, Carlos A. Bolaños-Guzmán et al.
Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field of psychopharmacology by showing robust, and rapid-acting antidepressant activity in patients suffering from major depressive disorder (MDD), suicidal tendencies, and treatment-resistant depression (TRD). Ketamine’s efficacy, however, is transient, and patients must return to the clinic for repeated...
Journal of Psychopharmacology
February 12, 2020
Tobias Buchborn, Taylor Lyons, Chenchen Song et al.
11 citations
BACKGROUND: Serotonin 2A receptors, the molecular target of psychedelics, are expressed by neuronal and vascular cells, both of which might contribute to brain haemodynamic characteristics for the psychedelic state. AIM: Aiming for a systemic understanding of psychedelic vasoactivity, here we investigated the effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine - a new-generation...
February 12, 2020
Casey O’callaghan
68 citations
This book argues that human perception and perceptual consciousness are richly multisensory. Its thesis is that the coordinated use of multiple senses enhances and extends human perceptual capacities and experience in three critical ways. First, crossmodal perceptual illusions reveal hidden multisensory interactions that typically make the senses more coherent and reliable sources of evidence...
Journal of Ethnopharmacology
February 10, 2020
Lorenzo Leonel Tlacomulco-Flores, M. Déciga-campos, María Eva González-trujano Me et al.
26 citations
ETHNOPHARMACOLOGICAL RELEVANCE Salvia divinorum Epling & Játiva is a Mexican plant used not only in rituals but also in traditional medicine for pain relief. One of the most known bioactive compounds is salvinorin A, which acts centrally in kappa-type opioid receptors. AIM OF THE STUDY Despite its traditional use as a medicinal plant, there is not enough scientific investigation to reinforce...
Scientific Reports
February 10, 2020
Frederick S. Barrett, Manoj K. Doss, Nathan D. Sepeda et al.
375 citations
Psilocybin is a classic psychedelic compound that may have efficacy for the treatment of mood and substance use disorders. Acute psilocybin effects include reduced negative mood, increased positive mood, and reduced amygdala response to negative affective stimuli. However, no study has investigated the long-term, enduring impact of psilocybin on negative affect and associated brain function....
Mindfulness
February 6, 2020
Diane Joss, Sara W. Lazar, Martin H. Teicher
Objectives: Individuals with a childhood maltreatment history tend to have various psychological symptoms and impaired social functioning. This study aimed to investigate the related therapeutic effects of a mindfulness-based intervention in this population. Methods: We analyzed self-report questionnaire scores of the Mindful Attention Awareness Scale (MAAS), Non-Attachment Scale (NAS), Adult...