Nature Communications
August 27, 2026
Chenchen Song, Tinya Chang, Tobias Buchborn et al.
Psilocybin, a psychoactive compound contained in certain mushrooms, can provoke profound psychedelic experiences and also exerts established and controversial therapeutic efficacy in clinical depression and other neuropsychiatric conditions respectively. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the...
bioRxiv : the preprint server for biology
July 6, 2025
Callum M. White, Zohre Azimi, Robert Staadt et al.
1 citation
preprint
Visual perception appears largely stable in time. However, psychophysical studies have revealed that theta waves (4-8 Hz) can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of theta waves to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide...
bioRxiv (Cold Spring Harbor Laboratory)
March 11, 2025
Chenchen Song, Tinya Chang, Tobias Buchborn et al.
4 citations
preprint
Abstract The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by...
International Journal of Molecular Sciences
May 30, 2023
Tobias Buchborn, Taylor Lyons, Chenchen Song et al.
6 citations
(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to be mediated by serotonin 2A receptors on cortical pyramidal cells. The involvement of pyramidal cells in psychedelic-induced shaking behavior remains hypothetical, though, as experimental in vivo evidence is limited. (2)...
bioRxiv (Cold Spring Harbor Laboratory)
September 10, 2020
Irene Mollinedo-Gajate, Chenchen Song, Marcos Sintes-Rodriguez et al.
6 citations
preprint
Abstract Autism spectrum disorder (ASD) is characterized by core deficits in social interaction. The classic serotonergic psychedelic psilocybin has been suggested as a therapeutic agent that may ameliorate in the core symptomology of ASD. We found that the acute response to psilocybin was attenuated in the prenatal valproic acid exposure mouse model of ASD, and importantly, psilocybin rescued...
Journal of Psychopharmacology
February 12, 2020
Tobias Buchborn, Taylor Lyons, Chenchen Song et al.
11 citations
BACKGROUND: Serotonin 2A receptors, the molecular target of psychedelics, are expressed by neuronal and vascular cells, both of which might contribute to brain haemodynamic characteristics for the psychedelic state. AIM: Aiming for a systemic understanding of psychedelic vasoactivity, here we investigated the effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine - a new-generation...