Journal of Psychiatric Research
May 13, 2020
S. Lotfinia, Zohre Soorgi, Y. Mertens et al.
INTRODUCTION There is currently no general agreement on how to best conceptualize dissociative symptoms and whether they share similar neural underpinnings across dissociative disorders. Neuroimaging data could help elucidate these questions. OBJECTIVES The objective of this review is to summarize empirical evidence for neural aberrations observed in patients suffering from dissociative...
The Journal of Antibiotics
May 12, 2020
David E. Nichols
184 citations
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is an indole-based secondary metabolite produced by numerous species of mushrooms. South American Aztec Indians referred to them as teonanacatl, meaning "god's flesh," and they were used in religious and healing rituals. Spanish missionaries in the 1500s attempted to destroy all records and evidence of the use of these mushrooms. Nevertheless,...
ACS Chemical Neuroscience
May 12, 2020
Kodye L. Abbott, Kristina Gill, Patrick Flannery et al.
7 citations
Modern day research, in an attempt to determine the potential therapeutic and adverse effects of illicit substances, is a growing field, but one that faces many regulatory challenges. Due to the potential abuse of illicit substances such as Cannabis, 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD) and psilocybin, regulations have been conceived with the intent of...
Journal of American College Health
May 5, 2020
Claire G. Crowley, L. Kapitula, Dana Munk
Abstract Objective To explore differences in mindfulness, happiness, and perceived anxiety in a sample of college students before and after taking a meditation course. Participants Participants were college students at a primarily undergraduate institution enrolled in an experiential meditation class (n = 74) and a non-meditation class comparison group (n = 73). Methods The study design was a...
Psychopharmacology
May 1, 2020
C Austin Zamarripa, Jennifer E Naylor, Sally L Huskinson et al.
Combinations of mu and kappa opioid receptor (KOR) agonists have been proposed as potential analgesic formulations with reduced abuse liability. The current studies extend previous work by investigating the typical KOR agonist, salvinorin A, and the atypical KOR agonist, nalfurafine, as deterrents of oxycodone self-administration using a progressive ratio (PR) schedule of reinforcement. In...
JAMA Network Open
May 1, 2020
K. Beck, Guy Hindley, Faith Borgan et al.
179 citations
This meta-analysis assesses the psychopathological outcomes in healthy volunteers and patients with schizophrenia treated with ketamine and the experimental factors associated with these findings.
Psychiatria Polska
April 30, 2020
Aleksandra Barabasz-Gembczyk, Krzysztof Kucia
4 citations
Ayahuaska, zwana również „lianą duszy”, „pnączem duszy” to rytualny psychodelik podawany tradycyjnie w formie wywaru roślinnego, od stuleci stosowany przez rdzenną ludność Ameryki Południowej, a w ostatnich 25 latach również w krajach Europy, Azji, Afryki, Australii, w Kanadzie i Stanach Zjednoczonych Ameryki Północnej. Jej aktywność biologiczna wynika z zawartości N,N- dimetrylotryptaminy...
UNC Libraries
April 22, 2020
David E. Nichols
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally considered physiologically safe and do not lead to dependence or addiction. Their origin predates written history, and they were employed by early cultures in many sociocultural and ritual contexts. After the virtually...
Chemical Research in Toxicology
April 20, 2020
I-Hsun Li, Jui-Hu Shih, Ting-Yin Yeh et al.
Methylenedioxymethamphetamine (MDMA) is a psychostimulant with high abuse potential and severe neurotoxicity. According to our previous study, MDMA promotes autophagosome accumulation and contributes to cell death in cultured cortical and serotonergic neurons. However, the detailed mechanism underlying autophagy dysfunction remains unclear. Lysosomes play an important role in autophagic...
April 19, 2020
S. Abdullah, Salmah Jan Noor Muhammad
Shamanism is a way of thinking with an exclusive value. The dependency of Malay society to shamans has been a symbol of their belief. The aim of this research is to identify and analyse the materials used and the methodology of application in shamanic practice by the Malay society. This research employed a qualitative methodology including library research and respondents interview. This...