medRxiv
July 3, 2023
Drummond E-Wen Mcculloch, Anders S. Olsen, Brice Ozenne et al.
20 citations
preprint
A prominent theory of psychedelics is that they increase brain entropy. Twelve studies have evaluated psychedelic effects on fMRI brain entropy quantifications, no findings have been replicated. Here we evaluated these metrics in an independent 28-participant healthy cohort with 121 pre- and post-psilocybin fMRI scans. We assessed relations between brain entropy and plasma psilocin, brain...
Acta Scientific Medical Sciences
July 1, 2023
Yan Naing Soe, Kye Mon Min Swe, Ong Hooi Tin et al.
Background: The essence of teaching-learning practice in Buddhism is based on "Access concentration" and "Vipassana Insight Meditation".The practical process includes the synthesis of the inter-relationship of conditionality, dependent arising and path to purification.Nowadays, "Vipassana Insight Meditation became an interesting practice around the world.The main outcome of "Vipassana Insight...
BMC Psychology
July 1, 2023
Nikos Kogias, Dirk E. M. Geurts, Florian Krause et al.
4 citations
BACKGROUND: Stress-related disorders are a growing public health concern. While stress is a natural and adaptive process, chronic exposure to stressors can lead to dysregulation and take a cumulative toll on physical and mental well-being. One approach to coping with stress and building resilience is through Mindfulness-Based Stress Reduction (MBSR). By understanding the neural mechanisms of...
Canadian Journal of Philosophy
July 1, 2023
Bradford Saad
Abstract Dualism holds that experiences and physical states are distinct in that neither sort of state is identical with or grounded in the other. Cognitive phenomenal realism holds that cognitive experiences are irreducible to sensory experiences. While dualism and cognitive phenomenal realism are logically orthogonal and usually discussed separately, I argue that dualism’s plausibility is...
Biosystems
July 1, 2023
Sergey B. Yurchenko
Is information the other face of causation? This issue cannot be clarified without discussing how these both are related to physical laws, logic, computation, networks, bio-signaling, and the mind-body problem. The relation between information and causation is also intrinsically linked to many other concepts in complex systems theory such as emergence, self-organization, synergy, criticality,...
Brain Network and Modulation
July 1, 2023
Javier Hidalgo Jiménez
2 citations
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated. However, preliminary clinical evidence suggests that DMT and/or...
Journal of integrative medicine
July 1, 2023
Biao Gao, Yi-Cui Qu, Meng-Yu Cai et al.
9 citations
This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD). The Web of Science database (2007-2022) was searched using the search terms "phytochemicals" and "PTSD," and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted. Three hundred and one articles were included in...
FOCUS: The Journal of Lifelong Learning in Psychiatry
July 1, 2023
Jennifer Mitchell, Michael P. Bogenschutz, Alia Lilienstein et al.
97 citations
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for the treatment of patients with...
Naunyn-Schmiedeberg's Archives of Pharmacology
July 1, 2023
Joachim Neumann, Nils Schulz, Charlotte Fehse et al.
13 citations
It is unclear whether bufotenin (= N,N-dimethyl-serotonin = 5-hydroxy-N,N-dimethyl-tryptamine), a hallucinogenic drug, can act on human cardiac serotonin 5-HT4 receptors. Therefore, the aim of the study was to examine the cardiac effects of bufotenin and for comparison tryptamine in transgenic mice that only express the human 5-HT4 receptor in cardiomyocytes (5-HT4-TG), in their wild-type...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
July 1, 2023
Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al.
18 citations
Lysergic acid diethylamide (LSD) is an atypical psychedelic compound that exerts its effects through pleiotropic actions, mainly involving 1A/2A serotoninergic (5-HT) receptor subtypes. However, the mechanisms by which LSD promotes a reorganization of the brain's functional activity and connectivity are still partially unknown. Our study analyzed resting-state functional magnetic resonance...