Molecules
June 24, 2023
Daniela-Mădălina Ciucă Anghel, Gabriela Viorela Nițescu, Andreea-Taisia Tiron et al.
69 citations
Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the negative consequences of drug use. To better understand this complex issue, a review was conducted to examine the mechanisms of action and effects of drugs of abuse, including their acute and chronic effects, the symptoms of abstinence syndrome, as well as their cardiovascular impacts....
bioRxiv Preprint Server
June 23, 2023
Oscar Ferrante, Urszula Gorska-Klimowska, Simon Henin et al.
preprint
Different theories explain how subjective experience arises from brain activity1,2. These theories have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 and Global Neuronal Workspace Theory (GNWT)6–10,...
Feeling Unreal
June 22, 2023
Daphne Simeon, Jeffrey Abugel
Abstract: The social isolation created by the COVID-19 lockdown prompted a dramatic increase in use of the internet, Zoom, and Skype. It also brought greater attention to the subject of internet addiction. New books and studies took a closer look at problematic internet use and issues related to increased time spent online, as well as increased dependence on smartphones for social interaction....
Journal of Clinical Psychology
June 22, 2023
Lisa DeMarni Cromer, Brooke A F Pangelinan, Elissar El Sabbagh et al.
Objective: Retention is challenging in clinical research with pediatric populations. The retention obstacles that are experienced in adult samples are compounded because child samples depend on caregiver support and engagement. The present paper describes retention improvements following protocol adaptations across a pair of cognitive behavioral pilot studies for nightmare sufferers aged 6-17....
Frontiers in Psychology
June 22, 2023
Ignacio Cea
3 citations
Commentary on: Meling D and Scheidegger M (2023) Not in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective. Front. Psychol. 14:1100058. doi: 10.3389/fpsyg.2023.1100058 Word Count: 992 Figures and Tables: none We welcome with great enthusiasm Meling & Scheidegger (2023) (henceforth "M&S") timely contribution to advance an enactive approach to...
Health Sciences
June 22, 2023
Rapolas Šalaševičius, Gabrielė Pakriaušytė
Klasikiniai psichodelikai – tai natūralios (psilocibinas) arba sintetinės (LSD) medžiagos, stimuliuojančios 5-HT2A receptorius ir sukeliančios pakitusias regos, klausos, kognityvines ar nuotaikos būsenas. Šios medžiagos vis dažniau patraukia mokslo tyrėjų bendruomenės dėmesį dėl jų potencialios naudos pacientams, sergantiems įvairaus spektro psichikos sutrikimais. Atlikę literatūros apžvalgą...
Journal of Psychoactive Drugs
June 22, 2023
Bheatrix Bienemann, Amanda Rocha Barbosa, Lucas Villar Magalhães da Cruz et al.
3 citations
There has been growth in the use of psychedelics by the global population in recent years. In addition to recreational and ritualistic use, recent research into psychedelics has brought advances for treating mental disorders. Understanding the specific circumstances in which psilocybin leads to positive outcomes may have important implications for the future of its clinical use and for harm...
Frontiers in Neuroscience
June 22, 2023
Filip Tylš, Čestmír Vejmola, Vlastimil Koudelka et al.
9 citations
Introduction Psilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psychoactivity is mainly attributed to the agonism at 5-HT 2A receptors, it has high binding affinity also to 5-HT 2C and 5-HT 1A receptors and indirectly modulates the dopaminergic system. Psilocybin and its active metabolite psilocin, as well as other...
European Journal of Philosophy
June 21, 2023
Chang Liu
4 citations
Abstract Representationalism is a philosophical position which reduces all phenomenal conscious states to intentional states. However, starting from the phenomenal consciousness, the phenomenal intentionality theory provides an explanation of all sorts of intentionality. Against Michael Shim's interpretation, I argue that, although Hussserl's phenomenology is certainly considered as an antipode...
ACS Chemical Neuroscience
June 21, 2023
Elliot W McClure, R Nathan Daniels
Dextromethorphan (DXM) was introduced in 1958 as the first non-opioid cough suppressant and is indicated for multiple psychiatric disorders. It has been the most used over-the-counter cough suppressant since its emergence. However, individuals quickly noticed an intoxicating and psychedelic effect if they ingested large doses. DXM's antagonism at N-methyl-d-aspartate receptors (NMDAr) is...