Current Topics in Behavioral Neurosciences
July 12, 2025
Wolfgang H. Sommer, Rainer Spanagel
Over a decade after the first edition of "Behavioral Neurobiology of Alcohol Addiction," this chapter revisits the field at a critical juncture, marked by both persistent challenges and emerging opportunities. We reflect on the translational gap that has stalled the development of new treatments for alcohol use disorder (AUD), despite decades of promising preclinical findings. Particular...
CNS Drugs
July 10, 2025
Eric A. Miller, Christy Capone, Erica Eaton et al.
4 citations
Psychedelics have been studied since the 1950s as a potential treatment for alcohol use disorder (AUD), with over a dozen clinical trials of lysergic acid diethylamide (LSD), and several contemporary trials of psilocybin and ayahuasca for this indication. Herein, we characterize foundational studies from the 1950s to the present, with emphasis on key design factors that varied considerably...
Psychiatry Research
July 5, 2025
Maria Helha Fernandes-Nascimento, Priscila Weber, André Brooking Negrão
4 citations
LSD (lysergic Acid Diethylamide), a psychedelic compound, has been investigated in recent studies for the treatment of mental disorders. We analyzed the efficacy and safety of LSD in the treatment of mental disorders and substance use disorders in adult patients. We searched Embase, PubMed, Scopus, PsycINFO, the Cochrane Library, CENTRAL, BVS, EBSCO, Epistemonikos, and the grey literature for...
Psychiatry Research
July 1, 2025
Mazyar Fathi, Mohammad Navid Ebrahimi, Mohammad Banazadeh et al.
6 citations
Neurofeedback (NF), a form of biofeedback, is used to enhance the self-regulation of brain functions by assessing brain activity and delivering feedback signals to ameliorate emotional attributes, cognitive functions, and behaviors. Despite the potential role of NF in substance use disorder (SUD) treatment, a number of gaps such as variations in NF methods persist. This study aims to address...
Social Theory & Health
June 27, 2025
Johan Söderberg, Jakob Lundgren
2 citations
Abstract The controlled substance “ibogaine” is reported to have unique addiction-interrupting properties. Due to its illegal status, the drug's application for treating substance dependency has been explored by a network of addicts and harm reduction activists in underground and off-shore clinics. The article investigates the strategies that practitioners have adopted to mitigate harm from...
Beni-Suef University Journal of Basic and Applied Sciences
June 20, 2025
Danladi Chiroma Husaini, Joel H. Chiroma, Innocent Ejiofor Nwachukwu et al.
Abstract Background Latin America and the Caribbean region are currently faced with the challenges of drug and substance use leading to violence and crime, especially among the younger populations. The complex nature of substance use disorder (SUD), the cost and adverse effects of conventional therapies, the deeply rooted cultural practices of medicinal plants usage, and the abundance of...
Preprints.org
June 19, 2025
Danial Daroui, Andrea Mastrostefano, Flavio Davini et al.
1 citation
preprint
Background: Alcohol Use Disorder (AUD) is a chronic pathological condition with significant burdens throughout the world. Despite the effectiveness of the current pharmacological treatments, the ongoing issues with AUD and the high relapse rates necessitate the exploration of innovative therapies, including the use of psychedelic drugs, which have shown promising initial results. The purpose of...
June 16, 2025
Bruno Ramos Gomes, Bruno Rasmussen Chaves
Ibogaine, derived from the Iboga (Tabernanthe iboga), a shrub of central Africa, has a history of medical and entheogenic ritual use. Its modern use followed the serendipitous discovery, among heroin users in 1962, that it interrupted heroin addiction. Efforts to engage the scientific community in the clinical science of ibogaine had limited success but led to an underground treatment movement...
June 10, 2025
Gabrielle Agin-Liebes, Petros Petridis, Richard J. Zeifman et al.
1 citation
preprint
A recent randomized, double-blind, placebo-controlled, parallel-group trial (NCT02061293) found that psilocybin-assisted therapy significantly improved drinking outcomes compared to an active placebo in adults with alcohol use disorder (AUD). In this secondary analysis, we assessed whether psilocybin-assisted therapy improved self-compassion and whether these changes predicted drinking...
International Journal of Education, Psychology and Counseling
June 5, 2025
Rozeeda Kadri, Zaifuddin Md Rasip
This decade of spiritual meditation is heatedly being discussed among researchers to improve the recovery models of substance addictions such as drugs, marijuana, alcohol and similar existing by incorporating spiritual aspects into a biopsychosocial model. Therefore, the purpose of this paper is to propose a model of substance abuse recovery that needs to be developed so that current patterns...