Current evidence remains insufficient to support the use of psychedelics for substance use disorders in routine clinical practice. Psilocybin has the most supportive data for alcohol use disorder, though it is of moderate quality. The evidence quality is generally low, with significant risk of bias due to poor blinding. Only half of identified studies were RCTs, with 44% conducted over 50 years...
The aim of this study is to examine the correlation between mindfulness and relapse prediction in individuals with substance use disorder. The study was conducted on individuals who were diagnosed with substance use disorders and were receiving at the psychiatry outpatient clinic of a university hospital in Turkey. In the study, 193 individuals with substance use disorders were reached. The...
Background: Opioid use disorder (OUD) is a debilitating health condition that is associated with significant morbidity and mortality in the U.S. While preliminary studies have demonstrated that psilocybin is associated with lowered odds of OUD, current research in this domain suffers from a lack of investigation into the impact of race/ethnicity on this association. Objective: To assess the...
ABSTRACT Background Alcohol Use Disorder (AUD) is a widespread condition with serious health, social, and economic impacts, often marked by relapse despite the availability of FDA-approved treatments. Recent studies suggest that psychedelic substances, such as psilocybin, Lysergic acid diethylamide (LSD), ayahuasca, etc. may offer novel therapeutic potential in treating AUD by modulating...
Substance Use & MisuseMay 1, 2025Corinne L Chandler, Mance E Buttram, Matthew S Ellis1 citation
Data show that recreational ketamine use appears to be increasing. This study aimed to understand how ketamine fits into broader polysubstance use in individuals with opioid use disorder (OUD). Survey data were collected from a sample of treatment-seeking individuals with OUD in March 2022. Of 301 respondents, 28.6% reported lifetime ketamine use. Ketamine use was more frequently reported among...
The objective of the current investigation was to evaluate the efficacy of group counseling that is based on mindfulness-based cognitive therapy and metacognitive therapy in the context of academic procrastination and internet addiction among high school students. A control group was included in the study, which employed a quasi-experimental design with a pretest-posttest-follow-up approach...
TrialsApril 17, 2025Arash Mansoori, Amir Bazrafshan, Jamshid Ahmadi et al.4 citations
The concomitant presence of major depressive disorder (MDD) and opioid use disorder (OUD) poses a formidable clinical challenge, warranting effective interventions that address both psychiatric and addictive components. This study sought to compare the efficacy of adjunctive ketamine and buprenorphine in mitigating anxiety symptom severity and craving intensity in individuals with co-occurring...
AddictionApril 4, 2025Asem Abdelrahman, Mo Belal4 citations
Ketamine-induced cystitis is an increasingly recognized complication associated with the addictive use of ketamine, a dissociative anesthetic. This article provides a comprehensive overview, focusing on its pathophysiology, clinical presentation, diagnosis, management strategies, and implications for addiction treatment. The British Association of Urological Surgeons consensus serves as a...
Substance use disorders (SUDs) are notoriously difficult to treat due to complex biopsychosocial underpinnings and high relapse rates. Recent evidence positions ketamine-assisted psychotherapy (KAP) as a promising intervention for treatment-resistant addiction. This review explores ketamine’s neurobiological mechanisms, its synergistic effect with psychotherapy, and clinical data supporting its...
Objective: This study evaluates the feasibility and acceptability of delivering Mindful Self-Compassion (MSC) to veterans with moral injury and co-occurring PTSD and substance use disorder (PTSD-SUD). Methods: Veterans (N = 26; M age = 50.92; 100% male) were recruited for an 8-week MSC group. Participants completed measures of self-compassion, guilt, shame, PTSD, and substance use outcomes at...