The International Journal of Neuropsychopharmacology
August 1, 2025
S. Ofori, R. Das
Abstract Background Maladaptive motivational memory (MMM) is the term given to a learned association between environmental predictors of reward (cues) and the receipt of rewarding stimuli (reward). A key characteristic of MMMs is that they drive excessive consumption behaviours in a variety of disorders such as substance use disorders (SUDs) and behavioural addictions. MMMs underlie the...
Journal of Substance Use and Addiction Treatment
August 1, 2025
Reinhard Janssen-Aguilar, Shakila Meshkat, Ilya Demchenko et al.
12 citations
Substance Use Disorders (SUDs) involve diminished control, risky use, impaired social interactions, and physical dependence. Despite their global prevalence and burden, treatment options remain limited. Ketamine (KET), an NMDA receptor antagonist, may aid SUD treatment by modulating glutamatergic neurotransmission. This systematic review evaluates KET's role in SUD treatment. This review...
Expert Review of Clinical Pharmacology
July 29, 2025
1. Substance Use Disorder (SUD) continues to have a growing global impact, affecting an estimated 64 million individuals worldwide [1]. While pharmacotherapies are available for opioid, tobacco, an...
Addiction
July 24, 2025
Amandine Luquiens, Dahbia Belahda, Carine Graux et al.
22 citations
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted psychotherapy for patients with comorbid...
International Journal of Community Medicine and Public Health
July 17, 2025
Alanoud K. Albanna, Zayed M. Alnefaie, Atheer M. Saleh et al.
Ketamine’s rapid action and diverse physiological effects have made it an important drug in both anesthesia and mental health treatment. Clinically, it offers unique dissociative anesthetic properties, preserving stable vital signs during sedation and analgesia. Beyond its numbing effect, studies explore its influence on N-methyl-D-aspartate (NMDA) receptors and wider neurochemical systems...
bioRxiv Preprint Server
July 16, 2025
Borjan Milinkovic, Anil K. Seth, Lionel Barnett et al.
2 citations
preprint
Conscious experience depends on the coordinated activity of neural processes that span multiple scales—from synapses to whole-brain dynamics. A recently introduced measure, dynamical independence, identifies, characterises and quantifies these multi-scale relationships using an information-theoretic dimensionality-reduction approach. Here, we use DI to examine changes in emergent dynamical...
Current Topics in Behavioral Neurosciences
July 12, 2025
Wolfgang H. Sommer, Rainer Spanagel
Over a decade after the first edition of "Behavioral Neurobiology of Alcohol Addiction," this chapter revisits the field at a critical juncture, marked by both persistent challenges and emerging opportunities. We reflect on the translational gap that has stalled the development of new treatments for alcohol use disorder (AUD), despite decades of promising preclinical findings. Particular...
CNS Drugs
July 10, 2025
Eric A. Miller, Christy Capone, Erica Eaton et al.
4 citations
Psychedelics have been studied since the 1950s as a potential treatment for alcohol use disorder (AUD), with over a dozen clinical trials of lysergic acid diethylamide (LSD), and several contemporary trials of psilocybin and ayahuasca for this indication. Herein, we characterize foundational studies from the 1950s to the present, with emphasis on key design factors that varied considerably...
Psychiatry Research
July 5, 2025
Maria Helha Fernandes-Nascimento, Priscila Weber, André Brooking Negrão
4 citations
LSD (lysergic Acid Diethylamide), a psychedelic compound, has been investigated in recent studies for the treatment of mental disorders. We analyzed the efficacy and safety of LSD in the treatment of mental disorders and substance use disorders in adult patients. We searched Embase, PubMed, Scopus, PsycINFO, the Cochrane Library, CENTRAL, BVS, EBSCO, Epistemonikos, and the grey literature for...
Psychiatry Research
July 1, 2025
Mazyar Fathi, Mohammad Navid Ebrahimi, Mohammad Banazadeh et al.
6 citations
Neurofeedback (NF), a form of biofeedback, is used to enhance the self-regulation of brain functions by assessing brain activity and delivering feedback signals to ameliorate emotional attributes, cognitive functions, and behaviors. Despite the potential role of NF in substance use disorder (SUD) treatment, a number of gaps such as variations in NF methods persist. This study aims to address...