Pharmacopsychiatry
July 1, 1998
Euphrosyne Gouzoulis‐mayfrank, Frank Schneider, J. Friedrich et al.
16 citations
Human experimental research with hallucinogenic drugs is potentially able to identify linking variables between the psycho(patho)logical conditions and neurobiological alterations involved in both pharmacologically induced and naturally occurring acute psychotic states. A number of methodological aspects should be considered when planning modern experimental studies with hallucinogenic drugs....
Journal of Psychoactive Drugs
June 1, 1997
Evgeny Krupitsky, Alexander Grinenko
241 citations
Ketamine is a prescription drug used for general anesthesia. In subanesthetic doses, it induces profound psychedelic experiences and hallucinations. The subanesthetic effect of ketamine was the hypothesized therapeutic mechanism in the authors' use of ketamine-assisted psychotherapy for alcoholism. The results of a controlled clinical trial demonstrated a considerable increase in efficacy of...
Behavioral Neuroscience
1996
Linda A. Parker
41 citations
The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of...
Nordic Journal of Psychiatry
1996
Jørgen Due Madsen, Asle Hoffart
7 citations
Psychotherapeutic treatment with hallucinogens, usually called psycholytic treatment, was used at Modum Bads Nervesanatorium (MBN) on inpatients from 1961 to 1976. The hallucinogens used were LSD, psilocybin, and CZ 74. The indications and the treatment procedure at MBN are described. From 1961 to 1976, 379 patients received 2205 psycholytic treatments, mostly with LSD. From 1970 to 1976, only...
Annals of the New York Academy of Sciences
October 1, 1990
Errol B. de Souza, George Battaglia, Thomas R. Insel
54 citations
In summary, the data from both neurochemical and neuroanatomical studies demonstrate widespread and long-lasting degeneration of serotonin neurons in brain without any major or consistent effects on catecholamine neurons following in vivo administration of MDMA in both rats and rhesus monkeys. A detailed examination of the parameters involved in the neurotoxic and neurodegenerative effects of...
Crime & Delinquency
July 1, 1972
D F Duncan
1 citation
Psychedelic drugs have been used for individual psychotherapy in prison settings. This paper outlines two studies that explore the use of psychedelic drugs in correction. In 1961 Timothy Leary and Walter Houston Clark administered psilocybin to thirty-three prisoners at the Massachusetts Correctional Insti tution. This program seemed to have positive effects on the inmate-subjects. William H....
Journal of Clinical Psychopharmacology
Ewen Kervadec, Aurore Bezo, Raphaël Serreau et al.
Ibogaine has garnered interest for its potential therapeutic properties in substance use and psychiatric disorders. Unlike classic psychedelics such as psilocybin or LSD, ibogaine remains underexplored in clinical research. This review aimed to synthesize the clinical literature on ibogaine use in humans over the past 3 decades, focusing on outcomes and safety. We conducted a narrative review...
Frontiers in Psychiatry
October 30, 2026
Valerio Ricci, Domenico de Berardis, Giuseppe Maina et al.
Cannabis is the most widely used psychoactive substance subject to legal restriction worldwide, and one of its best-characterized acute effects is a distortion of the lived sense of time: users reliably report that time slows, fragments, or loses its ordinary continuity, an effect documented since the earliest controlled studies of marijuana intoxication and confirmed across decades of...
Research Square
October 29, 2026
Jiaojian Wang, Jin Chen, Wenjie Sun et al.
preprint
Abstract Psilocybin holds strong therapeutic promise for treating major depressive disorder. However, the cellular and molecular substrates underlying its action have not been fully elucidated, especially in the primate brain. We combined multimodal MRI, magnetic resonance spectroscopy (MRS), cerebrospinal fluid (CSF) proteomics and metabolomics, and single-nucleus RNA sequencing (snRNA-seq) to...
Actas Españolas de Psiquiatría
October 29, 2026
Capilla Navarro, Marina Ricco-Pérez, José M. García‐Montes et al.
Background: Psychosis-like experiences (PLEs) are subclinical phenomena situated along the psychosis continuum whose clinical significance depends not only on their occurrence but also on the distress they elicit. Phenomenological frameworks suggest that disturbances in self-experience may constitute a core dimension of vulnerability to PLEs. However, the relationship between social...