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Thomas R. Insel

1 paper in the library · 54 citations · publishing 1990

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Neurotoxic Effects of MDMA on Brain Serotonin Neurons: Evidence from Neurochemical and Radioligand Binding Studiesa

Annals of the New York Academy of Sciences October 1, 1990 Errol B. de Souza, George Battaglia, Thomas R. Insel 54 citations

In summary, the data from both neurochemical and neuroanatomical studies demonstrate widespread and long-lasting degeneration of serotonin neurons in brain without any major or consistent effects on catecholamine neurons following in vivo administration of MDMA in both rats and rhesus monkeys. A detailed examination of the parameters involved in the neurotoxic and neurodegenerative effects of...