Journal of Substance Use
July 30, 2010
R. L. Carhart-Harris, D. J. Nutt
108 citations
This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were submitted. Users were asked to comment on the acute and prolonged effects of different drugs and to provide more specific information on how particular drugs have harmed and/or helped them. Subjects reported relatively less harm associated with the...
Pharmacopsychiatry
August 31, 2009
Torsten Passie
The classification of psychoactive substances (stimulants, entactogens, hallucinogens) in the frame of psychopharmacology was not worked on since the 1960s. Based on the authors empirical and theoretical research about the psychophysical correlates of waking altered states of consciousness, he lecture will present a recently developed new classification of psychoactive substances. Method: The...
Psychopharmacology
April 1, 2009
Lisa E Baker, John J Panos, Bryan A Killinger et al.
57 citations
Research interests regarding the psychopharmacology of salvinorin A have been motivated by the recreational use and widespread media focus on the hallucinogenic plant, Salvia divinorum. Additionally, kappa opioid (KOP) receptor ligands may have therapeutic potential in the treatment of some neuropsychiatric conditions, including drug dependence and mood disorders. Salvinorin A is a selective...
Annals of the New York Academy of Sciences
October 1, 2008
Ronald L Cowan, Deanne M. Roberts, James M. Joers
26 citations
MDMA (3,4 methylenedioxymethamphetamine) has been used by millions of people worldwide as a recreational drug. The terms “MDMA” and “Ecstasy” are often used synonymously, but it is important to note that the purity of Ecstasy sold as MDMA is not certain. MDMA use is of public health concern, not so much because MDMA produces a common or severe dependence syndrome, but rather because rodent and...
Human & Experimental Toxicology
March 1, 2008
R Maciulaitis, Violeta Kontrimaviciūte, Françoise M M Bressolle et al.
102 citations
Ibogaine is an indole alkaloid derived from the bark of the root of the African shrub Tabernanthe iboga. Psychoactive properties of ibogaine have been known for decades. More recently, based on experimental data from animals and anectodal reports in human, it has been found that this drug has anti-addictive effects. Several patents were published between 1969 and 1995. The pharmacology of...
European Journal of Pharmacology
December 15, 2006
Roman Paškulin, Polona Jamnik, Marko Živin et al.
24 citations
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe iboga. It is known to attenuate abstinence syndrome in animal models of drug addiction. Since the anti-addiction effect lasts longer than the presence of ibogaine in the body, some profound metabolic changes are expected. The aim of this study was to investigate the effect of ibogaine on protein expression in rat...
Psychology of Addictive Behaviors
August 28, 2006
Sarah Bowen, Katie Witkiewitz, Tiara M Dillworth et al.
495 citations
Despite the availability of various substance abuse treatments, alcohol and drug misuse and related negative consequences remain prevalent. Vipassana meditation (VM), a Buddhist mindfulness-based practice, provides an alternative for individuals who do not wish to attend or have not succeeded with traditional addiction treatments. In this study, the authors evaluated the effectiveness of a VM...
Addiction
July 15, 2005
Rainer Thomasius, Kay Uwe Petersen, P. Zapletalova et al.
54 citations
ABSTRACT Background Ecstasy use has often been found to be associated with psychopathology, yet this research has so far been based largely on subjective symptom ratings. Aims To investigate whether ecstasy users suffered from long‐term psychopathological consequences. Measurements We compared the prevalence of Diagnostic and Statistical Manual version IV (DSM‐IV) mental disorders in 30 current...
Drugs and Alcohol Today
November 1, 2004
Gary Hayes
Ibogaine is hailed as a miracle cure for addictions, with reports of up to 90% effectiveness, while others talk of violent reactions and an increased potential of overdose. In this overview, we look at its potential as a treatment for addictions. We talk to those who administer it and use it and ask why so little research has been carried out in the UK to establish its safety and uncover...
IUBMB Life
May 1, 2004
Yossef Itzhak, Cindy Achat‐mendes
60 citations
Abstract Methamphetamine (METH) and 3,4‐meythylenedioxymethamphetamine (MDMA; 'ecstasy') are currently major drugs of abuse. One of the major concerns of amphetamines abuse is their potential neurotoxic effect on dopaminergic and serotonergic neurons. Although data from human studies are somewhat limited, compelling evidence suggests that these drugs cause neurotoxicity in rodents and primates....