Frontiers in Molecular Neuroscience
October 21, 2026
Zuzanna Sulej, Magdalena Zielińska
Ketamine has revolutionized psych iatric treatment, challenging monoamine-based paradigms through its capacity for rapid antidepressant action. While N-methyl-D-aspartate receptor (NMDAR) antagonism remains the canonical mechanism, this integrative review proposes a multi-receptor, neuron–glia convergence model to help account for ketamine's therapeutic efficacy. We outline the well-established...
Journal of postgraduate institute of pali and buddhist studies.
October 21, 2026
Neha Malhotra
This paper examines the relationship between interbeing and compassion in the thought of Thích Nhất Hạnh. It places his teachings within the wider framework of Buddhist philoso-phy by considering selected writings of Thích Nhất Hạnh alongside relevant classical Buddhist sources. Interbeing is understood as a relational view of existence in which all phenomena are interconnected and the self...
October 21, 2026
Joshua Cain, Micah Alan Johnson, Amirvala Tavakoli et al.
preprint
Sustained contemplative practice confers well-documented psychological and physiological benefits, yet the experiential deepening that motivates practitioners can require many hours of practice, and mastery is not assured. Methods that accelerate training would broaden access to these benefits and could also test mechanism: the posterior cingulate cortex (PCC), caudate, and anterior insula are...
Zenodo (CERN European Organization for Nuclear Research)
October 21, 2026
Kwan Hong Tan
preprint
The hard problem asks why physical processes are accompanied by experience. This paper develops a calibration audit for a prior evidential question: whether observations identify a psychophysical correspondence. Reference-relative hypotheses are separated from conventional relabellings. Finite reconstruction results characterize bridge ambiguity, and joint channel transformations show why...
Zenodo (CERN European Organization for Nuclear Research)
October 21, 2026
Sérgio da Silva
preprint
AbstractThe emergence of consciousness cannot be read directly from a birth date, a behavioral milestone, or a single neural response. This critical narrative review examines what developmental neuroscience can establish about subjective experience in fetuses, newborns, and young infants, drawing on literature available through 20 October 2026. It distinguishes the capacity for experience from...
Zenodo (CERN European Organization for Nuclear Research)
October 21, 2026
Shannon Green
preprint
Endogenous N,N-dimethyltryptamine (DMT) has been detected in mammals, but its physiological functions and the distribution of functionally relevant synthesis remain unresolved. This paper proposes prostatic tissue as a candidate peripheral site of synthesis. Oncology studies document indolethylamine N-methyltransferase (INMT) expression in human prostate samples, including adjacent...
Psychedelic Medicine
October 21, 2026
Michael D. Masucci, Alex S. Cohen, Christopher R. Cox et al.
Background: Within the last decade, ayahuasca, a brew containing a serotonin 2A receptor agonist (i.e., a classical psychedelic compound), has received increased attention as a possible intervention for posttraumatic stress disorder. Ayahuasca has demonstrated potential for long-term symptom reduction, but the biobehavioral changes caused by ayahuasca have not been defined quantitatively or...
October 20, 2026
John L. Schellenberg
Abstract Chapter 7 shifts from realism and knowledge to mind, arguing that stage-sensitive reasoning both clarifies and reshapes the problem of consciousness and undermines Colin McGinn’s influential pessimism about its ultimate tractability. It proposes a “separative” approach, according to which the traditional problem is best understood as a bundle of distinct questions, only some of which...
October 20, 2026
María Laura Gorosito, Matías Rodolfo Pretel, Nerea L Herrero et al.
preprint
Dreams often incorporate recent waking experiences, but whether the relationship between dream content and subsequent memory depends on the state of the memory before sleep remains unclear. In this exploratory study, fifteen participants learned novel word-definition-image associations across a four-day home-based protocol. Dream reports were collected after serial awakenings following initial...
International Journal of Molecular Sciences
October 20, 2026
Thainá P Souza, Andrés Rodríguez-Vega, A. C. Dutra-Tavares et al.
Schizophrenia and nicotine misuse comorbidity frequently emerges during adolescence. Although the dorsal striatum has received less attention than mesolimbic regions in this context, growing evidence supports its involvement in both schizophrenia-related dysfunction and the transition to compulsive drug-seeking. Here, we investigated dorsal striatal proteomic alterations in adolescent male and...