LSD produces place preference and flavor avoidance but does not produce flavor aversion in rats.
Behavioral Neuroscience 1996 DOI: 10.1037//0735-7044.110.3.503 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical place conditioning and taste reactivity paradigms) |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | 0.05 to 0.2 mg/kg |
| Topics | Addiction LSD Serotonin |
| Keywords | Conditioning Flavor Taste aversion Conditioned place preference Preference test Reactivity psychology Pharmacology Food science Biochemistry |
| Citations | 41 |
| Key findings | LSD produces conditioned place preference only at the highest dose (0.2 mg/kg) and induces taste avoidance without producing taste aversion, suggesting a mechanism distinct from emetic drugs. |
Abstract
The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of 0.05 to 0.2 mg/kg of LSD produced taste avoidance, but no dose of LSD produced an aversion to the taste as assessed by the taste reactivity test. These results suggest that LSD, like other rewarding drugs, produces taste avoidance by a mechanism other than that produced by emetic drugs.
Comparable studies
Other preclinical and animal studies on LSD for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse Male and female rats | 2020 | Preclinical animal study | |
| BEHAVIORAL AND ELECTROPHYSIOLOGICAL EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) IN A MOUSE MODEL OF ALCOHOL USE DISORDER (AUD) 8-week-old male C57BL6/J mice, including an alcohol-exposed group and a control group | 2025 | Preclinical translational study in mice |
Citations in the library
Cited by 9
- Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology May 1, 2005
- Use and abuse of dissociative and psychedelic drugs in adolescence Pharmacology, Biochemistry, and Behavior January 27, 2021
- Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine. Progress in Neuro-Psychopharmacology and Biological Psychiatry February 1, 2002
- Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task Frontiers in Pharmacology December 3, 2020
- The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review. CNS Drugs December 1, 2023
and 4 more in the library