Annals of the New York Academy of Sciences
October 1, 2004
Yossef Itzhak, Karen L. Anderson, Syed F. Ali
31 citations
A bstract : It has been shown that mice deficient in neuronal nitric oxide synthase (nNOS) gene are resistant to cocaine‐induced psychomotor sensitization and methamphetamine (METH)‐induced dopaminergic neurotoxicity. The present study was undertaken to investigate the hypothesis that nNOS has a major role in dopamine (DA)‐ but not serotonin (5‐hydroxytryptamine; 5‐HT)‐mediated effects of...
IUBMB Life
May 1, 2004
Yossef Itzhak, Cindy Achat‐mendes
60 citations
Abstract Methamphetamine (METH) and 3,4‐meythylenedioxymethamphetamine (MDMA; 'ecstasy') are currently major drugs of abuse. One of the major concerns of amphetamines abuse is their potential neurotoxic effect on dopaminergic and serotonergic neurons. Although data from human studies are somewhat limited, compelling evidence suggests that these drugs cause neurotoxicity in rodents and primates....
Nitric oxide : biology and chemistry
August 2003
Karen L. Anderson, Yossef Itzhak
Repeated exposure to psychostimulants such as cocaine and amphetamines results in behavioral sensitization, a paradigm thought to be relevant to drug craving and addiction in humans. We have previously shown that the induction, expression, and maintenance of psychomotor sensitization to cocaine, methamphetamine, and methylphenidate (indirect dopamine agonists) are blocked by co-administration...
Annals of the New York Academy of Sciences
May 1, 1998
Yossef Itzhak, Syed F. Ali
20 citations
Although the alkaloid ibogaine is a potent hallucinogenic agent some indications suggest that it may be useful for the treatment of opioid and cocaine addiction. The neurochemical mechanism(s) underlying ibogaine effects remain unclear. In the present study we investigated the interaction of ibogaine with the phencyclidine (PCP) site located in the ionophore of the N-methyl-d-aspartate (NMDA)...
Life Sciences
1990
Yossef Itzhak, Ira D. Stein
99 citations
An increasing amount of evidence suggests the existence of specific binding sites for psychotomimetic drugs from the opiate-benzomorphan and arylcyclohexylamine series. The sigma binding sites have preferential affinity for the dextrorotatory isomers of certain opiate benzomorphans, such as (+)SKF 10047, (+)cyclazocine and (+)pentazocine and also for some neuroleptics (e.g., haloperidol). The...