Human & Experimental Toxicology
March 1, 2008
R Maciulaitis, Violeta Kontrimaviciūte, Françoise M M Bressolle et al.
102 citations
Ibogaine is an indole alkaloid derived from the bark of the root of the African shrub Tabernanthe iboga. Psychoactive properties of ibogaine have been known for decades. More recently, based on experimental data from animals and anectodal reports in human, it has been found that this drug has anti-addictive effects. Several patents were published between 1969 and 1995. The pharmacology of...
Journal of Liquid Chromatography & Related Technologies
March 1, 2007
Violeta Kontrimaviciūte, Olivier Mathieu, Laurence Balas et al.
7 citations
Abstract The aim of this study was: i) to carry out a structural analysis of ibogaine and noribogaine, ii) to identify products formed under light exposure (daylight or 254 nm, 20°C) of the two drugs in methanolic solutions, and iii) to examine the alkaloid contents of a specimen of root bark of the Tabernanthe iboga shrub using liquid chromatography‐electrospray mass spectrometry. After...
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
November 7, 2006
Violeta Kontrimaviciūte, Hélène Breton, Olivier Mathieu et al.
27 citations
A liquid chromatography/electrospray ionization mass spectrometry (LC-ESI-MS) method was developed for the first time for the determination of ibogaine and noribogaine in human plasma and whole blood. The method involved solid phase extraction of the compounds and the internal standard (fluorescein) from the two matrices using OasisHLB columns. LC separation was performed on a Zorbax eclipse...
Journal of Analytical Toxicology
September 1, 2006
Violeta Kontrimaviciūte, Olivier Mathieu, Jean-Claude Mathieu-Daudé et al.
38 citations
In the present paper, we report for the first time the tissue distribution of ibogaine and noribogaine, the main metabolite of ibogaine, in a 48-year-old Caucasian male, with a history of drug abuse, found dead at his home after a poisoning involving the ingestion of root bark from the shrub Tabernanthe iboga. Ibogaine and noribogaine were quantified in tissues and fluids using a fully...
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
August 5, 2005
Violeta Kontrimaviciūte, Michel Larroque, Vitalis Briedis et al.
A high-performance liquid chromatographic (HPLC) method with fluorimetric detection was developed for the simultaneous determination of ibogaine and noribogaine in human plasma using fluorescein as internal standard. This method involved a solid phase extraction of the compounds from plasma using N-vinylpyrrolidone-divinybenzene copolymer cartridges. Separation of the three analytes was...