Psychotherapy and Psychosomatics
June 19, 2026
Judith Rohde, Tyler M Moore, Kathryn Walker et al.
Ketamine combined with psychotherapy has shown promise in treating posttraumatic stress disorder (PTSD), but predictors of clinical benefit remain unclear. In this systematic review and individual participant data meta-analysis (IPDMA), we examined patient- and treatment-level predictors of PTSD symptom change after combined treatment. Eligible studies combined ketamine with psychotherapy in...
J Clin Sleep Med
June 17, 2026
Efficacy of imagery rehearsal therapy in the treatment of traumatic nightmares in youth with complex post-traumatic stress disorder.
Journal of Medical Internet Research
June 17, 2026
Acacia C Parks, Amanda L Woodward, Robert D Henry et al.
Background: Depression, anxiety,, and PTSD are leading global causes of disability. Standard interventions utilize slow mechanisms of action, high attrition, and significant accessibility barriers. While intravenous (IV) and intranasal ketamine are rapid-acting alternatives, high cost and intensive logistical requirements limit adoption. Sublingual (SL) at-home ketamine addresses some gaps but...
Journal of Health Wellness and Community Research
June 16, 2026
Saba Naz, Bakht E Karam, Wahaj Ahmad Khan et al.
Background: Post-traumatic stress disorder is frequently accompanied by persistent anxiety, hyperarousal, sleep disturbance, and impaired emotional regulation. Mindfulness-based interventions may support trauma-exposed patients by improving present-moment awareness, distress tolerance, and regulation of intrusive thoughts and bodily arousal. Objective: This study evaluated whether an eight-week...
Scientific Reports
June 14, 2026
Bar Eilat Yogev, Gal Levi, Noa Efroni et al.
Alcohol consumption before trauma is a prevalent but understudied risk factor for posttraumatic stress disorder (PTSD). This study investigated whether acute ethanol exposure prior to trauma modulates PTSD-like symptom development in rats, identified hippocampal mechanisms involved, and tested an early post-trauma intervention. Adult male Sprague-Dawley rats received ethanol (1.6 g/kg, 40% v/v,...
Psychoactives
June 8, 2026
Fizza Mitter, Anton Sheptooha, Janni Leung et al.
Post-traumatic stress disorder (PTSD) remains inadequately treated by existing pharmacological and psychological interventions, prompting growing interest in psychedelic-assisted psychotherapy. Although randomised controlled trials have evaluated several psychedelic agents for PTSD, to our knowledge, no prior PTSD-specific synthesis has quantitatively examined multiple agent classes within a...
Scientific Reports
June 5, 2026
Amaury C Mengin, Julie Rolling, Walid Oulehri et al.
Intensive Care Unit (ICU) hospitalizations confront individuals with imminent death and may cause post-traumatic stress disorder (PTSD). In contrast, traumatic events may lead to positive psychological outcomes such as post-traumatic growth. As consciousness is altered, near-death experiences (NDEs) may occur and be associated with post-traumatic growth. Our cross-sectional, monocentric study...
European Psychiatry
June 1, 2026
W. Aldulaimy, A. Shah
Introduction TBI patients often suffer from severe, treatment-resistant depression and PTSD. Ketamine shows promise in non-TBI populations, but its efficacy in TBI patients needs exploration for efficacy and tolerability. Objectives Evaluate ketamine’s clinical effectiveness and safety (PHQ-9, GAD-7, PCL-5 scores) in post-TBI patients, comparing IM, intranasal, and oral routes. Methods Design:...
Molecular Psychiatry
June 1, 2026
Xin Yi, Yuan-Bo Zhang, Tong-Zhou Yu et al.
Post-traumatic stress disorder (PTSD) persists when stress biases memory systems-broadening threat engrams, weakening context-appropriate inhibition, and rendering extinction fragile. Integrating preclinical and human evidence, we argue that these liabilities are tractable within a circuit-informed framework that aligns behavioral procedures with the biology of fear memory. Extinction can be...
Public health challenges
June 1, 2026
Alishba Javaid, Rabi Jan, Afifa Khan et al.
Sleep paralysis (SP) is a parasomnia disorder connected to being unable to move your body though the experiencing person remains conscious. Factors involving this disorder are stress, post-traumatic stress disorder (PTSD), lifestyle factors including the amount of sleep, and the amount of caffeine consumed. Our study aim is to assess the symptoms, duration, time of occurrence, and body position...
Journal of trauma and injury
June 1, 2026
Minaal Ahmed Malik, Michele Halasa, Jack Chia et al.
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used in trauma and emergency medicine for its rapid analgesic and sedative properties. While its efficacy in acute pain management is well established, concerns persist regarding its long-term psychological effects, particularly its potential role in the development of posttraumatic stress disorder (PTSD). Some studies...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
June 1, 2026
Ted Obi, Kerry J. Ressler
Post-traumatic stress disorder (PTSD) remains one of psychiatry's most challenging disorders, common, disabling, and biologically complex. Despite decades of research, only sertraline and paroxetine are FDA-approved, both with modest efficacy. Even first-line trauma-focused psychotherapies leave up to half of patients with persistent symptoms. However, advances in neurobiology are reframing...
Journal of Traumatic Stress
June 1, 2026
Kadek Suhardita, Veno Dwi Krisnanda, Rikas Saputra et al.
In this commentary on Morland et al. (2026)'s recent State of the Science article on 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder (PTSD), we aim to emphasize both MDMA's therapeutic promise and its unresolved scientific challenges. Although recent trials on MDMA-assisted interventions have reported encouraging reductions in PTSD symptoms, the...