Molecular Psychiatry
June 27, 2026
David R. Roalf, Tyler M Moore, Jacquelyn Stifelman et al.
Abstract Cannabis use is linked to elevated psychosis risk, yet the neurobiological mechanisms that couple use to symptom expression remain unclear. Because glutamatergic dysregulation has been implicated in both cannabis effects and psychosis vulnerability, we examined whether brain glutamate relates to dimensional symptoms as a function of cannabis use across the psychosis spectrum....
Psychotherapy and Psychosomatics
June 19, 2026
Judith Rohde, Tyler M Moore, Kathryn Walker et al.
Ketamine combined with psychotherapy has shown promise in treating posttraumatic stress disorder (PTSD), but predictors of clinical benefit remain unclear. In this systematic review and individual participant data meta-analysis (IPDMA), we examined patient- and treatment-level predictors of PTSD symptom change after combined treatment. Eligible studies combined ketamine with psychotherapy in...
Journal of Affective Disorders
July 15, 2025
Tyler M Moore, Kathryn Walker, Emma Tung et al.
8 citations
Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like psychotherapy typically require weeks to show effects. This study investigated whether combining ketamine with psychotherapy produces greater symptom improvement...
JAMA Psychiatry
June 1, 2018
J. C. Scott, Samantha T. Slomiak, Jason D. Jones et al.
Importance Substantial shifts in perception and policy regarding cannabis have recently occurred, with use of cannabis increasing while its perceived harm decreases. One possible risk of increased cannabis use is poorer cognitive functioning, especially in youth. Objective To provide the first quantitative synthesis of the literature examining cannabis and cognitive functioning in adolescents...
Psychology of Addictive Behaviors
April 17, 2017
J. Scott, Daniel H. Wolf, Monica E. Calkins et al.
Cannabis use in youth is rising and has been linked to deficits in cognitive functioning. However, cognitive findings have primarily been based on small samples of users seeking treatment, and few studies have evaluated cognition in occasional cannabis users. Here, we examined 4,568 adolescents and young adults (ages 14–21 years) drawn from the Philadelphia Neurodevelopmental Cohort, a...