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Research Square

ISSN 2693-5015

191 papers in the library · 84 citations · publishing 2020-2026

Papers

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Developing and testing the effectiveness of mindfulness intervention for reducing loneliness in Hong Kong older adults: A hybrid sequential multiple assignment randomized trial, micro randomized trial experimental design study protocol

Research Square June 11, 2026

Developing and testing the effectiveness of mindfulness intervention for reducing loneliness in Hong Kong older adults: A hybrid sequential multiple assignment randomized trial, micro randomized trial experimental design study protocol

DOI: 10.21203/rs.3.rs-9845879/v1 (opens in new tab)

Intentions might matter in unexpected ways: A nuanced exploration of psychedelic intentions beyond their type

Research Square June 9, 2026 Iryana Mosina, David Luke

Abstract Background . It is widely accepted that beyond the pharmacological predictors, individuals’ pre-drug mental disposition, including intentions , influences the psychedelic experience. However, is it not fully clear how intentions and outcomes relate. This study explores the intention qualities beyond classically assessed category and explicitness in association with outcomes. Methods ....

DOI: 10.21203/rs.3.rs-9966224/v1 (opens in new tab) Full text (opens in new tab) Centrality Association psychology Realisation Emotional reaction +5

Symptom-Specific Nuances in Psychedelic Integration: A Qualitative Study of Insights from Therapists Supporting Extended Difficulties in Naturalistic Settings

Research Square May 21, 2026 Ali Wright, David Luke, Oliver Robinson et al.

Abstract Background Psychedelic consumption in naturalistic settings is rising, and a significant minority of users experience extended psychological difficulties. Yet, research exploring these challenges remains limited. Despite widespread endorsement of integration practices, little is known about how therapists approach integration for heterogeneous extended difficulties. Methods Nineteen...

DOI: 10.21203/rs.3.rs-9448195/v1 (opens in new tab) Full text (opens in new tab)

Child and maternal health outcomes following antenatal exposure to classic psychedelic substances: a systematic review.

Research Square May 19, 2026 Sunjuri Sun, Claudia Hanson, Peter S. Hendricks et al.

As the cultural, scientific, and legal landscape surrounding psychedelics continues to shift toward greater access and acceptability, it is likely that increasing numbers of women of reproductive age may be exposed to these substances. Despite this, the evidence on antenatal exposure has not been systematically reviewed. To synthesize the human literature on child and maternal outcomes...

DOI: 10.21203/rs.3.rs-9732799/v1 (opens in new tab) Full text (opens in new tab) Obstetrics Perinatal outcomes Population health Pregnancy +3

Adolescents’ and Young Adults’ Integration Processes for Extended Difficulties Following Challenging Psychedelic Experiences: A Qualitative Investigation

Research Square May 14, 2026 Sam Barfoot, David Luke, Oliver Robinson et al.

Abstract Background As interest in psychedelics grows, concerns remain about ethical use and the documentation of adverse psychological effects. Use is increasing, yet long-term challenges - particularly among adolescents and young adults - are under-researched. This group is especially vulnerable, highlighting the need to understand how psychedelic-related challenges are experienced in...

DOI: 10.21203/rs.3.rs-9668424/v1 (opens in new tab) Full text (opens in new tab) Mindfulness Psychoeducation Thematic analysis Qualitative research +9

Safety and Efficacy of Psilocybin in the Management of Treatment-Resistant Depression: A Systematic Review

Research Square May 11, 2026 Chloë K Walters, Sarentha Chetty, Thankhoe A Rants’o et al.

Abstract Background: Conventional pharmacotherapy for treatment-resistant depression (TRD) has been found to provide limited benefit in a subset of patients. Psilocybin‑assisted therapy has emerged as a promising modality due to its rapid‑acting antidepressant effects and favourable tolerability profile shown in early trials. Despite growing research interest in psilocybin‑assisted therapy the...

DOI: 10.21203/rs.3.rs-9283280/v1 (opens in new tab)

APOE ε4-related structural vulnerability in mild cognitive impairment: a subsystem-based analysis of the default mode network.

Research Square May 11, 2026 Xiaoming Yang, Jian Lyu, Jubo Wang et al.

Mild cognitive impairment (MCI) is a critical prodromal stage of progressive cognitive decline. As a core cognitive brain network, the default mode network (DMN) exhibits structural alterations in MCI that are closely associated with cognitive impairment. Apolipoprotein E ε4 (APOE ε4), the strongest genetic risk factor for pathological cognitive decline, has been shown to disrupt the structural...

DOI: 10.21203/rs.3.rs-9447482/v1 (opens in new tab) Full text (opens in new tab) Default mode network Apolipoprotein e ε4 Dorsomedial prefrontal cortex Mediation analysis +2

Methamphetamine-Fentanyl Polysubstance Administration Produces Social Deficits and Corticolimbic Stress-Reward Circuit Adaptations.

Research Square April 23, 2026 Leah M Salinsky, Joshua L Fox, Kyra C Diaz et al.

Polysubstance use involving psychostimulants and opioids is increasingly prevalent and associated with elevated overdose risk, relapse vulnerability, and poor treatment outcomes. However, the neurobehavioral consequences of opioid-stimulant use remain poorly understood. We evaluated whether repeated methamphetamine-fentanyl polysubstance treatment disrupts social preference during withdrawal,...

DOI: 10.21203/rs.3.rs-9306429/v1 (opens in new tab) Full text (opens in new tab) Addiction Psilocybin Crhr1 Fentanyl +6

Extended difficulties after psychedelic experiences: Prevalence and associations in a global, multilingual sample.

Research Square April 8, 2026 Oliver Robinson, David Luke, Jules Evans et al. 1 citation

As psychedelic use increases and integrates with mainstream medicine, understanding the prevalence and nature of postpsychedelic adverse outcomes is critical. We investigated extended difficulties after psychedelic use via the Global Psychedelic Survey (GPS) 2025, which is a multilingual online survey of people who have used psychedelics. Data on the prevalence, characteristics, and...

DOI: 10.21203/rs.3.rs-9304959/v1 (opens in new tab) Full text (opens in new tab) Global psychedelic survey Adverse reaction Challenging experiences Extended difficulties +1

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC

Research Square March 31, 2026 Marcus W. Meinhardt, Ivan Skorodumov, Florian Walter et al.

Abstract Alcohol use disorder is a major global health problem, and current treatments often fail to produce lasting reductions in harmful drinking1,2. Psychedelic-assisted therapies may promote durable behavioural change by enhancing brain plasticity during emotionally meaningful experiences, but progress has been limited by a lack of experimental models that capture these context-dependent...

DOI: 10.21203/rs.3.rs-9103509/v1 (opens in new tab) Neuroplasticity Alcohol use disorder Addiction Glutamatergic +7