Molecular Psychiatry
September 19, 2026
Dijia Wang, Junnan Xu, Zhaoran Wang et al.
Hallucinations are a core feature of several psychiatric disorders, but the circuit mechanisms that separate perception from behavioral output remain poorly defined. Here, we combined an auditory discrimination task with AI-based pose analysis to quantify S-ketamine-induced false auditory threat responses and behavioral disorganization in mice. Control assays, including sucrose preference, loss...
Translational Psychiatry
March 6, 2026
Huimin Zhu, Qingfeng Wei, Shuang Xu et al.
1 citation
Postoperative depression adversely influences breast cancer patients' clinical outcomes. Our prior study demonstrated that intraoperative esketamine ameliorated postoperative depression in breast cancer patients, yet the underlying neural mechanism remains incompletely understood. We performed a double-blind randomized controlled trial in 35 breast cancer patients with preoperative depressive...
Drug Design, Development and Therapy
March 1, 2026
Meng-Meng Li, Qingfeng Wei, Qian-Yun Zhu et al.
Combined low-dose dexmedetomidine and esketamine during cesarean section provides a short-term improvement in early postpartum depressive symptoms, reduces intraoperative neuropsychiatric adverse events, and enhances maternal satisfaction, with a favorable maternal and neonatal safety profile.
Journal of clinical anesthesia
April 1, 2025
Qingfeng Wei, Mengmeng Li, Qiuling Du et al.
10 citations
To determine whether intraoperative low-dose esketamine ameliorates depression in women having breast cancer surgery. A prospective single-center double blind randomized placebo-controlled trial. Perioperative period, operating room, post anesthesia care unit and hospital ward. 108 women 18-65 years old who were scheduled for elective breast cancer surgery. All had preoperative depressive...
Therapeutics and clinical risk management
2025
Xuemei Sun, Qiuling Du, Yongjie Liang et al.
5 citations
Postoperative fatigue (POF) is a common occurrence following colonoscopy, primarily attributed to bowel preparation and endoscopic probe stimulation, and is associated with worse postoperative outcomes. Esketamine, an antidepressant anesthetic, has shown the potential to enhance postoperative recovery through various mechanisms. We hypothesized that the low-dose esketamine could alleviate POF...
BMJ Open
September 25, 2023
Cen Chen, Qingfeng Wei, Jiajia Zhu et al.
7 citations
Introduction Depressive symptoms have surfaced as the principal mental health concern among patients with breast cancer, with surgical interventions potentially exacerbating these symptoms and adversely influencing clinical outcomes. This study protocol is designed to investigate the efficacy of low-dose esketamine administered perioperatively on depressive symptoms in patients with breast...