January 31, 2024
Joshua Cain, Tracy Brandmeyer, Ninette Simonian et al.
9 citations
preprint
Focused ultrasound stimulation of the caudate nucleus significantly improves self-reported meditative depth and mood in experienced vipassana meditators, and is accompanied by reduced heart rate and increased heart rate variability. These physiological changes strongly correlate with reported depth, suggesting a mechanistic link between reduced arousal and successful meditation. Stimulation of the posterior cingulate cortex or insula did not produce similar effects. The findings indicate that targeted neuromodulation may help lower the barrier to consistent meditation practice for novice or intermediate meditators.
Journal of Cognitive Neuroscience
May 14, 2025
Ruby M. Potash, Sean D. Van Mil, Mar Estarellas et al.
7 citations
During an advanced concentrative absorption meditation called jhana, characterized by highly stable attention and mental absorption, the brain's nonoscillatory dynamics—captured by nonlinear connectivity metrics—distinguish the meditative state better than oscillatory synchrony. Combining attention-related phenomenological ratings with these nonlinear metrics improves the detection of the meditative state compared to using neural data alone. Deeper absorption states show an equalization of feedback and feedforward processes, suggesting a balance between internally and externally driven information processing. The findings, based on EEG recordings from a single meditator with over 20,000 hours of practice across 29 sessions, offer initial insights into the distinct neural dynamics of refined conscious states.
George Deane, Jonas Mago, Aikaterini Fotopoulou et al.
7 citations
preprint
A computational theory called adaptive narrative control explains how subpersonal processes shape conscious experience to enable adaptive behavior. Systems with an attention schema can anticipate the epistemic and pragmatic consequences of attentional states, using mental action—endogenous control of attention—to regulate affective states. This capacity also produces avoidant mental action or motivated inattention, which is argued to be a core mechanism underlying psychopathology, leading to rigid belief formation, reduced emotional recognition (alexithymia), and decreased subjective well-being under certain environmental conditions. The account partially echoes Freudian defense mechanisms and introduces a computational unconscious. It refines the REBUS model of psychedelic therapy and explains improvements in well-being from meditation.
Mindfulness
July 29, 2025
Terje Sparby, Matthew D. Sacchet
6 citations
Advanced meditation can lead to a transformative process resembling a metaphorical death and rebirth, where an old identity dissolves and a new one emerges. This process, described in detail by the Burmese meditation master Mahāsī Sayādaw, is associated with access to bliss, peace, wisdom, and the reduction of suffering—states regarded as ultimate aims of human life. While scientific research has measured certain aspects of human development, inner development related to advanced meditation has been neglected. The authors propose an outline of this death-and-rebirth process to provide a foundation for scientific investigation of meditative development and a deeper understanding of human potential.
Biological psychiatry. Cognitive neuroscience and neuroimaging
April 1, 2025
Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al.
6 citations
Meditation practices, which have shown therapeutic benefits for conditions like depression, pain, addiction, and anxiety, have been studied with neuroimaging over the past decade. However, existing neuroscientific models are based on small, heterogeneous datasets, limiting generalizability and replicability. The ENIGMA-Meditation consortium is the first worldwide collaborative effort to conduct systematic meta- and mega-analyses of globally distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and address multidomain heterogeneity in meditation practice types, experience, and experimental design. The consortium will generate rigorous neuroscientific insights into the mechanisms underlying meditation's therapeutic effects on psychological and cognitive attributes.
Network neuroscience (Cambridge, Mass.)
January 1, 2025
Isaac N Treves, Winson F.z. Yang, Terje Sparby et al.
6 citations
Advanced meditation involves states and stages that develop with experience. A case study using 7-T fMRI and dynamic functional connectivity analysis of a meditator practicing jhāna advanced absorptive concentration meditation (ACAM-J) identified three distinct brain states: a default-mode network (DMN)-anticorrelated state, a hyperconnected state, and a sparsely connected state. The DMN-anticorrelated state was more prevalent during ACAM-J than control conditions and increased with deeper meditation. The hyperconnected state, marked by elevated thalamocortical and somatomotor connectivity, was also more common during ACAM-J but decreased over the session, corresponding to reports of wider attention and reduced physical sensations. This suggests that functional neuroimaging can track the dynamics of altered states of consciousness in advanced meditators.
October 19, 2023
Leonardo Christov-Moore, Félix Schoeller, Caite Lynch et al.
6 citations
preprint
Aesthetic chills—the pleasurable, cold sensation often experienced during music or film—are robustly linked to self-transcendence, a positive altered state involving ego-dissolution, connectedness, and moral elevation. In 2,937 participants exposed to chills-eliciting stimuli, chills occurrence and intensity formed a tightly interrelated construct with measures of self-transcendence, even after controlling for prior state and trait differences. The findings suggest that self-transcendence experiences can be reliably evoked through exposure to audiovisual media that elicit chills, offering a more accessible path to study and apply self-transcendence for well-being and prosociality compared to conventional methods like meditation or psychedelics.
Cerebral cortex (New York, N.Y. : 1991)
April 1, 2025
Umay Demir, Winson Fu Zun Yang, Matthew D. Sacchet
5 citations
Advanced concentrative absorption meditation known as jhana (ACAM-J) disrupts the brain's typical hierarchical organization, shifting functional gradients toward a more globally integrated state between sensory and higher-order cognitive regions. It also increases differentiation between sensory-related and attention modulation-related areas, consistent with meditators' subjective reports. These findings come from an intensive case study using nonlinear dimensionality reduction of functional neuroimaging data, analyzed with linear mixed models and correlations. The work highlights the need for further research on brain reorganization and health implications of both short-term and long-term ACAM-J practice.
Explore (New York, N.Y.)
January 1, 2024
Marjorie Woollacott, Justin Riddle, Niffe Hermansson et al.
5 citations
An intensive meditation practice called Fire Kasina can induce mystical experiences comparable to those produced by high-dose psychedelics. Six individuals completed a retreat and reported experiences they described as the most intense of their lives. Mean scores on the Revised Mystical Experience Questionnaire reached 85%, similar to prior observations with high-dose psilocybin and stronger than moderate-dose psilocybin. Scores on the Hood Mystical Experience Scale averaged 93%, exceeding levels reported for near-death experiences (74%) and high-dose psilocybin (77%). Participants also described substantial shifts in worldview following the retreat.
bioRxiv Preprint Server
September 6, 2025
Winson F.z. Yang, Akila Kadambi, Kilian Abellaneda-Pérez et al.
4 citations
preprint
An advanced meditative state called extended cessation (EC), where consciousness is voluntarily suspended and later resumes with heightened clarity and equanimity, provides a natural model for studying consciousness. Using ultra-high-resolution 7T fMRI with dense sampling of three individuals, the research mapped whole-brain activity, connectivity, gradients, and eigenmodes during EC, linking them to brain chemistry and cognitive maps. EC increased activity in sensory regions, reduced activity in higher-order association areas, subcortex, and brainstem, expanded the principal cortical gradient, and decreased low-order global eigenmodes.
Brain Imaging and Behavior
April 1, 2025
Jovan Jande, Isaac N Treves, Samantha L Ely et al.
4 citations
A systematic narrative review of neuroimaging studies on mindfulness-based interventions in youth (ages 5–18) found that such interventions may alter brain connectivity and activity. Analyzing 13 studies with 467 participants, most used a pre-post design with resting-state fMRI. Consistent patterns included increased functional connectivity within and between the salience, frontoparietal, and default mode networks, enhancements in white matter microstructure, and decreased default mode network activation with heightened salience network reactivity during mindfulness practice. These changes may support self-regulation and cognitive control, but methodological variability and small sample sizes limit generalizability.
bioRxiv (Cold Spring Harbor Laboratory)
Ruby M. Potash, Sean D. Van Mil, Mar Estarellas et al.
4 citations
preprint
During a deep meditative state called jhana, the brain's non-oscillatory, nonlinear neural activity—rather than oscillatory synchrony—best distinguishes the state from ordinary waking consciousness. In a single highly experienced meditator (over 20,000 hours of practice) studied across 29 sessions, EEG recordings showed that combining subjective ratings of attention with a nonlinear connectivity metric improved the ability to decode the meditative state compared to using neural measures alone. Deeper jhana states were marked by a balance between feedback and feedforward neural processes, indicating an equalization of internally and externally directed information processing. These findings suggest that refined conscious states involve distinct large-scale neural dynamics not captured by traditional oscillatory measures.
Mindfulness (N Y)
September 26, 2025
Saampras Ganesan, Nicholas T. van Dam, Sunjeev K. Kamboj et al.
3 citations
A 7-Tesla MRI study found that neurofeedback training (NFT) helps people become more aware of their mental states and boosts emotional well-being during real-world meditation. Participants who received NFT showed improved self-awareness and greater emotional benefits from meditation compared to those who did not receive NFT. The results suggest that NFT can enhance the positive effects of meditation practice.
bioRxiv Preprint Server
September 19, 2025
Kenneth Shinozuka, Winson F.z. Yang, Ruby M. Potash et al.
3 citations
preprint
Advanced meditators can enter a state called extended cessation (EC) in which they intentionally suppress consciousness and later emerge with clarity and equanimity. In the first electrophysiological study of EC, five meditators were recorded with EEG and MEG. EC markedly reduced alpha power and tended to increase neural complexity, unlike sleep, anesthesia, or disorders of consciousness. The findings indicate that the neural correlates of EC are distinct from other unconscious states and that complexity alone is not sufficient for consciousness, offering new insights into advanced meditation and human flourishing.
bioRxiv (Cold Spring Harbor Laboratory)
October 26, 2024
Saampras Ganesan, Nicholas T. van Dam, Sunjeev K. Kamboj et al.
3 citations
preprint
Personalized high-precision neurofeedback (NF) can help novice meditators better disengage from mental activity during meditation, improving emotional well-being and mindful awareness. In a single-blind, controlled study, 40 novices received two days of meditation training with feedback from either their own or a matched participant's posterior cingulate cortex (PCC) activity, measured using 7 Tesla fMRI. The experimental group showed stronger functional decoupling of PCC from dorsolateral prefrontal cortex, indicating improved control over disengagement. This led to greater improvements in emotional well-being and mindful awareness during a week of real-world self-guided meditation, supporting the utility of NF-guided meditation training.
Neuroscience and Biobehavioral Reviews
March 1, 2026
Hagar Tal, Malcolm Wright, Shawn Prest et al.
2 citations
Computational models of advanced meditation, particularly those using Active Inference, increasingly point to precision weighting—the confidence assigned to different model parameters—as a shared mechanism that shapes shifts in experience. Early models emphasize top-down attentional modulation toward interoception or specific objects, while later models focus on layer-specific precision re-weighting within the meditator's hierarchical generative model to target more specific phenomenology. Despite progress, minimal phenomenal experiences such as nonduality and cessations remain largely unaddressed. Few models account for increased cognitive flexibility or learning from meditation, and mechanisms behind informal practice, affective processes, and compassion traditions are underexplored.
Progress in Neuro-psychopharmacology and Biological Psychiatry
February 27, 2026
Chris H. Miller, Angela Hickman, Caitlin Baten et al.
2 citations
Ketamine, originally developed as an anesthetic, has emerged as a novel treatment for major depressive disorder (MDD) and treatment-resistant depression (TRD). Its antidepressant properties were discovered serendipitously, leading to FDA approval for TRD and MDD with suicidal ideation. The drug acts primarily as an NMDA receptor antagonist, triggering a paradoxical AMPA-mediated glutamate surge that promotes synaptogenesis and neuroplasticity. Intravenous ketamine and intranasal esketamine differ in dosing, bioavailability, and onset. Common adverse effects include dissociation, sedation, and hypertension. Efficacy studies show mixed-to-positive results, with non-inferiority to established treatments like electroconvulsive therapy. Future research aims to develop predictive markers for personalized medicine.
Neuroscience and Biobehavioral Reviews
February 1, 2026
Jonathan M. Lieberman, Matthew D. Sacchet
2 citations
Advanced meditation, cultivated through long-term expertise, provides a unique experimental window into the core mechanisms of consciousness. Two classes of meditative phenomena are highlighted: advanced concentrative absorption (related to jhāna), where highly abstract awareness persists while typical features of consciousness fade, and meditative endpoints (related to nirodha), involving a temporary suspension of consciousness. These states serve as precise, replicable anchors for a minimal model framework that aims to identify the simplest possible form of conscious experience. Integrating advanced meditation into neuroscience offers a promising path toward isolating the neural mechanisms supporting consciousness in its most reduced and fundamental forms.
Neuroimage
November 19, 2025
Sebastian Ehmann, Idil Sezer, Arielle S Keller et al.
2 citations
Attention regulation is a core mechanism of mindfulness meditation. Long-term meditation enhances trait-level improvements in executive attention, sustained attention, orienting, and reduces the attentional blink. Preliminary evidence also shows improvements in response inhibition, alertness, and less mind-wandering. Alertness benefits most from long-term and intensive practice. Attention-based techniques outperform non-attention-based ones, while observe-and-release techniques aid orienting and detection of closely spaced stimuli. These findings suggest that meditation enhances attention according to training specificity, but meditative development is non-linear and multidimensional, requiring balanced cultivation of multiple faculties. Methodological limitations, such as heterogeneous designs and insufficient state-trait differentiation, complicate interpretations.
October 16, 2025
Sebastian Ehmann, Terje Sparby, Daniel M. Ingram et al.
2 citations
preprint
The analogy that meditation is like mental training is widely used but conceptually underdeveloped. This paper bridges that gap by introducing principles from exercise science—such as programming, periodization, and core training variables (volume, frequency, duration, density, intensity)—to contemplative training contexts. It proposes defining training intensity as the graded phenomenal presence of specific meditative qualities alongside minimization of counteractive qualities, referenced against a normative standard. Advanced meditation involves not just accumulating training volume but refining skills to access advanced states, stages, and endpoints. The authors argue that adopting a unified semantic framework and systematically assessing these variables would enable more precise, comparable, and cumulative analyses across studies.
February 6, 2025
Rosalind McAlpine, Merve Utanğaç, Joanna Kuć et al.
2 citations
preprint
Experienced meditators who also use psychedelics expect meditation to enhance acceptance and present-moment focus during psychedelic sessions, while increasing feelings of oceanic boundlessness and reducing anxious ego-dissolution. Among those with limited meditation experience (1-3 years) and few psychedelic sessions (1-20), adhering to a specific meditation tradition was linked to higher perceived benefits of meditation for psychedelic preparation. However, for highly experienced meditators (10+ years) with limited psychedelic use, non-adherents reported higher perceived benefits. Loving-Kindness Meditation was rated the most beneficial preparatory practice. Participants recommended about three weeks of daily 30-minute sessions, favoring online and asynchronous delivery.
Frontiers in Psychiatry
January 1, 2025
Kaveh Rayani, Andrea Grabovac, Peter Chan et al.
2 citations
In a pilot trial, 31 adults with PTSD received either real or sham repetitive transcranial magnetic stimulation (rTMS) over the right dorsolateral prefrontal cortex. Mindfulness scores, measured by the Five Facet Mindfulness Questionnaire, did not improve significantly immediately after treatment when corrected for multiple comparisons. However, by three months after treatment, those who received real rTMS showed significant gains in total mindfulness and nonreactivity. The delayed improvement suggests the benefits of rTMS on dispositional mindfulness may take time to emerge. The findings indicate that brain stimulation might eventually help reduce PTSD-related suffering by boosting mindfulness.
October 28, 2024
Sebastian Ehmann, Idil Sezer, Isaac N Treves et al.
2 citations
preprint
Long-term meditators show a distinct pattern of cognitive and brain changes, including enhanced integration of sensory and cognitive processes, reduced emotional reactivity, more rational decision-making, and altered self-awareness. Neuroimaging reveals increased activity in brain networks related to interoception and pain, along with reduced connectivity between executive and salience networks, decreased amygdala response to fear, and changes in default-mode network activity linked to emotional neutrality and non-ordinary states of consciousness. Methodological limitations, such as varied meditation practices among participants, prevent clear conclusions about specific cognitive changes over time. A unified research framework is needed to systematically study advanced meditation's unfolding stages and endpoints.
April 8, 2024
Saampras Ganesan, Aki Tsuchiyagaito, Greg J Siegle et al.
2 citations
preprint
Meditation practices, which have been adapted into manualized interventions for conditions like depression, pain, addiction, and anxiety, show therapeutic promise, but their neuroscientific basis remains unclear. Current neuroimaging studies rely on small, heterogeneous datasets that vary in practice types, participant experience, clinical targets, and imaging methods, limiting generalizability and replicability. To address this, the ENIGMA-Meditation consortium was formed as a global collaboration to conduct systematic meta- and mega-analyses of distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and rigorously characterize the neural mechanisms underlying meditation's effects on psychological and cognitive attributes, advancing the field of contemplative neuroscience.
May 29, 2019
Michael Lifshitz, Matthew D. Sacchet, Julia M. Huntenburg et al.
1 citation
Major depressive disorder involves abnormal communication between large-scale brain networks. A randomized, active-controlled trial tested whether mindfulness-based therapy could alter resting-state functional connectivity in clinically depressed patients. A brief, clinically effective mindfulness intervention functionally decoupled top-down control regions from brain areas involved in sensory, affective, and attentional processing. These findings identify specific neural targets of mindfulness training, offering new insight into how this therapeutic approach works.