Inferring jhana-type advanced concentration absorption meditation (ACAM-J) states from fMRI data is challenging due to the spatially distributed nature of meditation-related effects, substantial inter-individual variability that can exceed within-subject state differences, and limited sample sizes. Conventional machine-learning approaches often formulate this problem as unimodal, Euclidean,...
October 21, 2026Joshua Cain, Micah Alan Johnson, Amirvala Tavakoli et al.
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Sustained contemplative practice confers well-documented psychological and physiological benefits, yet the experiential deepening that motivates practitioners can require many hours of practice, and mastery is not assured. Methods that accelerate training would broaden access to these benefits and could also test mechanism: the posterior cingulate cortex (PCC), caudate, and anterior insula are...
October 20, 2026Fedal Saini, Hagar Tal, Ruben Laukkonen et al.
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First-person reports reveal a surprising convergence between symptoms of depersonalisation disorder (DPD) and certain forms of advanced meditation (AM). In both, individuals describe a fading, and even disappearance, of the ordinarily stable sense of being an embodied self. Yet the experiential tone and functional consequences strikingly differ. In DPD this alteration is endured as distressing...
Meditation research is increasingly moving beyond mindfulness and other early-stage practices toward advanced meditation, encompassing states, stages, and endpoints that progressively unfold with increasing expertise through meditative development. This emerging subfield consists of interdisciplinary research that brings advanced meditation within reach of systematic scientific investigation....
Meditation research has grown considerably, yet its clinical implications for advanced and long-term practitioners remain poorly understood. Meditation’s mental health implications extend beyond benefit, encompassing psychiatric risk, adverse experiences, and differentiating between meditative progress and psychopathology. This review synthesizes evidence on how advanced and long-term...
Abstract Objectives Emerging research suggests that meditation may support more beneficial psychedelic experiences while reducing the likelihood of lasting negative effects, yet its specific preparatory benefits remain underexplored. This study aimed to investigate the perceived utility of meditation as a preparatory tool for enhancing positive outcomes and reducing negative effects during...
Consciousness can persist, transform, and dissolve across wakefulness, sleep, and advanced meditation. Despite empirical and theoretical advances within each domain, these states are rarely examined within an integrated scientific framework. An interdisciplinary perspective reveals converging phenomena that challenge binary accounts of consciousness and highlight its graded, dynamic, and...
Advanced meditation includes meditative endpoints that are outcomes of meditation practice and occur with time and mastery of meditation. The “cessation” event (c.f. nirodha in Theravada Buddhism) is a meditative endpoint characterized by a loss of consciousness followed by a sense of mental reset and deep clarity. In general, organization of brain activity exists along a “criticality”...
The study of meditation has grown considerably in academic research, including robust findings demonstrating its positive impact on several domains of psychological well-being. Functional magnetic resonance imaging (fMRI) studies have provided evidence for neural correlates underlying these effects; however, there has not yet been a comprehensive whole-brain meta-analytic synthesis across...
This article proposes a definition of advanced meditation which in concise form is the states, stages, and endpoints that arise with the maturation and mastery of awareness skills. Advanced meditation involves experiential and structural mental changes, sometimes radical, to volition, affect, cognition, and self-related processing in the direction of effortlessness, intentional control,...
Despite rapidly growing interest in meditation, research has disproportionately emphasized short-term outcomes in novices and mindfulness-based practices, leaving advanced and long-term meditation largely unexplored. This review examines how sustained and skill-developed meditation practices positively shape well-being, interpersonal relationships, and emotion regulation. Following PRISMA...
While meditation has been increasingly associated with challenging and adverse experiences, especially in more advanced and high-density practices, little is known about how advanced practitioners experience, make sense of, and integrate non-ordinary experiences that may disrupt their sense of self, reality, embodiment, and meaning. Building on recent advances in the scientific study of...
Abstract Understanding how the sense of self can be attenuated or reconfigured without loss of consciousness remains a central challenge in contemporary consciousness science. We propose a multidimensional framework of graded self-attenuation, in which the self is conceptualized as a dynamic configuration of distributed neural processes. Within this framework, contemplative practice attenuates...
How should we understand the radical changes in bodily awareness that occur during advanced meditation? Existing approaches subsume these changes under frameworks of self-dissolution or operationalize them through interoceptive measures that assume ongoing bodily sensation. This paper argues for bracketing the self when studying bodily awareness in advanced concentrative absorption meditation...
May 20, 2026Chuong Ngo, Lionel A Newman, Monika Stasytyte et al.
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Advanced meditative absorption states remain difficult to study scientifically because they are rare, challenging to elicit under controlled conditions, and depend strongly on first-person phenomenology. This study presents a neurophenomenological case report of an advanced Yogic meditator with more than 20 years of sustained practice who reliably entered a deeply absorbed state referred to by...
Third wave meditation research-the study of advanced meditation-investigates states, stages, and endpoints of meditation practice that emerge with increasing mastery. We review current neuroscientific progress, outline future research directions, and highlight far-reaching implications of this emerging scientific subfield.
Consciousness can persist, transform, and dissolve across wakefulness, sleep, and advanced meditation. Despite empirical and theoretical advances within each domain, these states are rarely examined within an integrated scientific framework. An interdisciplinary perspective reveals converging phenomena that challenge binary accounts of consciousness and highlight its graded, dynamic, and...
Psychedelic-assisted therapy shows promise for treating various mental health conditions; however, its reliance on intensive psychological preparation limits its broader application. Digital health interventions have the potential to address this limitation by providing structured, accessible and scalable preparation solutions. This randomised controlled feasibility trial aims to evaluate the...
Meditation research is increasingly moving beyond the study of health-related benefits toward the investigation of non-ordinary states of consciousness and ways of being that may arise through advanced meditative practice. Alongside potential benefits, however, intensive or advanced meditation has been associated with a higher incidence of meditation-related psychological adverse effects,...
This paper presents the Insight Development Process (IDP), a theoretical framework of propositional insight development to facilitate its scientific investigation. This framework formulates three empirically-testable propositions: transience, self-lessness, and incongruence, each defined as a perceptual mode that individuals report during advanced insight meditation. These propositions parallel...
Computational phenomenology has emerged as a powerful framework for investigating advanced meditation states and stages, and meditative development and endpoints. Various models have been proposed to mechanistically explain the diverse experiences associated with these practices, including enhanced well-being, shifts in attentional control, the loosening or 'defabrication' of perceptual...
Ketamine pharmacotherapy provides a novel treatment option for major depressive disorder (MDD) and has generated a large, growing body of research regarding its biochemical and clinical properties. This narrative review summarizes the history of ketamine's development, beginning as a general anesthetic, continuing with a discovery of its antidepressant properties, and leading up to its landmark...
arXiv.orgFebruary 13, 2026Puneet Kumar, W. F. Yang, Alakhsimar Singh et al.
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Jhana advanced concentration absorption meditation (ACAM-J) is related to profound changes in consciousness and cognitive processing, making the study of their neural correlates vital for insights into consciousness and well-being. This study evaluates whether functional MRI-derived regional homogeneity (ReHo) can be used to classify ACAM-J using machine-learning approaches. We collected...
Introduction: Jhana advanced concentrative absorption meditation (ACAM-J) involves profound changes in consciousness, making its neural correlates important for understanding consciousness and well-being. Prior neuroimaging has relied on univariate, group-level contrasts, leaving open whether ACAM-J carries distributed neural signatures decodable from individual scans. This study evaluates...
Extended cessation (EC) is a rare, non-ordinary meditative endpoint characterized by a temporary absence of reportable phenomenal experience, followed by an extraordinary perceptual vividness, openness, equanimity and affective balance. EC thus offers a unique, non-pharmacological window into the brain dynamics underlying suspension of conscious experience and the subsequent psychological...