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Matthew D. Sacchet

Harvard University, McLean Hospital

82 papers in the library · 1,334 citations · publishing 2012-2026

Papers

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Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability

Cerebral Cortex December 16, 2019 Danielle D. DeSouza, Katy H. Stimpson, Laima Baltusis et al. 26 citations

Hypnosis is the oldest form of Western psychotherapy and a powerful evidence-based treatment for numerous disorders. Hypnotizability is variable between individuals; however, it is a stable trait throughout adulthood, suggesting that neurophysiological factors may underlie hypnotic responsiveness. One brain region of particular interest in functional neuroimaging studies of hypnotizability is...

Mindfulness-based therapy regulates brain connectivity in major depression

May 29, 2019 Michael Lifshitz, Matthew D. Sacchet, Julia M. Huntenburg et al. 1 citation

Major depressive disorder (MDD) is associated with abnormal functional interactions among large-scale brain networks. Here we report findings from a randomized, active-controlled trial examining whether mindfulness-based therapy can regulate specific patterns of resting-state functional connectivity in clinically depressed patients. We show that a brief, clinically effective mindfulness...

Source-space EEG neurofeedback links subjective experience with brain activity during effortless awareness meditation

Neuroimage February 26, 2016 R. Lutterveld, Sean Dae Houlihan, Prasanta Pal et al.

Background: Meditation is increasingly showing beneficial effects for psychiatric disorders. However, learning to meditate is not straightforward as there are no easily discernible outward signs of performance and thus no direct feedback is possible. As meditation has been found to correlate with posterior cingulate cortex (PCC) activity, we tested whether source‐space EEG neurofeedback from...

Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation

Frontiers in Human Neuroscience 2013 Catherine E. Kerr, Matthew D. Sacchet, Sara W. Lazar et al. 329 citations

Using a common set of mindfulness exercises, mindfulness based stress reduction (MBSR) and mindfulness based cognitive therapy (MBCT) have been shown to reduce distress in chronic pain and decrease risk of depression relapse. These standardized mindfulness (ST-Mindfulness) practices predominantly require attending to breath and body sensations. Here, we offer a novel view of ST-Mindfulness's...

Mindfulness training alters emotional memory recall compared to active controls: support for an emotional information processing model of mindfulness.

Frontiers in Human Neuroscience 2012 Douglas Roberts-Wolfe, Matthew D. Sacchet, Elizabeth Hastings et al. 79 citations

While mindfulness-based interventions have received widespread application in both clinical and non-clinical populations, the mechanism by which mindfulness meditation improves well-being remains elusive. One possibility is that mindfulness training alters the processing of emotional information, similar to prevailing cognitive models of depression and anxiety. The aim of this study was to...

The computational unconscious: Adaptive narrative control, psychopathology, and subjective well-being

George Deane, Jonas Mago, Aikaterini Fotopoulou et al. 7 citations preprint

This paper introduces the notion of adaptive narrative control, a conception of how subpersonal computational processes shape the contents of conscious experience to realize adaptive behavior. We unpack the implications of the theory for understanding the computational mechanisms underwriting psychopathology and improvements in subjective well-being associated with psychedelic therapy and...

Adult development, meditation, wisdom, and unlearning: Toward a science of advanced meditation

Tom Murray, Thomas McConkie, Matthew D. Sacchet preprint

Contemplative science is entering a “third wave” that investigates advanced meditative development, including the study of advanced states and practitioners and the phenomenology and neurocognitive correlates of enduring trait transformations (meditative development). This paper argues that these research directions would benefit from the systematic inclusion of adult cognitive-developmental...