PLoS Medicine
April 1, 2026
Yifan Li, Vivien Kin Yi Chan, Mark Jit et al.
Treatment-resistant depression (TRD), defined as failure to respond to at least two adequately administered antidepressant (AD) regimens, imposes major clinical and economic burdens. Esketamine nasal spray offers rapid antidepressant clinical effects, yet previous evaluations compared it only with unrealistic comparators such as AD monotherapy. This study assessed the cost-effectiveness of...
PLoS Medicine
December 1, 2025
Daniel T. Myran, Rachael MacDonald-Spracklin, Michael Pugliese et al.
Hallucinogen use for both recreational and medical purposes is rapidly increasing globally, raising concerns about potential adverse effects. This study examined the risk of incident mania or bipolar disorder (BD) diagnosis associated with having an emergency department (ED) visit or hospitalization involving hallucinogens. We used a population-based cohort study of all individuals aged 14-65...
PLoS Medicine
September 19, 2025
Benjamin R. Lewis, John Hendrick, Kevin Byrne et al.
5 citations
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...
PLoS Medicine
January 11, 2021
Julieta Galante, Claire Friedrich, Anna F. Dawson et al.
Background: There is an urgent need for mental health promotion in nonclinical settings. Mindfulness-based programmes (MBPs) are being widely implemented to reduce stress, but a comprehensive evidence synthesis is lacking. We reviewed trials to assess whether MBPs promote mental health relative to no intervention or comparator interventions. Methods and findings: Following a detailed...
PLoS Medicine
September 28, 2009
Louisa Degenhardt, Wayne Hall, Michael T. Lynskey et al.
48 citations
N Comparative risk assessments estimate the proportion of a disease that can be attributed to a particular risk exposure and are important guides for health planning.N In observational studies, there has been consistent evidence that cannabis use is associated with an increased risk of schizophrenia and more generally, psychosis.N There is debate about whether such observational evidence is...