CNS Drugs
August 7, 2026
Chiranth Bhagavan, O. Carter, Glenn Nielsen et al.
BACKGROUND: Psychedelics exert widespread effects on brain activity, but their impact on motor function is unclear. This is clinically relevant given the emerging interest in psychedelic-assisted physical therapy for disorders of motor function. This study examined the feasibility and safety of administering movement tasks following low-to-moderate doses of psilocybin in healthy volunteers....
Psychopharmacology
June 17, 2026
Pierre Klintefors, Chiranth Bhagavan, Richard Kanaan et al.
RATIONALE: Clinical interest in psilocybin-assisted rehabilitation for motor disorders is growing. However, psilocybin's motor effects are under-researched, and quantifying them is essential for assessing treatment risks and outcomes. OBJECTIVES: This study aims to clarify whether acute effects of psilocybin disrupt established patterns of manual dexterity and coordination. Specifically, we...
BMJ Open
May 11, 2026
Julia Colcott, Alexandre A. Guerin, Olivia Carter et al.
Despite growing interest in the therapeutic potential of 3,4-methylenedioxymethamphetamine (MDMA), no targeted measure to systematically assess side effects of MDMA-assisted psychotherapy (MDMA-AP) exists. Our aim was to develop an MDMA-Assisted Psychotherapy Side Effects Tool (M-SET) to capture side effects over the course of MDMA-AP. Informed by a systematic review and a review of other...
medRxiv Preprint Server
April 17, 2026
Chiranth Bhagavan, Orwa Dandash, Olivia Carter et al.
preprint
Background Psilocybin is a classic psychedelic that acutely alters brain functional connectivity. These changes are linked to therapeutic doses and subjective effects, with some evidence that changes persist beyond acute drug administration. However, the effects of lower doses on sustained connectivity changes remain unclear.
Progress in Neuro-psychopharmacology and Biological Psychiatry
February 10, 2026
Chiranth Bhagavan, Olivia Carter, Alexander Bryson et al.
1 citation
Functional disorders, characterised by symptoms unexplained by organic disease, impose a significant burden on individuals and healthcare systems. Existing treatments are limited in efficacy, with no effective pharmacotherapies. There is growing evidence supporting the treatment potential of psychedelics in neuropsychiatric conditions, including several distinct functional disorders. This...
medRxiv
December 23, 2025
Chiranth Bhagavan, Olivia Carter, Glenn Nielsen et al.
1 citation
Abstract Background Psychedelics exert widespread effects on brain activity, but their impact on motor function is unclear. This is clinically relevant given the emerging interest in psychedelic-assisted physical therapy for disorders of motor function. This study’s primary objectives examined the feasibility and safety of administering movement tasks following low-to-moderate doses of...
Acta Neuropsychiatrica
November 4, 2025
Chiranth Bhagavan, Alexander Bryson, Olivia Carter et al.
4 citations
Abstract Background: Motor functional neurological disorder (FND) is a common illness associated with significant functional impairment. There are no effective pharmacotherapies, and despite the early promise of physiotherapy studies, many suffer disabling symptoms in the long term. There is a theoretical rationale for combining psychedelics with physiotherapy; however, the potential benefit of...
September 30, 2025
Toby J. Woods, Andrew W. Corcoran, Olivia Carter et al.
preprint
The most well known study on doing nothing concluded that being alone for 15 mins with nothing to do but think is aversive. Here we examine skilful doing nothing in the form of Stillness Meditation. Meditation-naive adult participants (N = 165) were randomly allocated to 15 mins of Stillness Meditation or one of two active controls (Focused Attention and Audiobook). Stillness Meditation...
Therapeutic Advances in Psychopharmacology
September 1, 2025
Sally Meikle, Olivia Carter, Paul Liknaitzky et al.
2 citations
Background: Depressive disorders are a major global health challenge, with many individuals unresponsive to existing treatments. Novel psychedelic therapies show promise but require further research. Objectives: This study aimed to evaluate the feasibility, safety and effectiveness of psilocybin with psychotherapeutic support for treatment-resistant depression (TRD), investigate predictors of...
The International Journal of Neuropsychopharmacology
August 1, 2025
Susan Meikle, Olivia Carter, Paul Liknaitzky et al.
Abstract Background Depressive disorders are a major global health challenge, with many individuals unresponsive to existing treatments or left with residual symptoms such as impairments in cognition and social functioning. Emerging psychedelic therapies show promise for treating depression but require further research. Aims & Objectives This pilot study aimed to evaluate the feasibility,...
bioRxiv Preprint Server
July 16, 2025
Borjan Milinkovic, Anil K. Seth, Lionel Barnett et al.
2 citations
preprint
Conscious experience depends on the coordinated activity of neural processes that span multiple scales—from synapses to whole-brain dynamics. A recently introduced measure, dynamical independence, identifies, characterises and quantifies these multi-scale relationships using an information-theoretic dimensionality-reduction approach. Here, we use DI to examine changes in emergent dynamical...
Psychology of Consciousness Theory Research and Practice
June 12, 2025
Etzel Cardeña, Aviva Berkovich-Ohana, Katja Valli et al.
11 citations
This article presents a taxonomy of altered states of consciousness, primarily based on their central phenomenological features. Following taxonomic principles and a modified Delphi methodology, a multidisciplinary, international group identified eight distinct phenomenological/behavioral states (some with subcategories): proto and transitional, delirium, minimal to no awareness, experiential...
Psychiatric Research and Clinical Practice
July 23, 2024
Chiranth Bhagavan, Richard Kanaan, Olivia Carter et al.
2 citations
Background There has been a resurgence of research into the potential therapeutic benefits of psychedelics for neuropsychiatric disorders. Classic psychedelics, such as psilocybin, exert complex effects on higher cognitive functions such as perception and awareness, but their impact on motor function remains unexplored. Moreover, there is a theoretical rationale for using psychedelics to...
Neuropsychopharmacology
April 23, 2024
Julia Colcott, Olivia Carter, Sally Meikle et al.
37 citations
Abstract Evidence suggests that MDMA-assisted psychotherapy (MDMA-AP) has therapeutic potential for treatment of psychiatric illness. We conducted the first comprehensive systematic review and meta-analysis of the side effects of MDMA-AP across indications. We also assessed the quality of side effects-reporting in published trials of MDMA-AP. PubMed, EMBASE, PsycINFO, MEDLINE and Cochrane...
Mindfulness
June 1, 2023
Toby J. Woods, Jennifer Windt, Lydia Brown et al.
15 citations
Abstract Objectives Contentless experience involves an absence of mental content such as thoughts and perceptions. It is often described as pure consciousness or complete stillness/silence, and is a goal in Shamatha, Thai Forest, and Stillness Meditation. This study examined the subjective character of the deepest experience of stillness/silence typically reported in each practice, and whether...
Phenomenology and the Cognitive Sciences
June 2, 2022
Toby J. Woods, Jennifer Windt, Olivia Carter
13 citations
Abstract In contentless experience (sometimes termed pure consciousness ) there is an absence of mental content such as thought, perception, and mental imagery. The path to contentless experience in meditation can be taken to comprise the meditation technique, and the experiences (“interim-states”) on the way to the contentless “goal-state/s”. Shamatha, Transcendental, and Stillness Meditation...
Phenomenology and the Cognitive Sciences
May 24, 2022
Toby J. Woods, Jennifer Windt, Olivia Carter
17 citations
Abstract Contentless experience involves an absence of mental content such as thought, perception, and mental imagery. In academic work it has been classically treated as including states like those aimed for in Shamatha, Transcendental, and Stillness Meditation. We have used evidence synthesis to select and review 135 expert texts from within the three traditions. In this paper we identify the...
Australian & New Zealand Journal of Psychiatry
March 21, 2021
Daniel Perkins, Jerome Sarris, Susan L. Rossell et al.
53 citations
The medical use of psychedelic substances (e.g. psilocybin, ayahuasca, lysergic acid diethylamide and 3,4-methylenedioxymethamphetamine) is attracting renewed interest, driven by a pressing need for research and development of novel therapies for psychiatric disorders, as well as promising results of contemporary studies. In this Viewpoint, we reflect upon the ‘Clinical Memorandum on...
Schizophrenia Bulletin
December 7, 2020
Ilvana Dzafic, Kit Melissa Larsen, Hayley Darke et al.
26 citations
Recent theories in computational psychiatry propose that unusual perceptual experiences and delusional beliefs may emerge as a consequence of aberrant inference and disruptions in sensory learning. The current study investigates these theories and examines the alterations that are specific to schizophrenia spectrum disorders vs those that occur as psychotic phenomena intensify, regardless of...
Frontiers in Psychology
July 8, 2020
Toby J. Woods, Jennifer Windt, Olivia Carter
25 citations
Shamatha, Transcendental, and Stillness Meditation are said to aim for "contentless" experiences, where mental content such as thoughts, perceptions, and mental images is absent. Silence is understood to be a central feature of those experiences. The main source of information about the experiences is texts by experts from within the three traditions. Previous research has tended not to use an...
The Journal of Comparative Neurology
May 3, 2020
Olivia Carter, Bruno van Swinderen, David A. Leopold et al.
29 citations
Abstract This review in memoriam of Jack Pettigrew provides an overview of past and current research into the phenomenon of multistable perception across multiple animal species. Multistable perception is characterized by two or more perceptual interpretations spontaneously alternating, or rivaling, when animals are exposed to stimuli with inherent sensory ambiguity. There is a wide array of...
Science
January 25, 2018
Olivia Carter, Jakob Hohwy, Jeroen J A Van Boxtel et al.
86 citations
In their Review “What is consciousness, and could machines have it?” (27 October 2017, p. [486][1]), S. Dehaene et al. argue that the science of consciousness indicates that we are not on the verge of creating conscious machines. However, Dehaene et al. ask and answer the wrong questions. To
Neuroscience of Consciousness
2018
Tim Bayne, Olivia Carter
153 citations
It has often been suggested in the popular and academic literature that the psychedelic state qualifies as a higher state of consciousness relative to the state of normal waking awareness. This article subjects this proposal to critical scrutiny, focusing on the question of what it would mean for a state of consciousness to be 'higher'. We begin by considering the contrast between conscious...
Journal of Research in Personality
March 21, 2017
Anna Antinori, Olivia Carter, Luke D. Smillie
112 citations
Openness to experience is characterised by flexible and inclusive cognition. Here we investigated whether this extends to basic visual perception, such that open people combine information more flexibly, even at low-levels of perceptual processing. We used binocular rivalry, where the brain alternates between perceptual solutions and times where neither solution is fully suppressed, mixed...
The International Journal of Neuropsychopharmacology
February 8, 2017
Alexander Bryson, Olivia Carter, Trevor R. Norman et al.
19 citations
Functional neurological disorders are frequently encountered in clinical practice. They have a poor prognosis and treatment options are limited. Their etiology is unknown, but leading theories propose a disturbance of somatic self-representation: the mind perceives dysfunction of a body region despite intact motor and sensory pathways. Central to this model is the concept of an abnormal...