Psychiatric Research and Clinical Practice
July 2, 2026
Kush V. Bhatt, Tara Austin, Danny Alam et al.
Objective This study evaluated whether intramuscular (IM) ketamine is non‐inferior to intranasal (IN) esketamine for treatment‐resistant depression (TRD) and assessed differences in safety and healthcare costs. Methods In a retrospective, observational sequential cohort at the VA San Diego, 179 Veterans with TRD received eight treatments of either IN esketamine ( n = 89) or IM ketamine ( n =...
Psychiatric Research and Clinical Practice
March 3, 2026
Ricarda Evens
In psychiatry, the term flashback is widely recognized in relation to post-traumatic stress disorder (PTSD) as well as in the characterization of post-psychedelic experiences. Although it is now most commonly associated with PTSD, the term was originally introduced in the context of psychedelics. While it broadly denotes specific forms of re-experiencing in both fields, its precise meaning...
Psychiatric Research and Clinical Practice
January 14, 2026
Celia Faye Jacobsen, Dea Siggaard Stenbæk, Stig Poulsen et al.
3 citations
A key distinction among clinical trials on psilocybin treatments, for example, those targeting depression, has been whether the psilocybin dosing session is combined with bona fide psychotherapy or with what is referred to as “psychological support” (1-3). The most developed model of psychological support is the Compass Psychological Support Model (CPSM; 1). Kirlić and colleagues specifically...
Psychiatric Research and Clinical Practice
February 11, 2025
Jules Evans, Marc Aixalà, Brian T Anderson et al.
18 citations
Objective: This article outlines recommendations from 30 psychedelic researchers on how to create a better psychedelic safety net. Methods: A survey of 30 psychedelic researchers asked them to identify key critical research gaps around psychedelic harm and safety. Results: The critical research gaps identified by the authors included defining the main types of psychedelic harm, the predictors...
Psychiatric Research and Clinical Practice
July 23, 2024
Chiranth Bhagavan, Richard Kanaan, Olivia Carter et al.
2 citations
Background There has been a resurgence of research into the potential therapeutic benefits of psychedelics for neuropsychiatric disorders. Classic psychedelics, such as psilocybin, exert complex effects on higher cognitive functions such as perception and awareness, but their impact on motor function remains unexplored. Moreover, there is a theoretical rationale for using psychedelics to...
Psychiatric Research and Clinical Practice
November 10, 2020
J. Allan Hobson, Jarrod Gott, Karl Friston
29 citations
OBJECTIVE: -that emerges from sleep research and theoretical neurobiology-can be applied to pathophysiology and psychopathology in psychiatry. METHODS: Our starting point is that the mind and brain are emergent aspects of the same (neuronal) dynamics; namely, the brain-mind. Our endpoint is that synaptic dysconnection syndromes inherit the same dual aspect; namely, aberrant inference or belief...
Psychiatric Research and Clinical Practice
October 1, 2019
Lori L. Davis, Charles Whetsell, Mark B Hamner et al.
Posttraumatic stress disorder (PTSD) is often difficult to treat, and many patients do not achieve full remission. Complementary and integrative health approaches, such as mindfulness meditation, are intended to be integrated with evidence-based treatment. This study examined the efficacy of mindfulness-based stress reduction (MBSR) in the treatment of PTSD in U.S. military veterans. Veterans...