bioRxiv Preprint Server
June 7, 2026
Andrea I. Luppi, Dragana Manasova, Justine Y. Hansen et al.
preprint
Consciousness and cognition arise from the ongoing interactions between brain regions. Synchronous fluctuations of fMRI signals may indicate that two brain regions perform similar cognitive functions, but neural interactions are also constrained by anatomical connectivity and regions’ molecular, cytoarchitectonic, and metabolic profiles. Here we disentangle the respective contributions of...
The International journal of clinical and experimental hypnosis
May 27, 2026
Amélie Johnson, Clara Bourgy, Marine Dupuis et al.
Hypnosis is increasingly used in clinical contexts to improve pain management and is supported by experimental research, showing reduced pain perception to controlled nociceptive stimuli. This study investigated spatial selectivity of focused hypnotic analgesia (FHA), a technique used to reduce pain in one restricted body part. Series of brief contact heat stimuli were applied randomly to the...
arXiv (Cornell University)
September 23, 2025
Victor Oswald, Karim Jerbi, Corine Sombrun et al.
Non-ordinary states of consciousness (NOC) provide an opportunity to experience highly intense, unique, and perceptually rich subjective states. The neural mechanisms supporting these experiences remain poorly understood. This study examined brain activity associated with a self-induced, substance-free NOC known as Auto-Induced Cognitive Trance (AICT). Twenty-seven trained participants...
British Journal of Anaesthesia
April 1, 2025
Milan Van Maldegem, Jakub Vohryzek, Selen Atasoy et al.
3 citations
Ketamine, in doses suitable to induce anaesthesia in humans, gives rise to a unique state of unresponsiveness accompanied by vivid experiences and sensations, making it possible to disentangle the correlated but distinct concepts of conscious awareness and behavioural responsiveness. This distinction is often overlooked in the study of consciousness. The mathematical framework of connectome...
OBM Integrative and Complementary Medicine
March 5, 2025
Gaëtan Collignon, Aminata Bicego, Marie-Elisabeth Faymonville et al.
2 citations
Auto-induced cognitive trance (AICT) is a method for voluntarily entering modified state of consciousness. The therapeutic implications of AICT are still unknown. Since complementary approaches based on modified states of consciousness are recognized to be beneficial for patients suffering from chronic pain (e.g., hypnosis, meditation), we here present the first case report of a 68-year-old man...
Int J Clin Health Psychol
2025
Victor Oswald, Karim Jerbi, Corine Sombrun et al.
4 citations
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system.
The International journal of clinical and experimental hypnosis
2025
Aminata Bicego, Naji Alnagger, Etzel Cardeña et al.
1 citation
Mystical-type experiences can be induced through techniques like hypnosis and meditation. These experiences are common in near-death experiences (NDEs) and have been linked to paranormal beliefs. This study explored auto-induced cognitive trance (AICT) as a method to induce mystical-type experiences and NDE outside of life threatening situations (NDE-like), as well as examining the influence of...
BMC Complementary Medicine and Therapies
November 4, 2024
Nolwenn Marie, Yannick Lafon, Aminata Bicego et al.
13 citations
Shamanism is a spiritual tradition in which trance practitioners deliberately modify their state of consciousness to seemingly interact with an invisible world to resolve their community members' problems. This review aims to provide a multidisciplinary overview of scientific research on shamanic trance. The search was performed using PubMed and Google Scholar databases. Twenty-seven articles...
bioRxiv (Cold Spring Harbor Laboratory)
June 25, 2024
Milan Van Maldegem, Jakub Vohryzek, Selen Atasoy et al.
2 citations
preprint
Abstract Ketamine is classified as a dissociative anaesthetic that, in sub-anaesthetic doses, can produce an altered state of consciousness characterised by dissociative symptoms, visual and auditory hallucinations, and perceptual distortions. Given the anaesthetic-like and psychedelic-like nature of this compound, it is expected to have different effects on brain dynamics in anaesthetic doses...
Neuroimage
June 1, 2024
Pradeep Kumar, Rajanikant Panda, Kanishka Sharma et al.
20 citations
High-order interactions are required across brain regions to accomplish specific cognitive functions. These functional interdependencies are reflected by synergistic information that can be obtained by combining the information from all the sources considered and redundant information (i.e., common information provided by all the sources). However, electroencephalogram (EEG) functional...
Current Opinion in Behavioral Sciences
May 9, 2024
Olivia Gosseries, Nolwenn Marie, Yannick Lafon et al.
16 citations
This review provides an exploration of trance states, covering their phenomenology, neural mechanisms, and clinical uses. Trance states, present in diverse cultural contexts from shamanic practices to modern adaptations, have recently captured the interest of researchers and clinicians. Here, we delve into the phenomenological aspects of trance experiences, highlighting the most common...
Neuroscience of Consciousness
2024
Charlotte Grégoire, Corine Sombrun, Philippe Lenaif et al.
10 citations
Trance states include various practices characterized by a modulation of consciousness, but with their own specific characteristics and induction techniques. They have been very seldom scientifically studied, and their phenomenological similarities and differences are poorly documented. This paper will focus on two types of Western trances developed after the leaders were trained in traditional...
The International journal of clinical and experimental hypnosis
2024
Mélanie Louras, Audrey Vanhaudenhuyse, Rajanikant Panda et al.
8 citations
When used separately, virtual reality (VR) and mind-body therapies (MBTs) have the potential to reduce pain across various acute and chronic conditions. While their combination is increasingly used, no study offers a consolidated presentation of VR and MBTs. This study aims to propose an overview of the effectiveness of VR combined with MBTs (i.e., meditation, mindfulness, relaxation, and...
Neuroscience of Consciousness
2024
Audrey Vanhaudenhuyse, Marie-Carmen Castillo, Charlotte Martial et al.
7 citations
Auto-induced cognitive trance (AICT) is a modified state of consciousness derived from shamanic tradition that can be practised by individuals after specific training. The aim of this work was to characterize the phenomenological experiences of AICT, using text mining analysis. Free recalls of subjective experiences were audio-recorded in 27 participants after five pseudo-randomized...
Scientific Reports
September 22, 2023
Victor Oswald, Audrey Vanhaudenhuyse, Jitka Annen et al.
24 citations
Self-induced cognitive trance (SICT) is a voluntary non-ordinary state of consciousness characterized by a lucid yet narrowed awareness of the external surroundings. It involves a hyper-focused immersive experience of flow, expanded inner imagery, modified somatosensory processing, and an altered perception of self and time. SICT is gaining attention due to its potential clinical applications....
Science Advances
June 14, 2023
Leor Roseman, Christopher Timmermann, Daniel Golkowski et al.
65 citations
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters...
Frontiers in Human Neuroscience
April 28, 2023
Aminata Bicego, Héléna Cassol, Jessica Simon et al.
13 citations
Introduction Little is known about the potential personality and psychological predictors of near-death experiences (NDEs), and fewer yet those of near-death-like experiences (NDEs-like; similar phenomenology reported after a non-life-threatening context). This study investigated whether personality traits (Openness, Extraversion, Pleasantness, Conscientiousness, and Neuroticism), dissociative...
Journal of Cognitive Neuroscience
2023
Rajanikant Panda, Audrey Vanhaudenhuyse, Andrea Piarulli et al.
15 citations
Hypnosis has been shown to be of clinical utility; however, its underlying neural mechanisms remain unclear. This study aims to investigate altered brain dynamics during the non-ordinary state of consciousness induced by hypnosis. We studied high-density EEG in 9 healthy participants during eyes-closed wakefulness and during hypnosis, induced by a muscle relaxation and eyes fixation procedure....
Trends in Cognitive Sciences
December 22, 2022
Christopher Timmermann, Prisca R. Bauer, Olivia Gosseries et al.
145 citations
No contemporary unifying framework has been provided for the study of non-ordinary states of consciousness (NSCs) despite increased interest in hypnosis, meditation, and psychedelics. NSCs induce shifts in experiential contents (what appears to the experiencer) and/or structure (how it appears). This can allow the investigation of the plastic and dynamic nature of experience from a multiscale...
bioRxiv (Cold Spring Harbor Laboratory)
July 13, 2022
Andrea I. Luppi, Justine Y. Hansen, Ram Adapa et al.
5 citations
preprint
Abstract To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically-induced macroscale functional reorganisation, by relating the regional distribution of 19 neurotransmitter receptors and...
Frontiers in Psychology
2022
Charlotte Grégoire, Nolwenn Marie, Corine Sombrun et al.
20 citations
A symptom cluster is very common among oncological patients: cancer-related fatigue (CRF), emotional distress, sleep difficulties, pain, and cognitive difficulties. Clinical applications of interventions based on non-ordinary states of consciousness, mostly hypnosis and meditation, are starting to be investigated in oncology settings. They revealed encouraging results in terms of improvements...
Quality of Life Research
October 6, 2020
Charlotte Grégoire, Marie-Elisabeth Faymonville, Audrey Vanhaudenhuyse et al.
25 citations
PURPOSE: Cancer patients often report low self-esteem and high emotional distress. Two factors seem particularly linked to these symptoms: emotion regulation strategies and mindfulness. The interest of hypnosis and self-care to relieve these symptoms is not well documented. Our randomized controlled trial aimed at assessing the effect of a group intervention combining self-hypnosis and...
Médecine Intensive Réanimation
July 30, 2020
Floriane Rousseaux, Aminata Bicego, Christophe Malengreaux et al.
2 citations
Cet article vise à comprendre comment les processus impliqués en hypnose peuvent augmenter le confort des patientshospitalisés aux soins intensifs. L’hypnose est un outil de plus en plus utilisé par les équipes médicales comme techniquecomplémentaire aux approches biomédicales usuelles. De nombreuses études ont démontré ses effets dans différentscontextes (chirurgie, douleurs chroniques,...
OBM Integrative and Complementary Medicine
May 9, 2020
Audrey Vanhaudenhuyse, Anne‐Sophie Nyssen, Marie-Elisabeth Faymonville
22 citations
Hypnosis is a modified state of consciousness widely used to decrease pain perception in research protocols and clinical practice. In recent decades, hypnosis has been increasingly proposed to patients to re-engage their resources and capacities to modulate pain and emotional distress and to improve their treatment and recovery of well-being. Neuroimaging research helps clinicians to understand...
Clinical Neurophysiology
November 27, 2019
Olivia Gosseries, Matteo Fecchio, Audrey Wolff et al.
https://doi.org/10.1016/j.clinph.2019.11.011 1388-2457/ 2019 The Authors. Published by Elsevier B.V. on behalf of In This is an open access article under the CC BY-NC-ND license (http://creativ Cognitive trance is defined as a volitional, purposeful and selfinduced modified state of consciousness (inherited from shamanic traditional practice), characterized by lucid but narrowed awareness of...