Neuroimage
October 15, 2019
Guo-Rong Wu, Carol di Perri, Vanessa Charland-Verville et al.
Functional imaging research has already contributed with several results to the study of neural correlates of consciousness. Apart from task-related activation derived in fMRI, PET based glucose metabolism rate or cerebral blood flow account for a considerable proportion of the study of brain activity under different levels of consciousness. Resting state functional connectivity MRI is playing...
Scientific Reports
October 1, 2019
Charlotte Martial, Armand Mensen, Vanessa Charland-Verville et al.
36 citations
The neurobiological basis of near-death experiences (NDEs) is unknown, but a few studies attempted to investigate it by reproducing in laboratory settings phenomenological experiences that seem to closely resemble NDEs. So far, no study has induced NDE-like features via hypnotic modulation while simultaneously measuring changes in brain activity using high-density EEG. Five volunteers who...
Frontiers in Systems Neuroscience
August 14, 2019
Vincent Bonhomme, Cécile Staquet, Javier Montupil et al.
109 citations
General anesthesia reversibly alters consciousness, without shutting down the brain globally. Depending on the anesthetic agent and dose, it may produce different consciousness states including a complete absence of subjective experience (unconsciousness), a conscious experience without perception of the environment (disconnected consciousness, like during dreaming), or episodes of oriented...
Functional MRI
December 1, 2018
Nasim Mortazavi, Cécile Staquet, Audrey Vanhaudenhuyse et al.
This chapter reviews current knowledge of the effects of hypnotic anesthetic agents on brain resting-state networks (RSNs) that sustain consciousness. Although full exploration of the networks under anesthesia is not yet available, current evidence indicates that anesthetic agents with hypnotic properties dose-dependently modulate RSN functioning. Each anesthetic agent has specific effects that...
Frontiers in Neurology
August 28, 2018
Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Aurore Thibaut et al.
Despite recent advances in our understanding of consciousness disorders, accurate diagnosis of severely brain-damaged patients is still a major clinical challenge. We here present the case of a patient who was considered in an unresponsive wakefulness syndrome/vegetative state for 20 years. Repeated standardized behavioral examinations combined to neuroimaging assessments allowed us to show...
Frontiers in Neuroscience
2018
Rajanikant Panda, Olivia Gosseries, Audrey Vanhaudenhuyse et al.
2 citations
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Anesthesiology
August 9, 2016
Vincent Bonhomme, Audrey Vanhaudenhuyse, Athena Demertzi et al.
206 citations
BACKGROUND: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing...
PLoS One
June 30, 2014
Enrico Amico, Francisco Gómez, Carol di Perri et al.
115 citations
BACKGROUND: Recent studies have been shown that functional connectivity of cerebral areas is not a static phenomenon, but exhibits spontaneous fluctuations over time. There is evidence that fluctuating connectivity is an intrinsic phenomenon of brain dynamics that persists during anesthesia. Lately, point process analysis applied on functional data has revealed that much of the information...
PLoS One
March 27, 2013
Marie Thonnard, Vanessa Charland-Verville, Serge Brédart et al.
140 citations
Since the dawn of time, Near-Death Experiences (NDEs) have intrigued and, nowadays, are still not fully explained. Since reports of NDEs are proposed to be imagined events, and since memories of imagined events have, on average, fewer phenomenological characteristics than real events memories, we here compared phenomenological characteristics of NDEs reports with memories of imagined and real...
Neuroimage
May 15, 2011
Christophe Phillips, Marie-Aurélie Bruno, Pierre Maquet et al.
The vegetative state is a devastating condition where patients awaken from their coma (i.e., open their eyes) but fail to show any behavioural sign of conscious awareness. Locked-in syndrome patients also awaken from their coma and are unable to show any motor response to command (except for small eye movements or blinks) but recover full conscious awareness of self and environment. Bedside...
Medecine sciences : M/S
January 2011
Marie Thonnard, Melanie Boly, Marie-Aurélie Bruno et al.
Vegetative and minimally conscious states diagnosis remained a major clinical challenge. New paradigms such as measurement of the global cerebral metabolism, the structural and functional integrity of fronto-parietal network, or the spontaneous activity in resting state have been shown to be helpful to disentangle vegetative from minimally conscious patients. Active neuroimagery paradigms also...
Anesthesiology
September 30, 2010
Pierre Boveroux, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno et al.
645 citations
BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during...
Journal of Cognitive Neuroscience
June 1, 2010
Audrey Vanhaudenhuyse, Athena Demertzi, Manuel Schabus et al.
460 citations
Evidence from functional neuroimaging studies on resting state suggests that there are two distinct anticorrelated cortical systems that mediate conscious awareness: an "extrinsic" system that encompasses lateral fronto-parietal areas and has been linked with processes of external input (external awareness), and an "intrinsic" system which encompasses mainly medial brain areas and has been...
Annals of the New York Academy of Sciences
May 1, 2008
Melanie Boly, Christophe Phillips, L. Tshibanda et al.
396 citations
Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and behavior is proposed, and common resting-state...
International Anesthesiology Clinics
2008
Pierre Boveroux, Vincent Bonhomme, Melanie Boly et al.
44 citations
peer reviewed