Skip to content

Improvement of mindfulness skills during Mindfulness-Based Cognitive Therapy predicts long-term reductions of neuroticism in persons with recurrent depression in remission.

Philip Spinhoven, Marloes J. Huijbers, Johan Ormel, Anne E. M. Speckens

Journal of Affective Disorders April 15, 2017 DOI: 10.1016/j.jad.2017.02.011 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Uncontrolled clinical study using data from two randomized controlled trials Peer reviewed
Sample size 278
Population Participants with recurrent depression in remission
Intervention Mindfulness-Based Cognitive Therapy (MBCT)
Duration 15-month follow-up
Measures FFMQ, NEO-PI-R, IDS-C
Topics Meditation Depression
Keywords Mindfulness-based cognitive therapy Recurrent depression Remission
Key findings Following MBCT, participants showed significant improvement in mindfulness skills and, at 15-month follow-up, lower neuroticism and higher conscientiousness. Large improvements in mindfulness after treatment predicted long-term reductions in neuroticism but not conscientiousness; improvements in acting with awareness specifically predicted lower neuroticism. The authors argue MBCT could be a viable intervention to target neuroticism, a key risk factor for recurrent depression, though the design precludes causal conclusions.

Abstract

This study examined whether changes in mindfulness skills following Mindfulness-based Cognitive Therapy (MBCT) are predictive of long-term changes in personality traits. Using data from the MOMENT study, we included 278 participants with recurrent depression in remission allocated to Mindfulness-Based Cognitive Therapy (MBCT). Mindfulness skills were measured with the FFMQ at baseline, after treatment and at 15-month follow-up and personality traits with the NEO-PI-R at baseline and follow-up. For 138 participants, complete repeated assessments of mindfulness and personality traits were available. Following MBCT participants manifested significant improvement of mindfulness skills. Moreover, at 15-month follow-up participants showed significantly lower levels of neuroticism and higher levels of conscientiousness. Large improvements in mindfulness skills after treatment predicted the long-term changes in neuroticism but not in conscientiousness, while controlling for use of maintenance antidepressant medication, baseline depression severity and change in depression severity during follow-up (IDS-C). In particular improvements in the facets of acting with awareness predicted lower levels of neuroticism. Sensitivity analyses with multiple data imputation yielded similar results. Uncontrolled clinical study with substantial attrition based on data of two randomized controlled trials. The design of the present study precludes to establish whether there is any causal association between changes in mindfulness and subsequent changes in neuroticism. MBCT could be a viable intervention to directly target one of the most important risk factors for onset and maintenance of recurrent depression and other mental disorders, i.e. neuroticism.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

Citations in the library

Cited by 8

and 3 more in the library

Cites 18

and 13 more in the library

Explore topics