This protocol describes a systematic review and meta-analysis assessing the efficacy and safety of classic serotonergic psychedelics and related serotonergic ergoline or lysergamide compounds in cluster headache and migraine. The review will include clinical studies evaluating psilocybin, psilocin, LSD, LSA, DMT/ayahuasca, mescaline, BOL-148 / 2-bromo-LSD / bromolysergide, lisuride,...
Psychedelics have re-emerged as promising therapeutics for neuropsychiatric disorders, including depression, anxiety, post-traumatic stress disorder, and substance use disorders. While their beneficial effects are largely attributed to serotonin 2A (5-HT2A) receptor activation, psychedelics exhibit substantial diversity in chemical structure, receptor binding kinetics, metabolism, and duration...
Chapter 10 : The Doors of Perception explores how altered states unlock consciousness’ vast but ordinarily constrained potential. Drawing on Aldous Huxley’s mescaline experiments and his notion of the brain as a “reducing valve,” the chapter follows how chemical mysticism, meditative practices, and rational inquiry by figures such as Richard Feynman open access to hidden territories of...
En este artículo presentamos aportes de viajeros, investigadores (antropólogos, médicos, psicólogos, químicos, sociólogos), así como sabios ancestrales, todos ellos, exploradores del ámbito de las plantas maestras en Ecuador, país creado en 1830 y ubicado en la región noroccidental de América del Sur, con una población de 18,14 millones de habitantes. Ecuador resalta por su diversidad...
Attention deficit and hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder (Drechsler et al., 2020). Recently, psychedelics have become of interest regarding developing treatment options for ADHD. The aim of this systematic review is to find all studies from the APA PsychInfo and MEDLINE databases, where psychedelics have been used for ADHD and assess whether further clinical...
Chronic pain is common, costly, and for many, remains inadequately treated by existing pharmacologic and non-pharmacologic approaches. In parallel with growing dissatisfaction with conventional therapies, classic serotonergic psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), ayahuasca, N,N-dimethyltryptamine (DMT), and mescaline, administered alone or within...
European PsychiatryJune 1, 2026A. M. Matas Ochoa, A. R. Quiroga, I. D. Sacristán
Introduction Psychedelics are hallucinogenic agents that are awakening scientific interest in recent years, especially in the field of mental health. Psychedelics induce non-ordinary states of consciousness and alterations in the emotions and in cognition and could be beneficial in treating some mental illness. Objectives The objective of the poster is to expand knowledge about emerging...
Introduction MM120 (lysergide D-tartrate, a formulation of LSD) is under development as a potential treatment for generalized anxiety and major depressive disorders. How psychedelic drugs interact at the TrkB receptor, a key target of neuroplasticity, is not reported. Objectives The study evaluated binding and functional activity of known serotonergic psychedelic compounds and SRI fluoxetine at...
The impact of classic psychedelics (5-HT2A receptor agonists) on personality traits has been studied for decades, and it has been hypothesized that the mechanisms underlying these changes are linked to agonism at cortical serotonergic 5-HT2A receptors. However, research results are contradictory. Therefore, the present paper aims to systematically evaluate the effects of psychedelics on...
Despite renewed investigations into classical psychedelic compounds, their pharmacokinetic profiles remain incompletely understood. This systematic review collated data from healthy adult volunteers on the pharmacokinetic properties of lysergic acid diethylamide (LSD), psilocybin, dimethyltryptamine (DMT), mescaline, and 5-methoxy-N,N-dimethyltryptamine (5-MEO-DMT). We identified 32 eligible...