Journal of Psychopharmacology
November 1, 2006
Roland W. Freudenmann, Carlos Schönfeldt-lecuona, Manfred Spitzer et al.
4 citations
Depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (SSRIs) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. We report findings in a patient suffering from MDMA-induced depression which was refractory to several antidepressive medications including selective noradrenergic reuptake inhibitor (SNRI) and SSRI. An add-on...
Neurotoxicology and Teratology
October 21, 2006
Brian J. Piper
54 citations
The entactogen +/-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug among college, high school, and, occasionally, middle school students. Preclinical research examining the acute and long-term effects of MDMA has predominately been conducted in reproductively mature subjects but there has been increasing interest in adolescent and in utero exposure. This review...
Studia Mythologica Slavica
October 16, 2006
Suzana Marjanić
4 citations
I shall attempt to interpret witches' zoopsychonavigations in the worlds of Croatian legends as (possible) aspects of shamanistic techniques of ecstasy (and trance), in the framework of which I shall be trying to designate the concept of zoopsychonavigation as the border of permeation between shamanistic ecstatic experiences and the witches' experience of lethargy.In addition to the above...
Neuroscience
October 13, 2006
R D Crean, S A Davis, S N Von Huben et al.
Severe and malignant hyperthermia is a frequently reported factor in emergency department (ED) visits and fatalities in which use of amphetamine drugs, such as (+/-)3,4-methylenedioxymethamphetamine (MDMA), (+/-)3,4-methylenedioxyamphetamine (MDA) and (+)methamphetamine (METH), is confirmed. Individuals who use "ecstasy" are also often exposed, intentionally or otherwise, to several of these...
Chemical Research in Toxicology
October 2006
Nuno Milhazes, Teresa Cunha-Oliveira, Pedro Martins et al.
The toxicological and redox profiles of MDMA and its major metabolites (MDA, alpha-methyldopamine, N-methyl-alpha-methyldopamine, 6-hydroxy-alpha-methyldopamine, 3-methoxy-alpha-methyldopamine) were studied to establish a structure-toxicity relationship and determine their individual contribution to cell death induction by apoptosis and/or necrosis. The results of the comparative toxicity...
Psychopharmacology
October 2006
Jonathan P. Roiser, Robert D Rogers, Lynnette J Cook et al.
3, 4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a popular drug of abuse known to result in depletions of the serotonin (5-HT) system. A number of studies have reported that ecstasy users differ from controls on a variety of measures of cognitive function. However, the literature is not consistent and many negative findings were also reported. One reason for such inconsistency might be...
Neuroscience
September 15, 2006
W W Blessing, A Zilm, Y Ootsuka
Clozapine, an atypical antipsychotic agent important for the treatment of schizophrenia, has marked inhibitory effects on sympathetic outflow to the thermoregulatory cutaneous circulation. In rabbits clozapine reverses ear pinna vasoconstriction induced either by administration of MDMA (3,4-methylenedioxymethamphetamine, ecstasy) or by exposing the animal to a cold environment. In rats, both...
Journal of Psychoactive Drugs
September 1, 2006
Arthur Hastings
This research explored whether hypnotic suggestion could produce a subjective mindbody condition similar to that produced by the psychoactive drug methylenedioxy methamphetamine (MDMA, Ecstasy). Twelve participants received posthypnotic instructions to re-experience an MDMA-like state posthypnotically, similar to one in their prior experience, for one hour. Three separate self report measures...
Journal of Psychopharmacology
September 1, 2006
Harry Sumnall, Jon C. Cole, Lisa Jerome
117 citations
Previous investigations of the subjective effects of MDMA (material sold as ecstasy) have conducted interviews and surveys of various groups of ecstasy users within particular sub-populations. This study examined subjective drug effects reported by different sub-populations of ecstasy users and explored whether the function or purpose served by using ecstasy influenced the nature of the drug...
Addiction
August 8, 2006
J. G. Ramaekers, K. P. C. Kuypers, N. Samyn
90 citations
ABSTRACT Background 3,4‐methylenedioxymethamphetamine (MDMA) is currently one of the most popular drugs of abuse in Europe. Its increasing use over the last decade has led to concern regarding possible adverse effects on driving. The aims of the present study were to investigate the acute effects of MDMA on actual driving performance during the intoxication and withdrawal phase. Methods...