Page 300 of 345: studies 2,991 to 3,000 of 3,446, newest first. Back to the MDMA overview
Human Flourishing October 18, 2021 Andrew Briggs, Michael J. Reiss
For most of us, there are times when we feel transported beyond the everyday, when we feel a burst of joy or a sense that there is great meaning to life, that everything is connected or that, somehow, all is well. This is an appreciation of the transcendent. Some describe their experience of the transcendent in terms of their relationship with God. Nietzsche explored the idea of...
International Journal of Environmental Research and Public Health October 1, 2021 S. Amigó 3 citations
Background: This study consists of a brief psychological intervention, which uses Self-Regulation Therapy (SRT, procedure based on suggestion and classical conditioning), to improve coping with stress and emotionality by reproducing the positive effects of illegal drugs: cannabis, cocaine, ecstasy. Method: 15 volunteers (8 males, 7 females), with a mean age of 24.6 (SD = 4.4), underwent...
Biochemical Pharmacology October 1, 2021 Alexandra Sachkova, David Alexander Doetsch, Ole Jensen et al. 11 citations
Although psychostimulants apparently do cross the BBB, it is poorly understood how these hydrophilic and positively charged molecules can pass the blood-brain barrier (BBB). That may be mediated by a genetically still uncharacterized H+/OC antiporter with high activity at the BBB. We studied the uptake of 16 psychostimulants and hallucinogens with hCMEC/D3 cells using the prototypic inhibitor...
bioRxiv Preprint Server September 24, 2021 Sophia Khom, Jacques D. Nguyen, Sophia A. Vandewater et al. preprint
Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we investigated whether female rats escalate self-administration of methylone, 3,4-methylenedioxypentedrone (pentylone), and MDMA and then studied...
Journal of Analytical Toxicology September 17, 2021 Elba Arango, Allison Toriello, Zoila Rosario et al. 17 citations
Ketamine is a dissociative anesthetic used in veterinary and human medicine since the 1970s. Its clinical use has expanded to control of seizures, by pre-hospital emergency medical services (EMS), and is finding new purpose as an analgesic alternative and antidepressant. Ketamine brings hope for effective management of chronic pain in the absence of opioids and decreasing suicidal ideations;...
Bulletin of Integrative Psychiatry September 15, 2021 Dan Cătălin Oprea, Loretta Epure, Vasile Chiriță et al.
Psychedelic drugs (also called hallucinogens, psychotogenics, psycholytics, entheogens) are substances that act mainly on the 5-HT2 serotonergic receptor.There are two main groups of psychedelics: indoleamines (lysergic acid diethylamide-LSD, N, N-dimethyltryptamine-DMT, and psilocybin) and phenethylamines (mescaline, dimethoxymethamphetamine-DOM, methylenedioxyamphetamine-MDA, and...
Preprints.org September 7, 2021 S. Amigó 1 citation preprint
Background: This study consists of a brief psychological intervention, which uses the Self-Regulation Therapy (SRT, procedure based on suggestion and classical conditioning), to improve coping with stress and emotionality by reproducing the positive effects of illegal drugs: cannabis, cocaine, ecstasy. Method: 15 volunteers (8 males, 7 females), with a mean age of 24.67 (SD = 4.43), underwent...
Social Science Research Network August 25, 2021 Greg F. Ferenstein preprint
Abstract: Field observations of underground, illicit, and private ceremonial substance use has been central to ongoing research in psychedelics-assisted therapy. This paper explores a novel use of MDA in a ceremonial virtual environment. Participant interviews and field notes are used to explore the reported therapeutic effects of this understudied entactogen. Users report therapeutic effects...
Life July 29, 2021 Dominika Psiuk, Emilia Nowak, Krystian Cholewa et al. 13 citations
Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for this disorder. Recently, interest has revolved around the use of serotonergic psychedelics to reduce the symptoms of depression. In this systematic review, we summarize the currently available knowledge on the safety and efficacy of psychedelic...
Cells July 27, 2021 Dasiel O Borroto-Escuela, Patrizia Ambrogini, Manuel Narváez et al. 29 citations
The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The existence of D2R-5-HT2AR heterocomplexes can help explain the anti-schizophrenic effects of atypical antipsychotic drugs not only based on...