A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is associated with sustained improvements in life satisfaction and mindfulness-related capacities, along with a reduction in psychopathological symptoms.
MDMA, a popular recreational drug in Europe, has stimulant-like effects on driving that vary by task. In a double-blind, placebo-controlled crossover study, 18 recreational MDMA users took 75 mg MDMA, 20 mg methylphenidate, or placebo. During the intoxication phase (3–5 hours after dosing), both MDMA and methylphenidate improved road-tracking performance, reducing the standard deviation of lateral position by about 2 cm compared to placebo. However, MDMA impaired car-following performance, causing subjects to overcorrect in response to speed changes of a leading vehicle. No driving impairments were observed during the withdrawal phase (27–29 hours after dosing).