PROTEOMICS
January 2011
Vijay Upreti, Kwan–hoon Moon, Li‐rong Yu et al.
It is well established that 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) causes acute liver damage in animals and humans. The aim of this study was to identify and characterize oxidative modification and inactivation of cytosolic proteins in MDMA-exposed rats. Markedly increased levels of oxidized and nitrated cytosolic proteins were detected 12 h after the second administration of two...
2011
Simon David Fisher
Rationale: There is evidence that the serotonin (5-HT) deficits and related cognitive and mood impairments caused by +/-3,4- methylenedioxymethamphetamine (MDMA) may be mediated by neuroadaptations of the 5-HT1A autoreceptor. Objectives: The increase in sensitivity of the 5-HT1A autoreceptor caused by highdose, repeated MDMA treatment was assessed neurochemically, by measuring 5- HTP...
Addiction Biology
2011
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
The Primary Care Companion For CNS Disorders
2011
Persistent Psychosis After a Single Ingestion of "Ecstasy" (MDMA).
Neuropharmacology
2011
Laura Hondebrink, Jan Meulenbelt, Marieke Meijer et al.
The popular synthetic drug of abuse 3,4-methylenedioxymethampetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) act mainly on the serotonergic system, though they also increase the amount of extracellular dopamine (DA) in the brain, presumably via reversal of the membrane dopamine transporter (DAT). As the involvement of exocytotic DA release is debated, we investigated if...
Neuropharmacology
2011
Robert W Gould, H Donald Gage, Matthew L Banks et al.
Cocaine self-administration alters brain dopaminergic and serotonergic function primarily in mesolimbic and prefrontal brain regions whereas 3,4-methylenedioxymethamphetamine (MDMA) self-administration predominately alters brain serotonergic function in a more widespread distribution across cortical regions. We previously reported that, compared to drug-naïve rhesus monkeys, self-administration...
Case reports in pulmonology
2011
L L W Verhaert
Case. A 45-year-old man with a blank medical history presented at the emergency room with dizziness and cyanosis. Physical examination showed cyanosis with a peripheral saturation (SpO(2)) of 85%, he did not respond to supplemental oxygen. Arterial blood gas analysis showed a striking chocolate brown colour. Based on these data, we determined the arterial methaemoglobin concentration. This was...
British Journal of Pharmacology
December 30, 2010
Susan Schenk, David Gittings, Joyce Colussi‐mas
61 citations
BACKGROUND AND PURPOSE Animal models of drug‐seeking suggest that exposure to cues associated with self‐administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH The effects of priming injections of dopamine and 5‐HT agonists on drug‐seeking and effects of dopamine antagonists on methylenedioxymethamphetamine...
Neuroscience & Biobehavioral Reviews
December 22, 2010
MDMA ("ecstasy") abuse as an example of dopamine neuroplasticity.
Biological Psychiatry
December 1, 2010
Is ecstasy an empathogen?