Physiology & Behavior
August 1, 2006
María E. Reverón, Esther Y. Maier, Christine L. Duvauchelle
23 citations
Hyperthermia and hyperlocomotor activity are commonly reported acute effects of high dose, experimenter-delivered 3,4-methylenedioxymethamphetamine (MDMA). The current investigation was performed to determine short- to long-term physiological and behavioral changes induced by moderate intake MDMA self-administration. In the present study, rats self-administered MDMA (approx. 2.0-7.0 mg/kg/day)...
Annals of the New York Academy of Sciences
August 1, 2006
Ilaria Tamburini, Fabio Blandini, Marco Gesi et al.
24 citations
Abstract: Several studies, carried out in chronic (+/−) 3,4‐methylenedioxymethamphetamine (MDMA) abusers, have shown memory loss and cognitive impairment, as well as persistent electroencephalographic changes. This suggests that, at least in humans, forebrain areas, including the limbic system, might be altered by MDMA. Consistently, recent experimental evidences suggest that, in rodents, MDMA,...
Annals of the New York Academy of Sciences
August 1, 2006
Jerrold S. Meyer, Matthew E. Brevard, Brian J. Piper et al.
40 citations
Abstract: We used functional magnetic resonance imaging (fMRI) to investigate the acute effects of a recreational dose (1 mg/kg p.o.) of 3,4‐methylenedioxymethamphetamine (MDMA) on regional brain activity in awake, restrained marmoset monkeys. In a second study, magnetic resonance spectroscopy (MRS) and postmortem measurements of serotonin transporter (SERT) binding and serotonin (5‐HT)...
Annals of the New York Academy of Sciences
August 1, 2006
Raquel Faria, Ana Magalhães, Pedro Monteiro et al.
29 citations
Abstract: Long‐term behavioral consequences of the neurotoxicity produced by 3,4‐methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% saline in the same protocol. Ten days after exposure, the behavioral effects of...
Annals of the New York Academy of Sciences
August 1, 2006
Filippo Sean Giorgi, Gloria Lazzeri, Gianfranco Natale et al.
33 citations
Abstract: In the past decades, there was a massive increase in the abuse of methylenedioxymethamphetamine (MDMA) in the Western countries. Seizure onset after MDMA is considered to be related mainly to its acute systemic effects (e.g., hyponatremia and hyperthermia). However, additional mechanisms might concur to it as well. Experiments aimed at disclosing the basis for such an acute effect...
Addiction
July 8, 2006
Roland W. Freudenmann, Florian Öxler, Sabine Bernschneider‐reif
201 citations
ABSTRACT Background Little is known about the origin of methylenedioxymethamphetamine (MDMA, ecstasy). The most commonly repeated statement in the medical literature is that MDMA was synthesized by the German pharmaceutical company Merck in 1912 in order to develop an appetite suppressor. Aim To reconstruct the true story of the first known description of MDMA at Merck using the original...
Human psychopharmacology
July 2006
A C Parrott, J Rodgers, Tom Buchanan et al.
Non-drug factors such as ambient temperature can heighten the adverse effects of MDMA (3,4-methylendioxymethamphetamine) in animals. We assessed whether dancing and feeling hot on Ecstasy would be associated with more psychobiological problems in recreational users. In an internet study, 206 unpaid participants (modal age 16-24) reported that they had used recreational Ecstasy/MDMA. They...
Neuropsychopharmacology
July 2006
Michael John Morgan, Lara Chiara Impallomeni, Alessandro Pirona et al.
Ecstasy (MDMA; 3,4-methylenedioxymethamphetamine) has a well-recognized neurotoxic effect on central serotonergic (5-HT) systems in animals, and there is some evidence of persistent serotonergic dysregulation in human ecstasy users. Serotonin is believed to mediate impulsive behavior and effective decision-making. Thus, the aim of the present study was to investigate impulsive behavior and...
European Journal of Neuroscience
July 1, 2006
Linda Ferrington, Eszter Kirilly, Douglas E. Mcbean et al.
21 citations
Abstract Acutely, 3,4,‐methylenedioxymethamphetamine (MDMA) induces cerebrovascular dysfunction [ Quate et al ., (2004) Psychopharmacol. , 173 , 287–295]. In the longer term the same single dose results in depletion of 5‐hydroxytrptamine (5‐HT) nerve terminals. In this study we examined the cerebrovascular consequences of this persistent neurodegeneration, and the acute effects of subsequent...
European Journal of Neuroscience
July 1, 2006
Kevin T. Ball, Daniel Budreau, George V. Rebec
40 citations
Abstract To investigate the neuronal mechanisms underlying the behavioural alterations that accompany repeated exposure to MDMA (ecstasy), we recorded the activity of > 200 striatal units in response to multiple, intermittent, locomotor‐activating doses (5.0 mg/kg) of MDMA. Rats were treated with once‐daily injections of either saline or MDMA for 5 days when housed in their home cage, followed...