Journal of Psychopharmacology
March 30, 2006
Fabrizio Schifano, John Corkery, Paolo Deluca et al.
96 citations
In the last decade, a global trend of escalating ecstasy (MDMA, MDA, MDEA, MBDB) use was observed. Mentions on medical death certificates, last year's ecstasy use, number of drug offenders, seizures, prices and dosage levels figures were used for this descriptive and correlational study. Figures (1994ñ2003) were taken from the UK General Mortality Registers, from the Home Office Statistical...
Addiction
March 24, 2006
Chelsea A. Baylen, Harold Rosenberg
214 citations
ABSTRACT Aim Although several relatively recent reviews have summarized the neuropsychiatric effects associated with chronic ecstasy use, there is no published comprehensive review of studies on the acute subjective effects (ASEs) of MDMA/ecstasy. Design The present study reviewed the prevalence, intensity and duration of ASEs collected from 24 studies that provided frequency data on the...
Journal of Clinical and Experimental Neuropsychology
March 21, 2006
Jeff Ward, Kate Hall, Catherine Haslam
28 citations
The popular recreational drug MDMA or "ecstasy" is a selective serotonin neurotoxin in many species and has been found to be associated with memory dysfunction in human beings. Recent studies suggest that this impairment persists after cessation of use for periods up to at least one year. However, there is no clear indication as yet concerning which stage of memory processing is impaired as a...
Psychopharmacology
March 15, 2006
Michael H. Baumann, Xiaoying Wang, Richard B Rothman
269 citations
RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate. OBJECTIVE: The present paper reviews four specific issues...
Neurology
March 13, 2006
Konstantine K. Zakzanis, Zachariah Campbell
54 citations
The authors further investigated the functional consequences of continued neurotoxicity of (+/-)3,4-methylenedioxymethamphetamine (MDMA) use. Fifteen participants who were previously given a brief neuropsychological battery were tested for a third time 2 years after baseline. At 2 years, seven participants were still using MDMA, whereas eight participants had become abstinent from MDMA since...
Journal of Psychoactive Drugs
March 2006
Rüssel S. Falck, Robert G Carlson, Jichuan Wang et al.
This study describes the lifetime prevalence, correlates, and age of onset of selected psychiatric disorders among a community sample of MDMA users (n = 402), aged 18 to 30, in Ohio. Participants responded to interviewer-administered questionnaires, including sections of the computerized Diagnostic Interview Schedule for DSM-IV. Fifty-five percent of the sample had at least one lifetime...
Journal of Psychopharmacology
March 1, 2006
Shaista Hayat, Robert J. Williams, Marcus Rattray
There is much evidence from animal studies that the recreational drug MDMA is a selective toxin which damages serotonin nerve terminals and axons. These in vivostudies show that an interaction between MDMA and the serotonin transporter protein (SERT) is the .rst step in toxicity. To further our understanding of the biochemical processes of MDMA toxicity we wished to use an in vitromodel for...
Journal of Psychoactive Drugs
March 2006
Murilo Campos Battisti, Ana Regina Noto, Solange Nappo et al.
The use of Ecstasy in Brazil has gained visibility in recent years. Nevertheless, scientific data on this issue remain scarce. The present study focused on clarifying this phenomenon by means of qualitative and ethnographic research. Observational studies (N = 8), information obtained from key informants (N = 14) and interviews with Ecstasy users (N = 32) from the city of São Paulo were part of...
Journal of Psychopharmacology
March 2006
Jörg Daumann, Bianca Till, Thomas Fischermann et al.
Numerous animal studies have been able to demonstrate neurotoxic damage to central serotonergic systems after exposure to 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). It has been suggested that a high loudness dependence of auditory evoked potentials (LDAEP) and, particularly, of the tangential N1/P2 source activity is associated with a low functioning of serotonergic activity. Therefore,...
Journal of Psychopharmacology
March 2006
Eleanor J Bull, Veronica Porkess, Michael Rigby et al.
The current study examined the long-term effect of brief exposure to 3,4-methylenedioxymethamphetamine (MDMA) on local cerebral glucose utilization (LCGU) in specific brain regions immediately following administration of the 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Wistar rats (post-natal day (PND) 28, n = 24) were administered MDMA (5 mg/kg, i.p.) or...