Bba Section Nucleic Acids and Protein Synthesis
November 22, 1979
James B. Mahony, Ian R. Brown
15 citations
Intravenous injection of (+)-lysergic acid diethylamide into young rabbits induced a transient brain-specific disaggregation of polysomes to monosomes. Investigation of the fate of mRNA revealed that brain poly(A+)mRNA was conserved. In particular, mRNA coding for brain-specific S100 protein was not degraded, nor was it released into free ribonucleoprotein particles. Following the (+)-lysergic...
Science
August 3, 1979
Michael E. Trulson, Barry L. Jacobs
44 citations
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d -lysergic acid diethylamide (LSD) while studying the activity of raphe neurons in freely moving cats. Although the results provide general support for the hypothesis, there were several important...
Psychopharmacology
April 25, 1979
D Ruffing, B Kovacic, S Demetriou et al.
The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio four schedule (FR4), i.e., every fourth press earned a reward of 0.01 ml sugar sweetened milk. LSD (0.1 mg/kg) or increasing doses of DMT (1.0, 3.2, and 10.0 mg/kg) were...
Brain Research
February 1, 1979
H S Ahn, M H Makman
The influence of D-lysergic acid diethylamide (LSD) and mescaline on adenylate cyclase activity was studied in homogenates of Cebus and rhesus monkey anterior limbic cortex (ALC), frontal cortex (FC), caudate nucleus and retina. Previous studies have shown these tissues to contain dopamine-stimulated adenylate cyclase (AC). In addition, we are now reporting the presence of a dopamine-sensitive...
Journal of Psychedelic Drugs
1979
Albert Hofmann
108 citations
(1979). How LSD Originated. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 53-60.
Proceedings of the National Academy of Sciences
December 1, 1978
P M Whitaker, P Seeman
Since it was known that d-lysergic acid diethylamide (LSD) affected catecholaminergic as well as serotoninergic neurons, the objective in this study was to enhance the selectivity of [3H]LSD binding to serotonin receptors in vitro by using crude homogenates of calf caudate. In the presence of a combination of 50 nM each of phentolamine (added to preclude the binding of [3H]LSD to...
Journal of Pharmacology and Experimental Therapeutics
December 1, 1978
Mark A. Geyer, Lyle R. Petersen, Gary J. Rose et al.
69 citations
Tactile startle responding by male Sprague-Dawley rats given 60 presentations of air-puff stimuli (37.5 psi) was measured after the intraperitoneal administration of graded doses of hallucinogens and other psychoactive drugs. Among the drugs tested were the indoleamine-derived compounds, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine and psilocin, and the phenylethylamine-derived...
Journal of Pediatric Ophthalmology & Strabismus
September 1, 1978
Creig Hoyt
15 citations
two patients born to others habitually using LSD during pregnancy are described. Each infant had an isolated bilateral optic disc anomaly suggesting an early intrauterine insult. The possibility that LSD may express its teratogenicity in such relative benign fashion is suggested and the importance of further investigations concerning the etiology of disc anomalies is stressed.
Drug and Alcohol Dependence
May 1, 1978
M Nozaki, D B Vaupel, L D Bright et al.
8 citations
3-Methoxy-4,5-methylenedioxyamphetamine (MMDA), which has been reported to have hallucinogenic actions in man, was compared to LSD in single dose, antagonist interaction, cross-tolerance and appetite suppression studie in the dog. In single doses, MMDA partially resembled LSD: both facilitated the flexor reflex and produced tachypnea, hyperthermia, and analgesia; however, MMDA had greater...
Drug and Alcohol Dependence
March 1, 1978
William R. Martin, D B Vaupel, M Nozaki et al.
22 citations
The effects of several indoleamines and phenethylamines were studied in the chronic spinal dog and compared with two standard drugs, LSD and amphetamine. In the nontolerant chronic spinal dog, their effects on a variety of physiologic and behavioral functions were measured in untreated dogs, as well as dogs treated with certain antagonists. The effects of the antagonists phenoxybenzamine and...