Pharmacology, biochemistry, and behavior
July 1989
D B Vaupel
The pharmacological effects of individual and combined intravenous doses of the antihistamine tripelennamine and the psychotomimetic sigma benzomorphan opioid derivative, N-allylnormetazocine (NANM), on nociceptive reflexes, autonomic parameters and behavior were assessed in the chronic spinal dog. NANM (1.65 mg/kg, IV) produced antinociception, mydriasis, tachycardia, hyperthermia and...
Pharmacology, biochemistry, and behavior
September 1, 1982
D B Vaupel, E C Morton
The acute actions of five prototype hallucinogens administered SC on food consumption in 23 hr food deprived dogs were compared with the anorexic effect of d-amphetamine and the hyperphagic effect of sodium pentobarbital. Comparisons were made on the basis of dose-response relationships. Among the hallucinogens decreasing food intake, both LSD and atropine produced substantial anorexia, but the...
Drug and Alcohol Dependence
May 1, 1978
M Nozaki, D B Vaupel, L D Bright et al.
8 citations
3-Methoxy-4,5-methylenedioxyamphetamine (MMDA), which has been reported to have hallucinogenic actions in man, was compared to LSD in single dose, antagonist interaction, cross-tolerance and appetite suppression studie in the dog. In single doses, MMDA partially resembled LSD: both facilitated the flexor reflex and produced tachypnea, hyperthermia, and analgesia; however, MMDA had greater...
Drug and Alcohol Dependence
March 1, 1978
William R. Martin, D B Vaupel, M Nozaki et al.
22 citations
The effects of several indoleamines and phenethylamines were studied in the chronic spinal dog and compared with two standard drugs, LSD and amphetamine. In the nontolerant chronic spinal dog, their effects on a variety of physiologic and behavioral functions were measured in untreated dogs, as well as dogs treated with certain antagonists. The effects of the antagonists phenoxybenzamine and...