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LSD: all studies

Page 49 of 282: studies 481 to 490 of 2,815, newest first. Back to the LSD overview

Research

An animal model of schizophrenia based on chronic LSD administration: old idea, new results.

Neuropharmacology February 23, 2011 Danuta Marona‐lewicka, Charles D. Nichols, David E Nichols

Many people who take LSD experience a second temporal phase of LSD intoxication that is qualitatively different, and was described by Daniel Freedman as "clearly a paranoid state." We have previously shown that the discriminative stimulus effects of LSD in rats also occur in two temporal phases, with initial effects mediated by activation of 5-HT(2A) receptors (LSD30), and the later temporal...

Intrahippocampal LSD accelerates learning and desensitizes the 5-HT(2A) receptor in the rabbit, Romano et al.

Psychopharmacology October 1, 2010 Anthony G Romano, Jennifer L Quinn, Luchuan Li et al. 42 citations

Parenteral injections of d-lysergic acid diethylamide (LSD), a serotonin 5-HT(2A) receptor agonist, enhance eyeblink conditioning. Another hallucinogen, (±)-1(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), was shown to elicit a 5-HT(2A)-mediated behavior (head bobs) after injection into the hippocampus, a structure known to mediate trace eyeblink conditioning. This study aims...

Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats.

Pharmacology, Biochemistry, and Behavior September 1, 2010 Bryan A Killinger, Mary M Peet, Lisa E Baker 41 citations

Salvia divinorum is a small perennial shrub that has gained recent popularity among the drug-using subculture as a legal alternative to hallucinogens. Salvinorin A, the main active compound found in the S.divinorum plant, is an atypical hallucinogen with pharmacological selectivity at kappa opioid (KOP) receptor sites and is a unique non-nitrogenous neoclerodane diterpene which is structurally...

Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition.

Progress in Neuro-Psychopharmacology and Biological Psychiatry May 30, 2010 Tomáš Páleníček, Zdenek Hlinák, Vĕra Bubeníková‐valešová et al.

The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and...

Psychedelic Psychiatry: LSD from Clinic to Campus Erika Dyck

Canadian Journal of Health History April 1, 2010 Kenton Kroker 2 citations

Find information about UTP Journals. University of Toronto Press is Canada’s leading academic publisher and one of the largest university presses in North America, with particular strengths in the social sciences, humanities, and business. The Book Publishing Division is widely recognized in Canada for its strength in history, political science, sociology, Indigenous studies, and cultural...

A case of persistent visual hallucinations of faces following LSD abuse: a functional Magnetic Resonance Imaging study.

Neurocase April 2010 Giuseppe Iaria, Christopher J Fox, Michael Scheel et al.

In this study, we report the case of a patient experiencing hallucinations of faces that could be reliably precipitated by looking at trees. Using functional Magnetic Resonance Imaging (fMRI), we found that face hallucinations were associated with increased and decreased neural activity in a number of cortical regions. Within the same fusiform face area, however, we found significant decreased...