Archives of General Psychiatry
July 1, 1974
Solomon H. Snyder
25 citations
Several different molecular conformations of psychedelic drugs have been proposed to explain the very similar effects of drugs with markedly divergent chemical structures, such as mescaline andd-lysergic acid diethylamide (LSD). In some of these models, the α-carbon of methoxyamphetamine psychedelics approximates the asymmetric carbon No. 5 of LSD predicting that the (-) "R" isomer of the...
British Journal of Pharmacology
March 1, 1974
Philip Bradley, Ian Briggs
54 citations
The actions of 5‐methoxytryptamine (5‐MeOT), N,N ‐dimethyltryptamine (DMT), 5‐hydroxy‐ N,N ‐dimethyltryptamine (bufotenine, 5‐HODMT) and 5‐methoxy‐ N,N ‐dimethyltryptamine (5‐MeODMT), and their interactions with 5‐hydroxytryptamine (5‐HT), acetylcholine, (–)‐noradrenaline, and glutamate were studied by microiontophoresis on single neurones in the brain stem of rats anaesthetized with urethane...
Archives of General Psychiatry
1971
Solomon H. Snyder
30 citations
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated "STP." DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a...
Psychopharmacologia
September 1, 1970
W. R. Martin, J. W. Sloan
Tryptamine, infused intravenously in man, facilitates the patellar reflex, dilates pupils and elevates blood pressure. It also causes changes in vision and hearing, as well as nausea, vomiting, dizziness, sweating and heaviness of body. These changes are similar to those produced by LSD-like hallucinogens and are consistent with the hypothesis that LSD-like hallucinogens interact with...
Proceedings of the National Academy of Sciences
September 1, 1970
Sungzong Kang, Jack Peter Green
64 citations
Stereochemical considerations and total valence electron calculations suggest congruities among the ostensibly dissimilar hallucinogenic compounds, D-lysergic acid diethylamide (LSD), indolcalkylamines, and methoxylated amphetamines. In LSD the aromatic benzene ring A and the N-6 nitrogen are essential for hallucinogenic activity; these sites may react with the receptor. The conformations of...
American Journal of Psychiatry
September 1, 1968
Solomon H. Snyder, Louis A. Faillace, Herbert Weingartner
77 citations
DOM, a hallucinogen related to mescaline and amphetamine and designated "STP" by hippies, along with DOET, the ethyl homologue of DOM, were given in small doses to normal subjects in a double-blind study. Both drugs increased self-awareness and produced mild euphoria but no hallucinogenic or psychotomimetic effects. The two drugs "freed up" subjects' word associations without impairing memory...
Journal of Psychedelic Drugs
April 1, 1968
Janet Sherwood, Myron J. Stolaroff, Willis W. Harman
24 citations
Abstract The authors, by the simultaneous administration of massive doses of lysergic acid diethylamide (LSD) and mescaline, tried to produce a unique experience for the patient which is to be so profound and impressive that it changes the patient's own evaluation of his past life experiences and consequently may lead him to establish new values and a more realistic frame of reference than had...
Science
November 3, 1967
Solomon H. Snyder, Louis A. Faillace, Leo E. Hollister
146 citations
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic...
Archives of General Psychiatry
May 1, 1967
Malcolm B. Bowers
22 citations
THE PUBLIC has become aware of the increasing use of the major psychedelic substances (lysergic acid diethylamide [LSD], peyote, psilocybin, morning glory seeds) by certain individuals outside the contexts of supervised therapy and research.1,2Several excellent clinical studies have firmly documented the hazards of this Practice.4,5At a time when the scientific community has been gathering...
Journal of Asthma Research
1965
Harold A. Abramson, Anabela P. Rolo
21 citations
This paper is a continuation of our experiments with LSD-25 and similar compounds that have been carried out for the last thirteen years.1 It employs the same technique described previously2 to compare these drugs on non-psychotic test subjects under suitable conditions. The conditions of the experiment are most important because under certain circumstances the experimental milieu produces so...