Effects of infused tryptamine in man
W. R. Martin, J. W. Sloan
Psychopharmacologia September 1, 1970 DOI: 10.1007/bf00412669 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Human subjects |
| Intervention | Tryptamine |
| Topics | LSD |
| Keywords | Tryptamine Subjective effects Drug-induced psychosis |
| Key findings | Intravenous tryptamine produces physiological and subjective effects similar to LSD-like hallucinogens, consistent with the hypothesis that these hallucinogens interact with tryptamine receptors. |
Abstract
Tryptamine, infused intravenously in man, facilitates the patellar reflex, dilates pupils and elevates blood pressure. It also causes changes in vision and hearing, as well as nausea, vomiting, dizziness, sweating and heaviness of body. These changes are similar to those produced by LSD-like hallucinogens and are consistent with the hypothesis that LSD-like hallucinogens interact with tryptamine receptors as one mode of action.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 5
- Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases Clinical Toxicology 1975
- A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. Journal of Ethnopharmacology March 1, 1985
- Trace Indoleamines in the Central Nervous System Humana Press eBooks 1985
- Relationship of CNS tryptaminergic processes and the action of LSD-like hallucinogens. Pharmacology, Biochemistry, and Behavior February 1986
- Transcallosally evoked potentials and the EEG in the decerebrate dog: actions of tryptaminergic, dopaminergic and adrenergic agonists. Electroencephalography and Clinical Neurophysiology June 1977